LDB1
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هذا القسم فارغ أو غير مكتمل، ساهم بتحريره.
هذا القسم فارغ أو غير مكتمل، ساهم بتحريره.
LDB1 (LIM domain binding 1) هوَ بروتين يُشَفر بواسطة جين LDB1 في الإنسان.[1][2][3]
الوظيفة[عدل]

الأهمية السريرية[عدل]

المراجع[عدل]
- ^ Yamashita T، Agulnick AD، Copeland NG، Gilbert DJ، Jenkins NA، Westphal H (Apr 1998). "Genomic structure and chromosomal localization of the mouse LIM domain-binding protein 1 gene, Ldb1". Genomics. 48 (1): 87–92. PMID 9503020. doi:10.1006/geno.1997.5163.
- ^ "Entrez Gene: LDB1 LIM domain binding 1". مؤرشف من الأصل في 05 ديسمبر 2010.
- ^ Semina EV، Altherr MR، Murray JC (Dec 1998). "Cloning and chromosomal localization of two novel human genes encoding LIM-domain binding factors CLIM1 and CLIM2/LDB1/NLI". Mamm Genome. 9 (11): 921–4. PMID 9799849. doi:10.1007/s003359900899.
قراءة متعمقة[عدل]
- Osada H، Grutz GG، Axelson H، وآخرون. (1997). "LIM-only protein Lmo2 forms a protein complex with erythroid transcription factor GATA-1.". Leukemia. 11 Suppl 3: 307–12. PMID 9209374.
- Wadman IA، Osada H، Grütz GG، وآخرون. (1997). "The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins.". EMBO J. 16 (11): 3145–57. PMC 1169933
. PMID 9214632. doi:10.1093/emboj/16.11.3145.
- Jurata LW، Gill GN (1997). "Functional analysis of the nuclear LIM domain interactor NLI.". Mol. Cell. Biol. 17 (10): 5688–98. PMC 232417
. PMID 9315627.
- Visvader JE، Mao X، Fujiwara Y، وآخرون. (1998). "The LIM-domain binding protein Ldb1 and its partner LMO2 act as negative regulators of erythroid differentiation.". Proc. Natl. Acad. Sci. U.S.A. 94 (25): 13707–12. Bibcode:1997PNAS...9413707V. PMC 28370
. PMID 9391090. doi:10.1073/pnas.94.25.13707.
- Jurata LW، Pfaff SL، Gill GN (1998). "The nuclear LIM domain interactor NLI mediates homo- and heterodimerization of LIM domain transcription factors.". J. Biol. Chem. 273 (6): 3152–7. PMID 9452425. doi:10.1074/jbc.273.6.3152.
- Kenny DA، Jurata LW، Saga Y، Gill GN (1998). "Identification and characterization of LMO4, an LMO gene with a novel pattern of expression during embryogenesis.". Proc. Natl. Acad. Sci. U.S.A. 95 (19): 11257–62. Bibcode:1998PNAS...9511257K. PMC 21629
. PMID 9736723. doi:10.1073/pnas.95.19.11257.
- Valge-Archer V، Forster A، Rabbitts TH (1999). "The LMO1 and LDB1 proteins interact in human T cell acute leukaemia with the chromosomal translocation t(11;14)(p15;q11).". Oncogene. 17 (24): 3199–202. PMID 9872335. doi:10.1038/sj.onc.1202353.
- Ueki N، Seki N، Yano K، وآخرون. (1999). "Isolation and chromosomal assignment of human genes encoding cofactor of LIM homeodomain proteins, CLIM1 and CLIM2.". J. Hum. Genet. 44 (2): 112–5. PMID 10083735. doi:10.1007/s100380050120.
- Drechsler M، Schumacher V، Friedrich S، وآخرون. (2000). "Genomic structure, alternative transcripts and chromosome location of the human LIM domain binding protein 1 gene LDB1.". Cytogenet. Cell Genet. 87 (1–2): 119–24. PMID 10640831. doi:10.1159/000015377.
- Dreyer SD، Morello R، German MS، وآخرون. (2000). "LMX1B transactivation and expression in nail-patella syndrome". Hum. Mol. Genet. 9 (7): 1067–74. PMID 10767331. doi:10.1093/hmg/9.7.1067.
- Sum EY، Peng B، Yu X، وآخرون. (2002). "The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity". J. Biol. Chem. 277 (10): 7849–56. PMID 11751867. doi:10.1074/jbc.M110603200.
- Ostendorff HP، Peirano RI، Peters MA، وآخرون. (2002). "Ubiquitination-dependent cofactor exchange on LIM homeodomain transcription factors". Nature. 416 (6876): 99–103. Bibcode:2002Natur.416...99O. PMID 11882901. doi:10.1038/416099a.
- Deane JE، Visvader JE، Mackay JP، Matthew JM (2003). "1H, 15N and 13C assignments of FLIN4, an intramolecular LMO4:ldb1 complex". J. Biomol. NMR. 23 (2): 165–6. PMID 12153047. doi:10.1023/A:1016363414644.
- Chen L، Segal D، Hukriede NA، وآخرون. (2002). "Ssdp proteins interact with the LIM-domain-binding protein Ldb1 to regulate development". Proc. Natl. Acad. Sci. U.S.A. 99 (22): 14320–5. Bibcode:2002PNAS...9914320C. PMC 137882
. PMID 12381786. doi:10.1073/pnas.212532399.
- Strausberg RL، Feingold EA، Grouse LH، وآخرون. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. PMC 139241
. PMID 12477932. doi:10.1073/pnas.242603899.
- van Meyel DJ، Thomas JB، Agulnick AD (2003). "Ssdp proteins bind to LIM-interacting co-factors and regulate the activity of LIM-homeodomain protein complexes in vivo". Development. 130 (9): 1915–25. PMID 12642495. doi:10.1242/dev.00389.
- Deane JE، Mackay JP، Kwan AH، وآخرون. (2003). "Structural basis for the recognition of ldb1 by the N-terminal LIM domains of LMO2 and LMO4". EMBO J. 22 (9): 2224–33. PMC 156068
. PMID 12727888. doi:10.1093/emboj/cdg196.
- Marini M، Bongers EM، Cusano R، وآخرون. (2004). "Confirmation of CLIM2/LMX1B interaction by yeast two-hybrid screening and analysis of its involvement in nail-patella syndrome". Int. J. Mol. Med. 12 (1): 79–82. PMID 12792813. doi:10.3892/ijmm.12.1.79.
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