SFRS4

SRSF4
المعرفات
الأسماء المستعارة	SRSF4, SFRS4, SRP75, serine/arginine-rich splicing factor 4, serine and arginine rich splicing factor 4
معرفات خارجية	الوراثة المندلية البشرية عبر الإنترنت 601940 MGI: MGI:1890577 HomoloGene: 25624 GeneCards: 6429
علم الوجود الجيني الوظيفة الجزيئية • sequence-specific mRNA binding • ربط حمض نووي • ‏GO:0001948 ربط بروتيني • RNA binding • nucleotide binding المكونات الخلوية • نواة • بلازم نووي • nuclear speck العمليات الحيوية • RNA splicing, via transesterification reactions • mRNA splicing, via spliceosome • termination of RNA polymerase II transcription • mRNA processing • negative regulation of mRNA splicing, via spliceosome • mRNA 3'-end processing • mRNA export from nucleus • تضفير الآر أن إيه • RNA export from nucleus • response to insulin • regulation of alternative mRNA splicing, via spliceosome • mRNA cis splicing, via spliceosome المصادر:Amigo / QuickGO
نمط التعبير عن الحمض النووي الريبوزي
المزيد من بيانات التعبير المرجعية
أورثولوج
الأنواع	الإنسان	الفأر
أنتريه	6429	57317
Ensembl	ENSG00000116350	ENSMUSG00000028911
يونيبروت	Q08170 A0A0D9SGD2	Q8VE97
RefSeq (مرسال ر.ن.ا.)	‏NM_005626 XM_011541951، ‏NM_005626	‏XM_017320333، ‏XM_017320334، ‏XM_017320335 NM_020587، ‏XM_017320333، ‏XM_017320334، ‏XM_017320335
RefSeq (بروتين)	‏XP_011540253 NP_005617، ‏XP_011540253	n/a
الموقع (UCSC	n/a	Chr 4: 131.87 – 131.9 Mb
بحث ببمد	[1]	[2]
ويكي بيانات
اعرض/عدّل إنسان اعرض/عدّل فأر

SFRS4‏ (Serine/arginine-rich-splicing factor 4) هوَ بروتين يُشَفر بواسطة جين SFRS4 في الإنسان.

الوظيفة

هذا القسم فارغ أو غير مكتمل، ساهم بتحريره.

الأهمية السريرية

هذا القسم فارغ أو غير مكتمل، ساهم بتحريره.

قراءة متعمقة

• Zahler AM; Lane WS; Stolk JA; Roth MB (1992). "SR proteins: a conserved family of pre-mRNA splicing factors". Genes Dev. 6 (5): 837–47. doi:10.1101/gad.6.5.837. PMID 1577277.
• "A subset of SR proteins activates splicing of the cardiac troponin T alternative exon by direct interactions with an exonic enhancer". Mol. Cell. Biol. 15 (9): 4898–907. 1995. PMC 230736. PMID 7651409.
• Maruyama K; Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Gui JF; Lane WS; Fu XD (1994). "A serine kinase regulates intracellular localization of splicing factors in the cell cycle". Nature. 369 (6482): 678–82. Bibcode:1994Natur.369..678G. doi:10.1038/369678a0. PMID 8208298.
• "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Zhang WJ; Wu JY (1998). "Sip1, a Novel RS Domain-Containing Protein Essential for Pre-mRNA Splicing". Mol. Cell. Biol. 18 (2): 676–84. PMC 108778. PMID 9447963.
• Blencowe BJ; Issner R; Nickerson JA; Sharp PA (1998). "A coactivator of pre-mRNA splicing". Genes Dev. 12 (7): 996–1009. doi:10.1101/gad.12.7.996. PMC 316672. PMID 9531537.
• "SR protein-specific kinase 1 is highly expressed in testis and phosphorylates protamine 1". Nucleic Acids Res. 27 (14): 2972–80. 1999. doi:10.1093/nar/27.14.2972. PMC 148514. PMID 10390541.
• "Direct coupling of transcription and mRNA processing through the thermogenic coactivator PGC-1". Mol. Cell. 6 (2): 307–16. 2000. doi:10.1016/S1097-2765(00)00031-9. PMID 10983978.
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• "Proto-oncoprotein TLS/FUS is associated to the nuclear matrix and complexed with splicing factors PTB, SRm160, and SR proteins". Exp. Cell Res. 283 (2): 184–95. 2003. doi:10.1016/S0014-4827(02)00046-0. PMID 12581738.
• "Regulation of Alternative Splicing by SRrp86 and Its Interacting Proteins". Mol. Cell. Biol. 23 (21): 7437–47. 2003. doi:10.1128/MCB.23.21.7437-7447.2003. PMC 207616. PMID 14559993.
• "Pinin/DRS/memA interacts with SRp75, SRm300 and SRrp130 in corneal epithelial cells". Invest. Ophthalmol. Vis. Sci. 44 (11): 4715–23. 2003. doi:10.1167/iovs.03-0240. PMID 14578391.
• "Characterization of cyclin L2, a novel cyclin with an arginine/serine-rich domain: phosphorylation by DYRK1A and colocalization with splicing factors". J. Biol. Chem. 279 (6): 4612–24. 2004. doi:10.1074/jbc.M310794200. PMID 14623875.
• "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. 2005. doi:10.1038/nbt1046. PMID 15592455.
• "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. 2005. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153.
• "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. 2005. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.
• "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. 2006. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.

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