Elafin

من ويكيبيديا، الموسوعة الحرة
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Peptidase inhibitor 3
المعرفات
الأسماء المستعارة peptidase inhibitor 3, skin-derived, protease inhibitor WAP3, skin-derived antileukoproteinase, PI-3, WAP four-disulfide core domain 14, trappin-2, elafin, ESI, pre-elafin, protease inhibitor 3, skin-derived (SKALP), elastase-specific inhibitor, PI3, SKALP, WAP four-disulfide core domain protein 14
معرفات خارجية
نمط التعبير عن الحمض النووي الريبوزي
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المزيد من بيانات التعبير المرجعية
أورثولوج
الأنواع الإنسان الفأر
أنتريه n/a
Ensembl n/a n/a
يونيبروت
RefSeq (مرسال ر.ن.ا.)

n/a

n/a

RefSeq (بروتين)

n/a

n/a

الموقع (UCSC n/a
بحث ببمد n/a
ويكي بيانات
اعرض/عدّل إنسان

Elafin‏ (None) هوَ بروتين يُشَفر بواسطة جين Elafin في الإنسان.[1][2][3]

الوظيفة[عدل]

الأهمية السريرية[عدل]

المراجع[عدل]

  1. ^ "Entrez Gene: PI3 peptidase inhibitor 3, skin-derived (SKALP)". 
  2. ^ Molhuizen HO، Zeeuwen PL، Olde Weghuis D، Geurts van Kessel A، Schalkwijk J (Feb 1994). "Assignment of the human gene encoding the epidermal serine proteinase inhibitor SKALP (PI3) to chromosome region 20q12→q13". Cytogenet Cell Genet. 66 (2): 129–31. PMID 8287685. doi:10.1159/000133683. 
  3. ^ Clauss A، Lilja H، Lundwall A (Nov 2002). "A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein". Biochem J. 368 (Pt 1): 233–42. PMC 1222987Freely accessible. PMID 12206714. doi:10.1042/BJ20020869. 

قراءة متعمقة[عدل]

  • Sallenave JM (2003). "The role of secretory leukocyte proteinase inhibitor and elafin (elastase-specific inhibitor/skin-derived antileukoprotease) as alarm antiproteinases in inflammatory lung disease.". Respir. Res. 1 (2): 87–92. PMC 59548Freely accessible. PMID 11667971. doi:10.1186/rr18. 
  • Saheki T، Ito F، Hagiwara H، وآخرون. (1992). "Primary structure of the human elafin precursor preproelafin deduced from the nucleotide sequence of its gene and the presence of unique repetitive sequences in the prosegment.". Biochem. Biophys. Res. Commun. 185 (1): 240–5. PMID 1339270. doi:10.1016/S0006-291X(05)80981-7. 
  • Sallenave JM، Marsden MD، Ryle AP (1992). "Isolation of elafin and elastase-specific inhibitor (ESI) from bronchial secretions. Evidence of sequence homology and immunological cross-reactivity.". Biol. Chem. Hoppe-Seyler. 373 (1): 27–33. PMID 1536690. doi:10.1515/bchm3.1992.373.1.27. 
  • Chang A، Schalkwijk J، Happle R، van de Kerkhof PC (1990). "Elastase-inhibiting activity in scaling skin disorders.". Acta Derm. Venereol. 70 (2): 147–51. PMID 1969201. 
  • Schalkwijk J، de Roo C، de Jongh GJ (1991). "Skin-derived antileukoproteinase (SKALP), an elastase inhibitor from human keratinocytes. Purification and biochemical properties.". Biochim. Biophys. Acta. 1096 (2): 148–54. PMID 2001428. doi:10.1016/0925-4439(91)90053-c. 
  • Sallenave JM، Ryle AP (1991). "Purification and characterization of elastase-specific inhibitor. Sequence homology with mucus proteinase inhibitor.". Biol. Chem. Hoppe-Seyler. 372 (1): 13–21. PMID 2039600. doi:10.1515/bchm3.1991.372.1.13. 
  • Wiedow O، Schröder JM، Gregory H، وآخرون. (1990). "Elafin: an elastase-specific inhibitor of human skin. Purification, characterization, and complete amino acid sequence.". J. Biol. Chem. 265 (25): 14791–5. PMID 2394696. 
  • Molhuizen HO، Alkemade HA، Zeeuwen PL، وآخرون. (1993). "SKALP/elafin: an elastase inhibitor from cultured human keratinocytes. Purification, cDNA sequence, and evidence for transglutaminase cross-linking.". J. Biol. Chem. 268 (16): 12028–32. PMID 7685029. 
  • Zhang M، Zou Z، Maass N، Sager R (1995). "Differential expression of elafin in human normal mammary epithelial cells and carcinomas is regulated at the transcriptional level.". Cancer Res. 55 (12): 2537–41. PMID 7780965. 
  • Sallenave JM، Silva A (1993). "Characterization and gene sequence of the precursor of elafin, an elastase-specific inhibitor in bronchial secretions.". Am. J. Respir. Cell Mol. Biol. 8 (4): 439–45. PMID 8476637. doi:10.1165/ajrcmb/8.4.439. 
  • Tsunemi M، Matsuura Y، Sakakibara S، Katsube Y (1996). "Crystal structure of an elastase-specific inhibitor elafin complexed with porcine pancreatic elastase determined at 1.9 A resolution.". Biochemistry. 35 (36): 11570–6. PMID 8794736. doi:10.1021/bi960900l. 
  • Pfundt R، van Ruissen F، van Vlijmen-Willems IM، وآخرون. (1996). "Constitutive and inducible expression of SKALP/elafin provides anti-elastase defense in human epithelia.". J. Clin. Invest. 98 (6): 1389–99. PMC 507565Freely accessible. PMID 8823304. doi:10.1172/JCI118926. 
  • Steinert PM، Marekov LN (1997). "Direct evidence that involucrin is a major early isopeptide cross-linked component of the keratinocyte cornified cell envelope.". J. Biol. Chem. 272 (3): 2021–30. PMID 8999895. doi:10.1074/jbc.272.3.2021. 
  • Francart C، Dauchez M، Alix AJ، Lippens G (1997). "Solution structure of R-elafin, a specific inhibitor of elastase.". J. Mol. Biol. 268 (3): 666–77. PMID 9171290. doi:10.1006/jmbi.1997.0983. 
  • Kuijpers AL، Pfundt R، Zeeuwen PL، وآخرون. (1998). "SKALP/elafin gene polymorphisms are not associated with pustular forms of psoriasis.". Clin. Genet. 54 (1): 96–101. PMID 9727750. doi:10.1111/j.1399-0004.1998.tb03703.x. 
  • Mihaila A، Tremblay GM (2001). "Human alveolar macrophages express elafin and secretory leukocyte protease inhibitor.". Z. Naturforsch. C. 56 (3-4): 291–7. PMID 11371023. 
  • Simpson AJ، Wallace WA، Marsden ME، وآخرون. (2001). "Adenoviral augmentation of elafin protects the lung against acute injury mediated by activated neutrophils and bacterial infection.". J. Immunol. 167 (3): 1778–86. PMID 11466403. doi:10.4049/jimmunol.167.3.1778. 
  • Sumi Y، Inoue N، Azumi H، وآخرون. (2002). "Expression of tissue transglutaminase and elafin in human coronary artery: implication for plaque instability.". Atherosclerosis. 160 (1): 31–9. PMID 11755920. doi:10.1016/S0021-9150(01)00542-1. 
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