CDC73

CDC73
المعرفات
الأسماء المستعارة	CDC73, C1orf28, FIHP, HPTJT, HRPT1, HRPT2, HYX, cell division cycle 73
معرفات خارجية	الوراثة المندلية البشرية عبر الإنترنت 607393 MGI: MGI:2384876 HomoloGene: 11571 GeneCards: 79577
علم الوجود الجيني الوظيفة الجزيئية • RNA polymerase II complex binding • ‏GO:0001948 ربط بروتيني المكونات الخلوية • بلازم نووي • Cdc73/Paf1 complex • نواة • عصارة خلوية العمليات الحيوية • histone monoubiquitination • ضبط نسخ الدنا • positive regulation of mRNA 3'-end processing • histone modification • negative regulation of transcription by RNA polymerase II • بروتين دبيلو.أن.تي • نسخ الدنا • stem cell population maintenance • negative regulation of G1/S transition of mitotic cell cycle • positive regulation of Wnt signaling pathway • mRNA polyadenylation • endodermal cell fate commitment • protein destabilization • negative regulation of epithelial cell proliferation • دورة الخلية • histone H2B ubiquitination • cellular response to lipopolysaccharide • negative regulation of myeloid cell differentiation • negative regulation of fibroblast proliferation • positive regulation of transcription elongation from RNA polymerase II promoter • negative regulation of cell population proliferation • ضبط زيادي للنسخ انطلاقا من محفز بوليميراز الرنا الثاني • beta-catenin-TCF complex assembly • regulation of cell growth • ضبط النسخ انطلاقاً من محفز بوليميراز الرنا الثاني • transcription by RNA polymerase II • transcription elongation from RNA polymerase II promoter • protein ubiquitination • recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex • negative regulation of apoptotic process • positive regulation of cell cycle G1/S phase transition المصادر:Amigo / QuickGO
أورثولوج
الأنواع	الإنسان	الفأر
أنتريه	79577	214498
Ensembl	ENSG00000134371	ENSMUSG00000026361
يونيبروت	Q6P1J9	Q8JZM7
RefSeq (مرسال ر.ن.ا.)	‏NM_024529 XM_006711537، ‏NM_024529	‏XM_006529365، ‏XM_006529366 NM_145991، ‏XM_006529365، ‏XM_006529366
RefSeq (بروتين)	‏XP_006711600 NP_078805، ‏XP_006711600	‏XP_006529428، ‏XP_006529429 NP_666103، ‏XP_006529428، ‏XP_006529429
الموقع (UCSC	n/a	Chr 1: 143.6 – 143.7 Mb
بحث ببمد	[1]	[2]
ويكي بيانات
اعرض/عدّل إنسان اعرض/عدّل فأر

CDC73‏ (Cell division cycle 73) هوَ بروتين يُشَفر بواسطة جين CDC73 في الإنسان.

الوظيفة

هذا القسم فارغ أو غير مكتمل، ساهم بتحريره.

الأهمية السريرية

هذا القسم فارغ أو غير مكتمل، ساهم بتحريره.

قراءة متعمقة

• "Hereditary hyperparathyroidism-jaw tumor syndrome: the endocrine tumor gene HRPT2 maps to chromosome 1q21-q31". Am. J. Hum. Genet. 56 (4): 944–50. 1995. PMC 1801214. PMID 7717405.
• "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• "Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus". Genomics. 73 (2): 211–22. 2001. doi:10.1006/geno.2001.6500. PMID 11318611.
• "Revised 14.7-cM locus for the hyperparathyroidism-jaw tumor syndrome gene, HRPT2". Am. J. Hum. Genet. 70 (5): 1376–7. 2002. doi:10.1086/340093. PMC 447614. PMID 11951180.
• "HRPT2, encoding parafibromin, is mutated in hyperparathyroidism-jaw tumor syndrome". Nat. Genet. 32 (4): 676–80. 2003. doi:10.1038/ng1048. PMID 12434154.
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• "HRPT2 mutations are associated with malignancy in sporadic parathyroid tumours". J. Med. Genet. 40 (9): 657–63. 2003. doi:10.1136/jmg.40.9.657. PMC 1735580. PMID 12960210.
• "Somatic and germ-line mutations of the HRPT2 gene in sporadic parathyroid carcinoma". N. Engl. J. Med. 349 (18): 1722–9. 2003. doi:10.1056/NEJMoa031237. PMID 14585940.
• "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
• "Familial isolated hyperparathyroidism is rarely caused by germline mutation in HRPT2, the gene for the hyperparathyroidism-jaw tumor syndrome". J. Clin. Endocrinol. Metab. 89 (1): 96–102. 2004. doi:10.1210/jc.2003-030675. PMID 14715834.
• "Genetic testing in familial isolated hyperparathyroidism: unexpected results and their implications". J. Med. Genet. 41 (3): 155–60. 2004. doi:10.1136/jmg.2003.016725. PMC 1735699. PMID 14985373.
• "Germline and de novo mutations in the HRPT2 tumour suppressor gene in familial isolated hyperparathyroidism (FIHP)". J. Med. Genet. 41 (3): e32. 2004. doi:10.1136/jmg.2003.012369. PMC 1735713. PMID 14985403.
• "Human gene mutations. Gene symbol: HRPT2. Disease: Hyperparathyroidism Jaw-tumor syndrome". Hum. Genet. 114 (2): 221. 2004. doi:10.1007/s00439-003-1060-z. PMID 15046050.
• "Human gene mutations. Gene symbol: HRPT2. Disease: Hyperparathyroidism Jaw-tumor syndrome". Hum. Genet. 114 (2): 222. 2004. doi:10.1007/s00439-003-1060-z. PMID 15046094.
• "Human gene mutations. Gene symbol: HRPT2. Disease: Hyperparathyroidism Jaw-tumor syndrome". Hum. Genet. 114 (2): 222. 2004. doi:10.1007/s00439-003-1060-z. PMID 15046098.
• "Human gene mutations. Gene symbol: HRPT2. Disease: Hyperparathyroidism Jaw-tumor syndrome". Hum. Genet. 114 (2): 223. 2004. doi:10.1007/s00439-003-1060-z. PMID 15046102.
• "Human gene mutations. Gene symbol: HRPT2. Disease: Hyperparathyroidism Jaw-tumor syndrome". Hum. Genet. 114 (2): 223. 2004. doi:10.1007/s00439-003-1060-z. PMID 15046105.
• "Human gene mutations. Gene symbol: HRPT2. Disease: Hyperparathyroidism Jaw-tumor syndrome". Hum. Genet. 114 (2): 223. 2004. doi:10.1007/s00439-003-1060-z. PMID 15046107.
• "Human gene mutations. Gene symbol: HRPT2. Disease: Hyperparathyroidism Jaw-tumor syndrome". Hum. Genet. 114 (2): 224. 2004. doi:10.1007/s00439-003-1060-z. PMID 15046109.

هذه بذرة مقالة عن جين على كروموسوم 1 بحاجة للتوسيع. شارك في تحريرها.