BPTF
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هذا القسم فارغ أو غير مكتمل، ساهم بتحريره.
هذا القسم فارغ أو غير مكتمل، ساهم بتحريره.
BPTF (Bromodomain PHD finger transcription factor) هوَ بروتين يُشَفر بواسطة جين BPTF في الإنسان.[1][1][2][3][4]
الوظيفة[عدل]

الأهمية السريرية[عدل]

المراجع[عدل]
- ↑ أ ب "Entrez Gene: BPTF bromodomain PHD finger transcription factor". مؤرشف من الأصل في 05 ديسمبر 2010.
- ^ Bowser R (March 1997). "Assignment of the human FAC1 gene to chromosome 17q24 by fluorescence in situ hybridization". Genomics. 38 (3): 455–7. PMID 8975731. doi:10.1006/geno.1996.0657.
- ^ Jones MH، Hamana N، Shimane M (April 2000). "Identification and characterization of BPTF, a novel bromodomain transcription factor". Genomics. 63 (1): 35–9. PMID 10662542. doi:10.1006/geno.1999.6070.
- ^ Wysocka J، Swigut T، Xiao H، Milne TA، Kwon SY، Landry J، Kauer M، Tackett AJ، Chait BT، Badenhorst P، Wu C، Allis CD (July 2006). "A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling". Nature. 442 (7098): 86–90. Bibcode:2006Natur.442...86W. PMID 16728976. doi:10.1038/nature04815.
قراءة متعمقة[عدل]
- Bowser R، Giambrone A، Davies P (1995). "FAC1, a novel gene identified with the monoclonal antibody Alz50, is developmentally regulated in human brain". Dev. Neurosci. 17 (1): 20–37. PMID 7621746. doi:10.1159/000111270.
- Bonaldo MF، Lennon G، Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548. doi:10.1101/gr.6.9.791.
- Zhu P، Bowser R (1997). "Identification and analysis of the complete cDNA sequence for the human FAC1 gene". Biochim. Biophys. Acta. 1309 (1–2): 5–8. PMID 8950167. doi:10.1016/s0167-4781(96)00127-3.
- Mu X، Springer JE، Bowser R (1997). "FAC1 expression and localization in motor neurons of developing, adult, and amyotrophic lateral sclerosis spinal cord". Exp. Neurol. 146 (1): 17–24. PMID 9225734. doi:10.1006/exnr.1997.6508.
- Jordan-Sciutto KL، Dragich JM، Bowser R (1999). "DNA binding activity of the fetal Alz-50 clone 1 (FAC1) protein is enhanced by phosphorylation". Biochem. Biophys. Res. Commun. 260 (3): 785–9. PMID 10403843. doi:10.1006/bbrc.1999.0986.
- Jordan-Sciutto KL، Dragich JM، Rhodes JL، Bowser R (2000). "Fetal Alz-50 clone 1, a novel zinc finger protein, binds a specific DNA sequence and acts as a transcriptional regulator". J. Biol. Chem. 274 (49): 35262–8. PMC 3670955
. PMID 10575013. doi:10.1074/jbc.274.49.35262.
- Jordan-Sciutto KL، Dragich JM، Caltagarone J، وآخرون. (2000). "Fetal Alz-50 clone 1 (FAC1) protein interacts with the Myc-associated zinc finger protein (ZF87/MAZ) and alters its transcriptional activity". Biochemistry. 39 (12): 3206–15. PMC 3667205
. PMID 10727212. doi:10.1021/bi992211q.
- Jordan-Sciutto K، Rhodes J، Bowser R (2002). "Altered subcellular distribution of transcriptional regulators in response to Abeta peptide and during Alzheimer's disease". Mech. Ageing Dev. 123 (1): 11–20. PMID 11640947. doi:10.1016/S0047-6374(01)00334-7.
- Strausberg RL، Feingold EA، Grouse LH، وآخرون. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. PMC 139241
. PMID 12477932. doi:10.1073/pnas.242603899.
- Rhodes J، Lutka FA، Jordan-Sciutto KL، Bowser R (2003). "Altered expression and distribution of FAC1 during NGF-induced neurite outgrowth of PC12 cells". NeuroReport. 14 (3): 449–52. PMID 12634501. doi:10.1097/01.wnr.0000059782.23521.35.
- Barak O، Lazzaro MA، Lane WS، وآخرون. (2004). "Isolation of human NURF: a regulator of Engrailed gene expression". EMBO J. 22 (22): 6089–100. PMC 275440
. PMID 14609955. doi:10.1093/emboj/cdg582.
- Ota T، Suzuki Y، Nishikawa T، وآخرون. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
- Beausoleil SA، Jedrychowski M، Schwartz D، وآخرون. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. PMC 514446
. PMID 15302935. doi:10.1073/pnas.0404720101.
- Strachan GD، Morgan KL، Otis LL، وآخرون. (2004). "Fetal Alz-50 clone 1 interacts with the human orthologue of the Kelch-like Ech-associated protein". Biochemistry. 43 (38): 12113–22. PMID 15379550. doi:10.1021/bi0494166.
- Gerhard DS، Wagner L، Feingold EA، وآخرون. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. PMC 528928
. PMID 15489334. doi:10.1101/gr.2596504.
- Strachan GD، Ostrow LA، Jordan-Sciutto KL (2005). "Expression of the fetal Alz-50 clone 1 protein induces apoptotic cell death". Biochem. Biophys. Res. Commun. 336 (2): 490–5. PMID 16137655. doi:10.1016/j.bbrc.2005.08.127.
- Li H، Ilin S، Wang W، وآخرون. (2006). "Molecular basis for site-specific read-out of histone H3K4me3 by the BPTF PHD finger of NURF". Nature. 442 (7098): 91–5. Bibcode:2006Natur.442...91L. PMID 16728978. doi:10.1038/nature04802.
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