عوامل التخثر

من ويكيبيديا، الموسوعة الحرة
اذهب إلى: تصفح، ‏ ابحث


عوامل التخثر هي مواد مطلوبة في عملية تخثر الدم.

عوامل التخثر والمواد المتعلقة
رقم أو اسم عامل التخثر الوضيفة
I (فيبرينوجين) أشكال تجلط (الليفين)
II (بروثرومبين) Its active form (IIa) activates I, V, VII, XIII, protein C, platelets
Tissue factor Co-factor of VIIa (formerly known as factor III)
كالسيوم Required for coagulation factors to bind to phospholipid (formerly known as factor IV)
V (proaccelerin, labile factor) Co-factor of X with which it forms the prothrombinase complex
VI Unassigned – old name of Factor Va
VII (stable factor) Activates IX, X
VIII (antihemophilic factor) Co-factor of IX with which it forms the tenase complex
IX (Christmas factor) Activates X: forms tenase complex with factor VIII
X (Stuart-Prower factor) Activates II: froms prothrombinase complex with factor V
XI (plasma thromboplastin antecedent) Activates XII, IX and prekallikrein
XII (Hageman factor) Activates prekallikrein and fibrinolysis
XIII (fibrin-stabilizing factor) Crosslinks fibrin
عامل فون ويليبراند Binds to VIII, mediates platelet adhesion
prekallikrein Activates XII and prekallikrein; cleaves HMWK
high molecular weight kininogen (HMWK) Supports reciprocal activation of XII, XI, and prekallikrein
فايبرونيكتين Mediates cell adhesion
ضد الثرومبين III Inhibits IIa, Xa, and other proteases;
heparin cofactor II Inhibits IIa, cofactor for heparin and dermatan sulfate ("minor antithrombin")
بروتين C Inactivates Va and VIIIa
بروتين S Cofactor for activated protein C (APC, inactive when bound to C4b-binding protein)
بروتين Z Mediates thrombin adhesion to phospholipids and stimulates degradation of factor X by ZPI
Protein Z-related protease inhibitor (ZPI) Degrades factors X (in presence of protein Z) and XI (independently)
plasminogen Converts to plasmin, lyses fibrin and other proteins
alpha 2-antiplasmin Inhibits plasmin
tissue plasminogen activator (tPA) Activates plasminogen
urokinase Activates plasminogen
plasminogen activator inhibitor-1 (PAI1) Inactivates tPA & urokinase (endothelial PAI)
plasminogen activator inhibitor-2 (PAI2) Inactivates tPA & urokinase (مشيميl PAI)
cancer procoagulant Pathological factor X activator linked to thrombosis in سرطان
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