عوامل التخثر

عوامل التخثر هي مواد مطلوبة في عملية تخثر الدم.

عوامل التخثر والمواد المتعلقة

رقم أو اسم عامل التخثر	الوضيفة
I (فيبرينوجين)	أشكال تجلط (الليفين)
II (بروثرومبين)	Its active form (IIa) activates I, V, VII, XIII, protein C, platelets
ثرومبوبلاستين	Co-factor of VIIa (formerly known as factor III)
كالسيوم	Required for coagulation factors to bind to phospholipid (formerly known as factor IV)
V (proaccelerin, labile factor)	Co-factor of X with which it forms the prothrombinase complex
VI	Unassigned – old name of Factor Va
VII (stable factor)	Activates IX, X
VIII (antihemophilic factor)	Co-factor of IX with which it forms the tenase complex
IX (Christmas factor)	Activates X: forms tenase complex with factor VIII
X (Stuart-Prower factor)	Activates II: froms prothrombinase complex with factor V
XI (plasma thromboplastin antecedent)	Activates XII, IX and prekallikrein
XII (Hageman factor)	Activates prekallikrein and انحلال الفبرين
XIII (fibrin-stabilizing factor)	Crosslinks fibrin
عامل فون ويليبراند	Binds to VIII, mediates platelet adhesion
prekallikrein	Activates XII and prekallikrein; cleaves HMWK
high molecular weight kininogen (HMWK)	Supports reciprocal activation of XII, XI, and prekallikrein
فايبرونيكتين	Mediates cell adhesion
ضد الثرومبين III	Inhibits IIa, Xa, and other proteases;
heparin cofactor II	Inhibits IIa, cofactor for heparin and dermatan sulfate ("minor antithrombin")
بروتين C	Inactivates Va and VIIIa
بروتين S	Cofactor for activated protein C (APC, inactive when bound to C4b-binding protein)
بروتين Z	Mediates thrombin adhesion to phospholipids and stimulates degradation of factor X by ZPI
Protein Z-related protease inhibitor (ZPI)	Degrades factors X (in presence of protein Z) and XI (independently)
بلازمين	Converts to plasmin, lyses fibrin and other proteins
alpha 2-antiplasmin	Inhibits plasmin
منشط بلازمينوجين النسيجي (tPA)	Activates plasminogen
يوروكيناز	Activates plasminogen
plasminogen activator inhibitor-1 (PAI1)	Inactivates tPA & urokinase (endothelial PAI)
plasminogen activator inhibitor-2 (PAI2)	Inactivates tPA & urokinase (مشيميl PAI)
cancer procoagulant	Pathological العامل العاشر activator linked to thrombosis in سرطان