SCG2

SCG2
المعرفات
الأسماء المستعارة	SCG2, CHGC, EM66, SN, SgII, secretogranin II
معرفات خارجية	الوراثة المندلية البشرية عبر الإنترنت 118930 MGI: MGI:103033 HomoloGene: 2591 GeneCards: 7857
علم الوجود الجيني الوظيفة الجزيئية • ‏GO:0001948 ربط بروتيني • chemoattractant activity • cytokine activity المكونات الخلوية • منطقة خارج الخلية • dense core granule • حبيبة إفرازية • خارج خلوي • neuronal dense core vesicle • endoplasmic reticulum lumen العمليات الحيوية • protein secretion • induction of positive chemotaxis • negative regulation of endothelial cell apoptotic process • eosinophil chemotaxis • positive chemotaxis • negative regulation of extrinsic apoptotic signaling pathway • ‏GO:0007243 intracellular signal transduction • inflammatory response • positive regulation of endothelial cell proliferation • endothelial cell migration • توليد الأوعية • MAPK cascade • negative regulation of endothelial cell proliferation • تعديل ما بعد الترجمة • عملية التمثيل الغذائي للبروتين الخلوي • regulation of signaling receptor activity المصادر:Amigo / QuickGO
أورثولوج
الأنواع	الإنسان	الفأر
أنتريه	7857	20254
Ensembl	ENSG00000171951	ENSMUSG00000050711
يونيبروت	P13521 P15321	Q03517
RefSeq (مرسال ر.ن.ا.)	NM_003469	‏NM_001310680 NM_009129، ‏NM_001310680
RefSeq (بروتين)	NP_003460	‏NP_033155 NP_001297609، ‏NP_033155
الموقع (UCSC	n/a
بحث ببمد	[1]	[2]
ويكي بيانات
اعرض/عدّل إنسان اعرض/عدّل فأر

SCG2‏ (Secretogranin II) هوَ بروتين يُشَفر بواسطة جين SCG2 في الإنسان.

الوظيفة

هذا القسم فارغ أو غير مكتمل، ساهم بتحريره.

الأهمية السريرية

هذا القسم فارغ أو غير مكتمل، ساهم بتحريره.

قراءة متعمقة

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• Ozawa H, Takata K (1995). "The granin family--its role in sorting and secretory granule formation". Cell Struct. Funct. 20 (6): 415–20. doi:10.1247/csf.20.415. PMID 8825061.
• Huttner WB, Gerdes HH, Rosa P (1991). "The granin (chromogranin/secretogranin) family". Trends Biochem. Sci. 16 (1): 27–30. doi:10.1016/0968-0004(91)90012-K. PMID 2053134.
• Stemberger K, Pallhuber J, Doblinger A, et al. (2004). "Secretoneurin in the human aqueous humor and the absence of an effect of frequently used eye drops on the levels". Peptides. 25 (12): 2115–8. doi:10.1016/j.peptides.2004.08.010. PMID 15572199.
• Scammell JG, Reddy S, Valentine DL, et al. (2000). "Isolation and characterization of the human secretogranin II gene promoter". Brain Res. Mol. Brain Res. 75 (1): 8–15. doi:10.1016/S0169-328X(99)00269-7. PMID 10648883.
• Kähler CM, Schratzberger P, Kaufmann G, et al. (2002). "Transendothelial migration of leukocytes and signalling mechanisms in response to the neuropeptide secretoneurin". Regul. Pept. 105 (1): 35–46. doi:10.1016/S0167-0115(01)00379-2. PMID 11853870.
• Beranova-Giorgianni S, Zhao Y, Desiderio DM, Giorgianni F (2006). "Phosphoproteomic analysis of the human pituitary". Pituitary. 9 (2): 109–20. doi:10.1007/s11102-006-8916-x. PMID 16807684.
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• Kato A, Kammen-Jolly K, Fischer-Colbie R, et al. (2000). "Co-distribution patterns of chromogranin B-like immunoreactivity with chromogranin A and secretoneurin within the human brainstem". Brain Res. 852 (2): 444–52. doi:10.1016/S0006-8993(99)02229-5. PMID 10678772.
• Schrott-Fischer A, Bitsche M, Humpel C, et al. (2009). "Chromogranin peptides in amyotrophic lateral sclerosis". Regul. Pept. 152 (1–3): 13–21. doi:10.1016/j.regpep.2008.07.009. PMID 18721831.
• Fischer-Colbrie R, Kirchmair R, Kähler CM, et al. (2005). "Secretoneurin: a new player in angiogenesis and chemotaxis linking nerves, blood vessels and the immune system". Curr. Protein Pept. Sci. 6 (4): 373–85. doi:10.2174/1389203054546334. PMID 16101435.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
• Lankat-Buttgereit B, Müller S, Schmidt H, et al. (2008). "Knockdown of Pdcd4 results in induction of proprotein convertase 1/3 and potent secretion of chromogranin A and secretogranin II in a neuroendocrine cell line". Biol. Cell. 100 (12): 703–15. doi:10.1042/BC20080052. PMID 18549351.
• Stridsberg M, Eriksson B, Janson ET (2008). "Measurements of secretogranins II, III, V and proconvertases 1/3 and 2 in plasma from patients with neuroendocrine tumours". Regul. Pept. 148 (1–3): 95–8. doi:10.1016/j.regpep.2008.03.007. PMID 18448176.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wen G, Wessel J, Zhou W, et al. (2007). "An ancestral variant of Secretogranin II confers regulation by PHOX2 transcription factors and association with hypertension". Hum. Mol. Genet. 16 (14): 1752–64. doi:10.1093/hmg/ddm123. PMC 2695823. PMID 17584765.
• Yon L, Guillemot J, Montero-Hadjadje M, et al. (2003). "Identification of the secretogranin II-derived peptide EM66 in pheochromocytomas as a potential marker for discriminating benign versus malignant tumors". J. Clin. Endocrinol. Metab. 88 (6): 2579–85. doi:10.1210/jc.2002-021748. PMID 12788858.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Wu C, Ma MH, Brown KR, et al. (2007). "Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening". Proteomics. 7 (11): 1775–85. doi:10.1002/pmic.200601006. PMID 17474147.
• Li L, Hung AC, Porter AG (2008). "Secretogranin II: a key AP-1-regulated protein that mediates neuronal differentiation and protection from nitric oxide-induced apoptosis of neuroblastoma cells". Cell Death Differ. 15 (5): 879–88. doi:10.1038/cdd.2008.8. PMID 18239671.

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