SFRP2

SFRP2
المعرفات
الأسماء المستعارة	SFRP2, FRP-2, SARP1, SDF-5, secreted frizzled related protein 2
معرفات خارجية	MGI: MGI:108078 HomoloGene: 56438 GeneCards: 6423
علم الوجود الجيني الوظيفة الجزيئية • fibronectin binding • receptor ligand activity • endopeptidase activator activity • integrin binding • enzyme activator activity • G-protein coupled receptor activity • Wnt-protein binding • Wnt-activated receptor activity المكونات الخلوية • نسيج خارج الخلية • منطقة خارج الخلية • extracellular space • مكون تكاملي للغشاء • collagen-containing extracellular matrix العمليات الحيوية • cellular response to extracellular stimulus • positive regulation of endopeptidase activity • Wnt signaling pathway involved in somitogenesis • تكون الجسيدات • تمايز خلوي • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • male gonad development • regulation of establishment of planar polarity • response to nutrient • collagen fibril organization • convergent extension involved in axis elongation • development of primary male sexual characteristics • positive regulation of canonical Wnt signaling pathway • negative regulation of mesodermal cell fate specification • cellular response to X-ray • cell-cell signaling • negative regulation of Wnt signaling pathway • bone morphogenesis • hematopoietic stem cell proliferation • chondrocyte development • embryonic digit morphogenesis • outflow tract morphogenesis • cardiac left ventricle morphogenesis • negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage • Wnt signaling pathway • negative regulation of gene expression • sclerotome development • positive regulation of peptidyl-serine phosphorylation • positive regulation of angiogenesis • planar cell polarity pathway involved in neural tube closure • negative regulation of BMP signaling pathway • multicellular organism development • negative regulation of cardiac muscle cell apoptotic process • regulation of apoptotic process • positive regulation of cell growth • neural tube closure • negative regulation of peptidyl-tyrosine phosphorylation • negative regulation of cell migration • positive regulation of osteoblast differentiation • regulation of Wnt signaling pathway • cartilage development • regulation of cell proliferation • regulation of stem cell division • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors • negative regulation of cell growth • neural tube development • positive regulation of cell proliferation • negative regulation of epithelial cell proliferation • positive regulation of apoptotic process • branching involved in blood vessel morphogenesis • post-anal tail morphogenesis • negative regulation of dermatome development • negative regulation of planar cell polarity pathway involved in axis elongation • positive regulation of cell adhesion mediated by integrin • negative regulation of transcription, DNA-templated • negative regulation of JUN kinase activity • positive regulation of fat cell differentiation • negative regulation of epithelial to mesenchymal transition • response to drug • negative regulation of cell proliferation • positive regulation of transcription from RNA polymerase II promoter • digestive tract morphogenesis • anterior/posterior pattern specification • استماتة • negative regulation of canonical Wnt signaling pathway • regulation of midbrain dopaminergic neuron differentiation • regulation of neuron projection development • G-protein coupled receptor signaling pathway • non-canonical Wnt signaling pathway • regulation of receptor activity • canonical Wnt signaling pathway المصادر:Amigo / QuickGO
نمط التعبير عن الحمض النووي الريبوزي
المزيد من بيانات التعبير المرجعية
أورثولوج
الأنواع	الإنسان	الفأر
أنتريه	6423	20319
Ensembl	ENSG00000145423	ENSMUSG00000027996
يونيبروت	Q96HF1	P97299
RefSeq (مرسال ر.ن.ا.)	NM_003013	‏XM_006501183 NM_009144، ‏XM_006501183
RefSeq (بروتين)	NP_003004	‏XP_006501246 NP_033170، ‏XP_006501246
الموقع (UCSC	n/a	Chr 3: 83.77 – 83.77 Mb
بحث ببمد	[1]	[2]
ويكي بيانات
اعرض/عدّل إنسان اعرض/عدّل فأر

SFRP2‏ (Secreted frizzled related protein 2) هوَ بروتين يُشَفر بواسطة جين SFRP2 في الإنسان.

الوظيفة

هذا القسم فارغ أو غير مكتمل، ساهم بتحريره.

الأهمية السريرية

هذا القسم فارغ أو غير مكتمل، ساهم بتحريره.

