GDF6
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هذا القسم فارغ أو غير مكتمل، ساهم بتحريره.
هذا القسم فارغ أو غير مكتمل، ساهم بتحريره.
GDF6 (Growth differentiation factor 6) هوَ بروتين يُشَفر بواسطة جين GDF6 في الإنسان.[1]
الوظيفة[عدل]

الأهمية السريرية[عدل]

المراجع[عدل]
- ^ Davidson AJ، Postlethwait JH، Yan YL، Beier DR، van Doren C، Foernzler D، Celeste AJ، Crosier KE، Crosier PS (February 1999). "Isolation of zebrafish gdf7 and comparative genetic mapping of genes belonging to the growth/differentiation factor 5, 6, 7 subgroup of the TGF-beta superfamily". Genome Res. 9 (2): 121–9. PMID 10022976. doi:10.1101/gr.9.2.121.
قراءة متعمقة[عدل]
- Chiquet BT، Hashmi SS، Henry R، وآخرون. (2009). "Genomic screening identifies novel linkages and provides further evidence for a role of MYH9 in nonsyndromic cleft lip and palate". Eur. J. Hum. Genet. 17 (2): 195–204. PMC 2874967
. PMID 18716610. doi:10.1038/ejhg.2008.149.
- Mazerbourg S، Sangkuhl K، Luo CW، وآخرون. (2005). "Identification of receptors and signaling pathways for orphan bone morphogenetic protein/growth differentiation factor ligands based on genomic analyses". J. Biol. Chem. 280 (37): 32122–32. PMID 16049014. doi:10.1074/jbc.M504629200.
- Storm EE، Huynh TV، Copeland NG، وآخرون. (1994). "Limb alterations in brachypodism mice due to mutations in a new member of the TGF beta-superfamily". Nature. 368 (6472): 639–43. PMID 8145850. doi:10.1038/368639a0.
- Zhang X، Li S، Xiao X، وآخرون. (2009). "Mutational screening of 10 genes in Chinese patients with microphthalmia and/or coloboma". Mol. Vis. 15: 2911–8. PMC 2802294
. PMID 20057906.
- Erlacher L، McCartney J، Piek E، وآخرون. (1998). "Cartilage-derived morphogenetic proteins and osteogenic protein-1 differentially regulate osteogenesis". J. Bone Miner. Res. 13 (3): 383–92. PMID 9525338. doi:10.1359/jbmr.1998.13.3.383.
- Tassabehji M، Fang ZM، Hilton EN، وآخرون. (2008). "Mutations in GDF6 are associated with vertebral segmentation defects in Klippel-Feil syndrome". Hum. Mutat. 29 (8): 1017–27. PMID 18425797. doi:10.1002/humu.20741.
- Wolfman NM، Hattersley G، Cox K، وآخرون. (1997). "Ectopic induction of tendon and ligament in rats by growth and differentiation factors 5, 6, and 7, members of the TGF-beta gene family". J. Clin. Invest. 100 (2): 321–30. PMC 508194
. PMID 9218508. doi:10.1172/JCI119537.
- Tomaski SM، Zalzal GH (1999). "In vitro regulation of expression of cartilage-derived morphogenetic proteins by growth hormone and insulinlike growth factor 1 in the bovine cricoid chondrocyte". Arch. Otolaryngol. Head Neck Surg. 125 (8): 901–6. PMID 10448738. doi:10.1001/archotol.125.8.901.
- Asai-Coakwell M، French CR، Ye M، وآخرون. (2009). "Incomplete penetrance and phenotypic variability characterize Gdf6-attributable oculo-skeletal phenotypes". Hum. Mol. Genet. 18 (6): 1110–21. PMID 19129173. doi:10.1093/hmg/ddp008.
- Bobacz K، Gruber R، Soleiman A، وآخرون. (2002). "Cartilage-derived morphogenetic protein-1 and -2 are endogenously expressed in healthy and osteoarthritic human articular chondrocytes and stimulate matrix synthesis". Osteoarthr. Cartil. 10 (5): 394–401. PMID 12027540. doi:10.1053/joca.2002.0522.
- Gajavelli S، Wood PM، Pennica D، وآخرون. (2004). "BMP signaling initiates a neural crest differentiation program in embryonic rat CNS stem cells". Exp. Neurol. 188 (2): 205–23. PMID 15246821. doi:10.1016/j.expneurol.2004.03.026.
- Gerhard DS، Wagner L، Feingold EA، وآخرون. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. PMC 528928
. PMID 15489334. doi:10.1101/gr.2596504.
- Chang SC، Hoang B، Thomas JT، وآخرون. (1994). "Cartilage-derived morphogenetic proteins. New members of the transforming growth factor-beta superfamily predominantly expressed in long bones during human embryonic development". J. Biol. Chem. 269 (45): 28227–34. PMID 7961761.
- Reddi AH (1995). "Cartilage morphogenesis: role of bone and cartilage morphogenetic proteins, homeobox genes and extracellular matrix". Matrix Biol. 14 (8): 599–606. PMID 9057810. doi:10.1016/S0945-053X(05)80024-1.
- Strausberg RL، Feingold EA، Grouse LH، وآخرون. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241
. PMID 12477932. doi:10.1073/pnas.242603899.
- Shen B، Bhargav D، Wei A، وآخرون. (2009). "BMP-13 Emerges as a Potential Inhibitor of Bone Formation". Int. J. Biol. Sci. 5 (2): 192–200. PMC 2646266
. PMID 19240811. doi:10.7150/ijbs.5.192.
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