IKZF2
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هذا القسم فارغ أو غير مكتمل، ساهم بتحريره.
هذا القسم فارغ أو غير مكتمل، ساهم بتحريره.
IKZF2 (IKAROS family zinc finger 2) هوَ بروتين يُشَفر بواسطة جين IKZF2 في الإنسان.[1][2][3]
الوظيفة[عدل]

الأهمية السريرية[عدل]

المراجع[عدل]
- ^ Hahm K، Cobb BS، McCarty AS، Brown KE، Klug CA، Lee R، Akashi K، Weissman IL، Fisher AG، Smale ST (Mar 1998). "Helios, a T cell-restricted Ikaros family member that quantitatively associates with Ikaros at centromeric heterochromatin". Genes & Development. 12 (6): 782–96. PMC 316626
. PMID 9512513. doi:10.1101/gad.12.6.782.
- ^ "Entrez Gene: IKZF2 IKAROS family zinc finger 2 (Helios)".
- ^ Kelley CM، Ikeda T، Koipally J، Avitahl N، Wu L، Georgopoulos K، Morgan BA (Apr 1998). "Helios, a novel dimerization partner of Ikaros expressed in the earliest hematopoietic progenitors". Current Biology. 8 (9): 508–15. PMID 9560339. doi:10.1016/S0960-9822(98)70202-7.
قراءة متعمقة[عدل]
- Rebollo A، Schmitt C (Jun 2003). "Ikaros, Aiolos and Helios: transcription regulators and lymphoid malignancies". Immunology and Cell Biology. 81 (3): 171–5. PMID 12752680. doi:10.1046/j.1440-1711.2003.01159.x.
- Sridharan R، Smale ST (Oct 2007). "Predominant interaction of both Ikaros and Helios with the NuRD complex in immature thymocytes". The Journal of Biological Chemistry. 282 (41): 30227–38. PMID 17681952. doi:10.1074/jbc.M702541200.
- Tabayashi T، Ishimaru F، Takata M، Kataoka I، Nakase K، Kozuka T، Tanimoto M (Feb 2007). "Characterization of the short isoform of Helios overexpressed in patients with T-cell malignancies". Cancer Science. 98 (2): 182–8. PMID 17297655. doi:10.1111/j.1349-7006.2006.00372.x.
- Sun L، Kerawalla H، Wu X، Lehnert MS، Uckun FM (Apr 2002). "Expression of a unique helios isoform in human leukemia cells". Leukemia & Lymphoma. 43 (4): 841–9. PMID 12153174. doi:10.1080/10428190290016980.
- Durand C، Kerfourn F، Charlemagne J، Fellah JS (Jun 2002). "Identification and expression of Helios, a member of the Ikaros family, in the Mexican axolotl: implications for the embryonic origin of lymphocyte progenitors". European Journal of Immunology. 32 (6): 1748–52. PMID 12115658. doi:10.1002/1521-4141(200206)32:6<1748::AID-IMMU1748>3.0.CO;2-B.
- Nakase K، Ishimaru F، Fujii K، Tabayashi T، Kozuka T، Sezaki N، Matsuo Y، Harada M (Apr 2002). "Overexpression of novel short isoforms of Helios in a patient with T-cell acute lymphoblastic leukemia". Experimental Hematology. 30 (4): 313–7. PMID 11937265. doi:10.1016/S0301-472X(01)00796-2.
- Perdomo J، Holmes M، Chong B، Crossley M (Dec 2000). "Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities". The Journal of Biological Chemistry. 275 (49): 38347–54. PMID 10978333. doi:10.1074/jbc.M005457200.
- Hosokawa Y، Maeda Y، Seto M (Oct 1999). "Human Helios, an Ikaros-related zinc finger DNA binding protein: cDNA cloning and tissue expression pattern". Immunogenetics. 50 (1-2): 106–8. PMID 10541817. doi:10.1007/s002510050696.
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