POU2AF1
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هذا القسم فارغ أو غير مكتمل، ساهم بتحريره.
هذا القسم فارغ أو غير مكتمل، ساهم بتحريره.
POU2AF1 (POU class 2 associating factor 1) هوَ بروتين يُشَفر بواسطة جين POU2AF1 في الإنسان.[1][2]
الوظيفة[عدل]
هذا القسم فارغ أو غير مكتمل، ساهم بتحريره.الأهمية السريرية[عدل]
هذا القسم فارغ أو غير مكتمل، ساهم بتحريره.المراجع[عدل]
- ^ "Entrez Gene: POU2AF1 POU domain, class 2, associating factor 1".
- ^ Junker S، Brøndum-Nielsen K، Newell JW، Matthias P، Tommerup N (Jun 1996). "Assignment of the human gene for Oct-binding factor-1 (OBF1), a B-cell-specific coactivator of octamer-binding transcription factors 1 and 2, to 11q23.1 by somatic cell hybridization and in situ hybridization". Genomics. 33 (1): 143–5. PMID 8617501. doi:10.1006/geno.1996.0173.
قراءة متعمقة[عدل]
- Teitell MA (2004). "OCA-B regulation of B-cell development and function". Trends Immunol. 24 (10): 546–53. PMID 14552839. doi:10.1016/j.it.2003.08.002.
- Luo Y، Roeder RG (1995). "Cloning, functional characterization, and mechanism of action of the B-cell-specific transcriptional coactivator OCA-B". Mol. Cell. Biol. 15 (8): 4115–24. PMC 230650
. PMID 7623806. - Gstaiger M، Knoepfel L، Georgiev O، Schaffner W، Hovens CM (1995). "A B-cell coactivator of octamer-binding transcription factors". Nature. 373 (6512): 360–2. PMID 7779176. doi:10.1038/373360a0.
- Strubin M، Newell JW، Matthias P (1995). "OBF-1, a novel B cell-specific coactivator that stimulates immunoglobulin promoter activity through association with octamer-binding proteins". Cell. 80 (3): 497–506. PMID 7859290. doi:10.1016/0092-8674(95)90500-6.
- Galiègue-Zouitina S، Quief S، Hildebrand MP، Denis C، Lecocq G، Collyn-d'Hooghe M، Bastard C، Yuille M، Dyer MJ، Kerckaert JP (1996). "Fusion of the LAZ3/BCL6 and BOB1/OBF1 genes by t(3; 11) (q27; q23) chromosomal translocation". Comptes Rendus de l'Académie des Sciences, Série III. 318 (11): 1125–31. PMID 8574789.
- Zwilling S، Dieckmann A، Pfisterer P، Angel P، Wirth T (1997). "Inducible expression and phosphorylation of coactivator BOB.1/OBF.1 in T cells". Science. 277 (5323): 221–5. PMID 9211847. doi:10.1126/science.277.5323.221.
- Sauter P، Matthias P (1998). "The B cell-specific coactivator OBF-1 (OCA-B, Bob-1) is inducible in T cells and its expression is dispensable for IL-2 gene induction". Immunobiology. 198 (1–3): 207–16. PMID 9442392. doi:10.1016/S0171-2985(97)80041-1.
- Luo Y، Ge H، Stevens S، Xiao H، Roeder RG (1998). "Coactivation by OCA-B: Definition of Critical Regions and Synergism with General Cofactors". Mol. Cell. Biol. 18 (7): 3803–10. PMC 108964. PMID 9632764. doi:10.1128/mcb.18.7.3803.
- Sauter P، Matthias P (1998). "Coactivator OBF-1 Makes Selective Contacts with Both the POU-Specific Domain and the POU Homeodomain and Acts as a Molecular Clamp on DNA". Mol. Cell. Biol. 18 (12): 7397–409. PMC 109321. PMID 9819426.
- Chasman D، Cepek K، Sharp PA، Pabo CO (1999). "Crystal structure of an OCA-B peptide bound to an Oct-1 POU domain/octamer DNA complex: specific recognition of a protein-DNA interface". Genes Dev. 13 (20): 2650–7. PMC 317104. PMID 10541551. doi:10.1101/gad.13.20.2650.
- Tomilin A، Reményi A، Lins K، Bak H، Leidel S، Vriend G، Wilmanns M، Schöler HR (2001). "Synergism with the coactivator OBF-1 (OCA-B, BOB-1) is mediated by a specific POU dimer configuration". Cell. 103 (6): 853–64. PMID 11136971. doi:10.1016/S0092-8674(00)00189-6.
- Lee L، Stollar E، Chang J، Grossmann JG، O'Brien R، Ladbury J، Carpenter B، Roberts S، Luisi B (2001). "Expression of the Oct-1 transcription factor and characterization of its interactions with the Bob1 coactivator". Biochemistry. 40 (22): 6580–8. PMID 11380252. doi:10.1021/bi010095x.
- Tiedt R، Bartholdy BA، Matthias G، Newell JW، Matthias P (2001). "The RING finger protein Siah-1 regulates the level of the transcriptional coactivator OBF-1". EMBO J. 20 (15): 4143–52. PMC 149178. PMID 11483517. doi:10.1093/emboj/20.15.4143.
- Boehm J، He Y، Greiner A، Staudt L، Wirth T (2001). "Regulation of BOB.1/OBF.1 stability by SIAH". EMBO J. 20 (15): 4153–62. PMC 149152. PMID 11483518. doi:10.1093/emboj/20.15.4153.
- Malone CS، Wall R (2002). "Bob1 (OCA-B/OBF-1) differential transactivation of the B cell-specific B29 (Ig beta) and mb-1 (Ig alpha) promoters". J. Immunol. 168 (7): 3369–75. PMID 11907094. doi:10.4049/jimmunol.168.7.3369.
- Casellas R، Jankovic M، Meyer G، Gazumyan A، Luo Y، Roeder R، Nussenzweig M (2003). "OcaB is required for normal transcription and V(D)J recombination of a subset of immunoglobulin kappa genes". Cell. 110 (5): 575–85. PMID 12230975. doi:10.1016/S0092-8674(02)00911-X.
- Schaffer A، Kim EC، Wu X، Zan H، Testoni L، Salamon S، Cerutti A، Casali P (2003). "Selective inhibition of class switching to IgG and IgE by recruitment of the HoxC4 and Oct-1 homeodomain proteins and Ku70/Ku86 to newly identified ATTT cis-elements". J. Biol. Chem. 278 (25): 23141–50. PMID 12672812. doi:10.1074/jbc.M212952200.
- Lins K، Reményi A، Tomilin A، Massa S، Wilmanns M، Matthias P، Schöler HR (2003). "OBF1 enhances transcriptional potential of Oct1". EMBO J. 22 (9): 2188–98. PMC 156071. PMID 12727885. doi:10.1093/emboj/cdg199.
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