قراءة متعمقة

• Rattner A، Hsieh JC، Smallwood PM، وآخرون. (1997). "A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors". Proc. Natl. Acad. Sci. U.S.A. 94 (7): 2859–63. PMC 20287. PMID 9096311. doi:10.1073/pnas.94.7.2859. 
• Hu E، Zhu Y، Fredrickson T، وآخرون. (1998). "Tissue restricted expression of two human Frzbs in preadipocytes and pancreas". Biochem. Biophys. Res. Commun. 247 (2): 287–93. PMID 9642118. doi:10.1006/bbrc.1998.8784. 
• Lescher B، Haenig B، Kispert A (1999). "sFRP-2 is a target of the Wnt-4 signaling pathway in the developing metanephric kidney". Dev. Dyn. 213 (4): 440–51. PMID 9853965. doi:10.1002/(SICI)1097-0177(199812)213:4<440::AID-AJA9>3.0.CO;2-6. 
• Chang JT، Esumi N، Moore K، وآخرون. (1999). "Cloning and characterization of a secreted frizzled-related protein that is expressed by the retinal pigment epithelium". Hum. Mol. Genet. 8 (4): 575–83. PMID 10072424. doi:10.1093/hmg/8.4.575. 
• Lee CS، Buttitta LA، May NR، وآخرون. (2000). "SHH-N upregulates Sfrp2 to mediate its competitive interaction with WNT1 and WNT4 in the somitic mesoderm". Development. 127 (1): 109–18. PMID 10654605. 
• Strausberg RL، Feingold EA، Grouse LH، وآخرون. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241. PMID 12477932. doi:10.1073/pnas.242603899. 
• Clark HF، Gurney AL، Abaya E، وآخرون. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. PMC 403697. PMID 12975309. doi:10.1101/gr.1293003. 
• Brophy PD، Lang KM، Dressler GR (2004). "The secreted frizzled related protein 2 (SFRP2) gene is a target of the Pax2 transcription factor". J. Biol. Chem. 278 (52): 52401–5. PMID 14561758. doi:10.1074/jbc.M305614200. 
• Ota T، Suzuki Y، Nishikawa T، وآخرون. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285. 
• Lee JL، Lin CT، Chueh LL، Chang CJ (2004). "Autocrine/paracrine secreted Frizzled-related protein 2 induces cellular resistance to apoptosis: a possible mechanism of mammary tumorigenesis". J. Biol. Chem. 279 (15): 14602–9. PMID 14709558. doi:10.1074/jbc.M309008200. 
• Müller HM، Oberwalder M، Fiegl H، وآخرون. (2004). "Methylation changes in faecal DNA: a marker for colorectal cancer screening?". Lancet. 363 (9417): 1283–5. PMID 15094274. doi:10.1016/S0140-6736(04)16002-9. 
• Brandenberger R، Wei H، Zhang S، وآخرون. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. PMID 15146197. doi:10.1038/nbt971. 
• Zhang Z، Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. PMC 2286551. PMID 15340161. doi:10.1110/ps.04682504. 
• Gerhard DS، Wagner L، Feingold EA، وآخرون. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. PMC 528928. PMID 15489334. doi:10.1101/gr.2596504. 
• Otsuki T، Ota T، Nishikawa T، وآخرون. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. PMID 16303743. doi:10.1093/dnares/12.2.117. 
• Clément G، Braunschweig R، Pasquier N، وآخرون. (2006). "Alterations of the Wnt signaling pathway during the neoplastic progression of Barrett's esophagus". Oncogene. 25 (21): 3084–92. PMID 16407829. doi:10.1038/sj.onc.1209338. 
• Urakami S، Shiina H، Enokida H، وآخرون. (2006). "Combination analysis of hypermethylated Wnt-antagonist family genes as a novel epigenetic biomarker panel for bladder cancer detection". Clin. Cancer Res. 12 (7 Pt 1): 2109–16. PMID 16609023. doi:10.1158/1078-0432.CCR-05-2468. 
• Olsen JV، Blagoev B، Gnad F، وآخرون. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. PMID 17081983. doi:10.1016/j.cell.2006.09.026. 
• Huang ZH، Li LH، Yang F، Wang JF (2007). "Detection of aberrant methylation in fecal DNA as a molecular screening tool for colorectal cancer and precancerous lesions". World J. Gastroenterol. 13 (6): 950–4. PMID 17352030. doi:10.3748/wjg.v13.i6.950. 
• Veeck J، Noetzel E، Bektas N، Jost E، Hartmann A، Knuchel R، Dahl E (2008). "Promoter hypermethylation of the SFRP2 gene is a high-frequent alteration and tumor-specific epigenetic marker in human breast cancer". Mol Cancer. 7 (83): 83. PMC 2613402. PMID 18990230. doi:10.1186/1476-4598-7-83. 

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