The last four stages of the tournament (round of 16, quarterfinals, semifinals, and finals) form a خروج المغلوب، commonly known as a knockout stage. Fourteen teams will qualify for the knockout competition: the eight group winners, the six group runners-up teams with the best records plus Mexican clubs Guadalajara and San Luis.[2]
The 16 qualified teams were seeded according to their results in the Second Stage. The top teams from each group were seeded 1-8, with the team with the most points as seed 1 and the team with the least as seed 8. The second-best teams from each group were seeded 9-16, with the team with the most points as seed 9 and the team with the least as seed 16. Guadalajara and San Luis were given the 13 and 14 seed, respectively, which they had earned in the كأس ليبرتادوريس 2009.
Because of the participation of 5 Mexican teams this edition, should 3 or more Mexican teams reach the quarterfinals, they will be forced to face each other to prevent a single-country final. The lowest seeded team will face the highest seeded team.[3]
Should 3 or more teams from a same country reach the semifinals, they will be forced to face each other. The lowest seeded team will face the highest seeded team.[3]