ACTR3

Actin related protein 3
المعرفات
الأسماء المستعارة	actin-related protein 3, ARP3 actin related protein 3 homolog, ACTR3, actin-like protein 3
معرفات خارجية
أورثولوج
	n/a
	n/a
	n/a
	n/a
	n/a
	n/a
	ويكي بيانات
اعرض/عدّل إنسان

ACTR3‏ (ARP3 actin related protein 3 homolog) هوَ بروتين يُشَفر بواسطة جين ACTR3 في الإنسان.^[1]

الوظيفة[عدل]

الأهمية السريرية[عدل]

المراجع[عدل]

^ Welch MD، DePace AH، Verma S، Iwamatsu A، Mitchison TJ (يوليو 1997). "The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly". The Journal of Cell Biology. ج. 138 ع. 2: 375–84. DOI:10.1083/jcb.138.2.375. PMC:2138188. PMID:9230079.

قراءة متعمقة[عدل]

Welch MD، Iwamatsu A، Mitchison TJ (يناير 1997). "Actin polymerization is induced by Arp2/3 protein complex at the surface of Listeria monocytogenes". Nature. ج. 385 ع. 6613: 265–9. DOI:10.1038/385265a0. PMID:9000076.
Winter D، Podtelejnikov AV، Mann M، Li R (يوليو 1997). "The complex containing actin-related proteins Arp2 and Arp3 is required for the motility and integrity of yeast actin patches". Current Biology. ج. 7 ع. 7: 519–29. DOI:10.1016/S0960-9822(06)00223-5. PMID:9210376.
Machesky LM، Reeves E، Wientjes F، Mattheyse FJ، Grogan A، Totty NF، Burlingame AL، Hsuan JJ، Segal AW (نوفمبر 1997). "Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily conserved proteins". The Biochemical Journal. 328 ( Pt 1) ع. 1: 105–12. PMC:1218893. PMID:9359840.
Ma L، Rohatgi R، Kirschner MW (ديسمبر 1998). "The Arp2/3 complex mediates actin polymerization induced by the small GTP-binding protein Cdc42". Proceedings of the National Academy of Sciences of the United States of America. ج. 95 ع. 26: 15362–7. DOI:10.1073/pnas.95.26.15362. PMC:28048. PMID:9860974.
Machesky LM، Insall RH (1999). "Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex". Current Biology. ج. 8 ع. 25: 1347–56. DOI:10.1016/S0960-9822(98)00015-3. PMID:9889097.
Suetsugu S، Miki H، Takenawa T (يونيو 1999). "Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex". Biochemical and Biophysical Research Communications. ج. 260 ع. 1: 296–302. DOI:10.1006/bbrc.1999.0894. PMID:10381382.
May RC، Hall ME، Higgs HN، Pollard TD، Chakraborty T، Wehland J، Machesky LM، Sechi AS (يوليو 1999). "The Arp2/3 complex is essential for the actin-based motility of Listeria monocytogenes". Current Biology. ج. 9 ع. 14: 759–62. DOI:10.1016/S0960-9822(99)80337-6. PMID:10421578.
Loisel TP، Boujemaa R، Pantaloni D، Carlier MF (أكتوبر 1999). "Reconstitution of actin-based motility of Listeria and Shigella using pure proteins". Nature. ج. 401 ع. 6753: 613–6. DOI:10.1038/44183. PMID:10524632.
Higgs HN، Blanchoin L، Pollard TD (نوفمبر 1999). "Influence of the C terminus of Wiskott-Aldrich syndrome protein (WASp) and the Arp2/3 complex on actin polymerization". Biochemistry. ج. 38 ع. 46: 15212–22. DOI:10.1021/bi991843. PMID:10563804.
Carlier MF، Nioche P، Broutin-L'Hermite I، Boujemaa R، Le Clainche C، Egile C، Garbay C، Ducruix A، Sansonetti P، Pantaloni D (يوليو 2000). "GRB2 links signaling to actin assembly by enhancing interaction of neural Wiskott-Aldrich syndrome protein (N-WASp) with actin-related protein (ARP2/3) complex". The Journal of Biological Chemistry. ج. 275 ع. 29: 21946–52. DOI:10.1074/jbc.M000687200. PMID:10781580.
Jay P، Bergé-Lefranc JL، Massacrier A، Roessler E، Wallis D، Muenke M، Gastaldi M، Taviaux S، Cau P، Berta P (مايو 2000). "ARP3beta, the gene encoding a new human actin-related protein, is alternatively spliced and predominantly expressed in brain neuronal cells". European Journal of Biochemistry / FEBS. ج. 267 ع. 10: 2921–8. DOI:10.1046/j.1432-1327.2000.01306.x. PMID:10806390.
Weed SA، Karginov AV، Schafer DA، Weaver AM، Kinley AW، Cooper JA، Parsons JT (أكتوبر 2000). "Cortactin localization to sites of actin assembly in lamellipodia requires interactions with F-actin and the Arp2/3 complex". The Journal of Cell Biology. ج. 151 ع. 1: 29–40. DOI:10.1083/jcb.151.1.29. PMC:2189811. PMID:11018051.
Prehoda KE، Scott JA، Mullins RD، Lim WA (أكتوبر 2000). "Integration of multiple signals through cooperative regulation of the N-WASP-Arp2/3 complex". Science. ج. 290 ع. 5492: 801–6. DOI:10.1126/science.290.5492.801. PMID:11052943.
Marchand JB، Kaiser DA، Pollard TD، Higgs HN (يناير 2001). "Interaction of WASP/Scar proteins with actin and vertebrate Arp2/3 complex". Nature Cell Biology. ج. 3 ع. 1: 76–82. DOI:10.1038/35050590. PMID:11146629.
Zhao X، Yang Z، Qian M، Zhu X (يناير 2001). "Interactions among subunits of human Arp2/3 complex: p20-Arc as the hub". Biochemical and Biophysical Research Communications. ج. 280 ع. 2: 513–7. DOI:10.1006/bbrc.2000.4151. PMID:11162547.
Robinson RC، Turbedsky K، Kaiser DA، Marchand JB، Higgs HN، Choe S، Pollard TD (نوفمبر 2001). "Crystal structure of Arp2/3 complex". Science. ج. 294 ع. 5547: 1679–84. DOI:10.1126/science.1066333. PMID:11721045.
Gournier H، Goley ED، Niederstrasser H، Trinh T، Welch MD (نوفمبر 2001). "Reconstitution of human Arp2/3 complex reveals critical roles of individual subunits in complex structure and activity". Molecular Cell. ج. 8 ع. 5: 1041–52. DOI:10.1016/S1097-2765(01)00393-8. PMID:11741539.
Andersen JS، Lyon CE، Fox AH، Leung AK، Lam YW، Steen H، Mann M، Lamond AI (يناير 2002). "Directed proteomic analysis of the human nucleolus". Current Biology. ج. 12 ع. 1: 1–11. DOI:10.1016/S0960-9822(01)00650-9. PMID:11790298.
Kovacs EM، Goodwin M، Ali RG، Paterson AD، Yap AS (مارس 2002). "Cadherin-directed actin assembly: E-cadherin physically associates with the Arp2/3 complex to direct actin assembly in nascent adhesive contacts". Current Biology. ج. 12 ع. 5: 379–82. DOI:10.1016/S0960-9822(02)00661-9. PMID:11882288.