DMP1
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هذا القسم فارغ أو غير مكتمل، ساهم بتحريره.
هذا القسم فارغ أو غير مكتمل، ساهم بتحريره.
DMP1 (Dentin matrix acidic phosphoprotein 1) هوَ بروتين يُشَفر بواسطة جين DMP1 في الإنسان.[1][2][2][3]
الوظيفة[عدل]
هذا القسم فارغ أو غير مكتمل، ساهم بتحريره.الأهمية السريرية[عدل]
هذا القسم فارغ أو غير مكتمل، ساهم بتحريره.المراجع[عدل]
- ^ Hirst KL، Simmons D، Feng J، Aplin H، Dixon MJ، MacDougall M (Jul 1997). "Elucidation of the sequence and the genomic organization of the human dentin matrix acidic phosphoprotein 1 (DMP1) gene: exclusion of the locus from a causative role in the pathogenesis of dentinogenesis imperfecta type II". Genomics. 42 (1): 38–45. PMID 9177774. doi:10.1006/geno.1997.4700.
- ↑ أ ب "Entrez Gene: DMP1 dentin matrix acidic phosphoprotein".
- ^ Aplin HM، Hirst KL، Crosby AH، Dixon MJ (Mar 1996). "Mapping of the human dentin matrix acidic phosphoprotein gene (DMP1) to the dentinogenesis imperfecta type II critical region at chromosome 4q21". Genomics. 30 (2): 347–9. PMID 8586437. doi:10.1006/geno.1995.9867.
قراءة متعمقة[عدل]
- George A، Sabsay B، Simonian PA، Veis A (1993). "Characterization of a novel dentin matrix acidic phosphoprotein. Implications for induction of biomineralization.". J. Biol. Chem. 268 (17): 12624–30. PMID 8509401.
- Hillier LD، Lennon G، Becker M، وآخرون. (1997). "Generation and analysis of 280,000 human expressed sequence tags.". Genome Res. 6 (9): 807–28. PMID 8889549. doi:10.1101/gr.6.9.807.
- Srinivasan R، Chen B، Gorski JP، George A (2000). "Recombinant expression and characterization of dentin matrix protein 1.". Connect. Tissue Res. 40 (4): 251–8. PMID 10757113. doi:10.3109/03008209909000703.
- Kulkarni GV، Chen B، Malone JP، وآخرون. (2000). "Promotion of selective cell attachment by the RGD sequence in dentine matrix protein 1.". Arch. Oral Biol. 45 (6): 475–84. PMID 10775676. doi:10.1016/S0003-9969(00)00010-8.
- Jain A، Karadag A، Fohr B، وآخرون. (2002). "Three SIBLINGs (small integrin-binding ligand, N-linked glycoproteins) enhance factor H's cofactor activity enabling MCP-like cellular evasion of complement-mediated attack.". J. Biol. Chem. 277 (16): 13700–8. PMID 11825898. doi:10.1074/jbc.M110757200.
- Papagerakis P، Berdal A، Mesbah M، وآخرون. (2002). "Investigation of osteocalcin, osteonectin, and dentin sialophosphoprotein in developing human teeth.". Bone. 30 (2): 377–85. PMID 11856645. doi:10.1016/S8756-3282(01)00683-4.
- Strausberg RL، Feingold EA، Grouse LH، وآخرون. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241
. PMID 12477932. doi:10.1073/pnas.242603899. - Narayanan K، Ramachandran A، Hao J، وآخرون. (2003). "Dual functional roles of dentin matrix protein 1. Implications in biomineralization and gene transcription by activation of intracellular Ca2+ store". J. Biol. Chem. 278 (19): 17500–8. PMID 12615915. doi:10.1074/jbc.M212700200.
- Chaplet M، De Leval L، Waltregny D، وآخرون. (2004). "Dentin matrix protein 1 is expressed in human lung cancer". J. Bone Miner. Res. 18 (8): 1506–12. PMID 12929940. doi:10.1359/jbmr.2003.18.8.1506.
- Steiglitz BM، Ayala M، Narayanan K، وآخرون. (2004). "Bone morphogenetic protein-1/Tolloid-like proteinases process dentin matrix protein-1". J. Biol. Chem. 279 (2): 980–6. PMID 14578349. doi:10.1074/jbc.M310179200.
- Toyosawa S، Tomita Y، Kishino M، وآخرون. (2004). "Expression of dentin matrix protein 1 in tumors causing oncogenic osteomalacia". Mod. Pathol. 17 (5): 573–8. PMID 15001995. doi:10.1038/modpathol.3800084.
- Chen S، Inozentseva-Clayton N، Dong J، وآخرون. (2005). "Binding of two nuclear factors to a novel silencer element in human dentin matrix protein 1 (DMP1) promoter regulates the cell type-specific DMP1 gene expression". J. Cell. Biochem. 92 (2): 332–49. PMID 15108359. doi:10.1002/jcb.20051.
- Ogbureke KU، Fisher LW (2004). "Expression of SIBLINGs and their partner MMPs in salivary glands". J. Dent. Res. 83 (9): 664–70. PMID 15329369. doi:10.1177/154405910408300902.
- Yang W، Lu Y، Kalajzic I، وآخرون. (2005). "Dentin matrix protein 1 gene cis-regulation: use in osteocytes to characterize local responses to mechanical loading in vitro and in vivo". J. Biol. Chem. 280 (21): 20680–90. PMID 15728181. doi:10.1074/jbc.M500104200.
- Ogbureke KU، Fisher LW (2005). "Renal expression of SIBLING proteins and their partner matrix metalloproteinases (MMPs)". Kidney Int. 68 (1): 155–66. PMID 15954904. doi:10.1111/j.1523-1755.2005.00389.x.
- Ling Y، Rios HF، Myers ER، وآخرون. (2006). "DMP1 Depletion Decreases Bone Mineralization In Vivo: An FTIR Imaging Analysis". J. Bone Miner. Res. 20 (12): 2169–77. PMC 1456072. PMID 16294270. doi:10.1359/JBMR.050815.
- Karadag A، Fedarko NS، Fisher LW (2006). "Dentin Matrix Protein 1 Enhances Invasion Potential of Colon Cancer Cells by Bridging Matrix Metalloproteinase-9 to Integrins and CD44". Cancer Res. 65 (24): 11545–52. PMC 1350722. PMID 16357164. doi:10.1158/0008-5472.CAN-05-2861.
- Qin C، Huang B، Wygant JN، وآخرون. (2006). "A chondroitin sulfate chain attached to the bone dentin matrix protein 1 NH2-terminal fragment". J. Biol. Chem. 281 (12): 8034–40. PMID 16421105. doi:10.1074/jbc.M512964200.
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