IGFBP5

IGFBP5
التراكيب المتوفرة بنك بيانات البروتين Ortholog search: PDBe RCSB قائمة رموز معرفات بنك بيانات البروتين 1BOE, 1H59
المعرفات
الأسماء المستعارة	IGFBP5, IBP5, insulin like growth factor binding protein 5
معرفات خارجية	الوراثة المندلية البشرية عبر الإنترنت 146734 MGI: MGI:96440 HomoloGene: 56489 GeneCards: 3488
علم الوجود الجيني الوظيفة الجزيئية • fibronectin binding • insulin-like growth factor binding • growth factor binding • insulin-like growth factor I binding • insulin-like growth factor II binding • ‏GO:0001948، ‏GO:0016582 ربط بروتيني المكونات الخلوية • insulin-like growth factor ternary complex • الفراغ خارج الخلية • insulin-like growth factor binding protein complex • endoplasmic reticulum lumen • خارج خلوي العمليات الحيوية • negative regulation of smooth muscle cell proliferation • negative regulation of translation • positive regulation of protein kinase B signaling • ‏GO:0007243 intracellular signal transduction • negative regulation of growth • glucose homeostasis • حمل أنثوي • ‏GO:1904579 cellular response to organic cyclic compound • negative regulation of smooth muscle cell migration • negative regulation of osteoblast differentiation • regulation of glucose metabolic process • negative regulation of cell migration • positive regulation of insulin-like growth factor receptor signaling pathway • regulation of cell growth • osteoblast differentiation • response to growth hormone • glucose metabolic process • negative regulation of insulin-like growth factor receptor signaling pathway • hair follicle morphogenesis • regulation of growth • negative regulation of muscle tissue development • striated muscle cell differentiation • lung alveolus development • negative regulation of skeletal muscle hypertrophy • type B pancreatic cell proliferation • cellular response to cAMP • ‏GO:0072468 توصيل الإشارة • mammary gland involution • ‏GO:0010260 شيخوخة • تعديل ما بعد الترجمة • positive regulation of vascular associated smooth muscle cell proliferation • positive regulation of vascular associated smooth muscle cell migration • regulation of insulin-like growth factor receptor signaling pathway المصادر:Amigo / QuickGO
نمط التعبير عن الحمض النووي الريبوزي
المزيد من بيانات التعبير المرجعية
أورثولوج
الأنواع	الإنسان	الفأر
أنتريه	3488	16011
Ensembl	ENSG00000115461	ENSMUSG00000026185
يونيبروت	P24593	Q07079
RefSeq (مرسال ر.ن.ا.)	NM_000599	NM_010518
RefSeq (بروتين)	NP_000590	NP_034648
الموقع (UCSC	n/a	Chr 1: 72.9 – 72.91 Mb
بحث ببمد	[1]	[2]
ويكي بيانات
اعرض/عدّل إنسان اعرض/عدّل فأر

IGFBP5‏ (Insulin like growth factor binding protein 5) هوَ بروتين يُشَفر بواسطة جين IGFBP5 في الإنسان.

قراءة متعمقة

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• Schneider MR، Wolf E، Hoeflich A، Lahm H (2002). "IGF-binding protein-5: flexible player in the IGF system and effector on its own". J. Endocrinol. ج. 172 ع. 3: 423–40. DOI:10.1677/joe.0.1720423. PMID:11874691.
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• Andress DL، Birnbaum RS (1991). "A novel human insulin-like growth factor binding protein secreted by osteoblast-like cells". Biochem. Biophys. Res. Commun. ج. 176 ع. 1: 213–8. DOI:10.1016/0006-291X(91)90911-P. PMID:1850257.
• Kiefer MC، Ioh RS، Bauer DM، Zapf J (1991). "Molecular cloning of a new human insulin-like growth factor binding protein". Biochem. Biophys. Res. Commun. ج. 176 ع. 1: 219–25. DOI:10.1016/0006-291X(91)90912-Q. PMID:1850258.
• Ilvesmäki V، Blum WF، Voutilainen R (1994). "Insulin-like growth factor binding proteins in the human adrenal gland". Mol. Cell. Endocrinol. ج. 97 ع. 1–2: 71–9. DOI:10.1016/0303-7207(93)90212-3. PMID:7511544.
• Kou K، James PL، Clemmons DR، وآخرون (1994). "Identification of two clusters of mouse insulin-like growth factor binding protein genes on chromosomes 1 and 11". Genomics. ج. 21 ع. 3: 653–5. DOI:10.1006/geno.1994.1329. PMID:7525452.
• Andersson B، Wentland MA، Ricafrente JY، وآخرون (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. ج. 236 ع. 1: 107–13. DOI:10.1006/abio.1996.0138. PMID:8619474.
• Yu W، Andersson B، Worley KC، وآخرون (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. ج. 7 ع. 4: 353–8. DOI:10.1101/gr.7.4.353. PMC:139146. PMID:9110174.
• Nam TJ، Busby W، Clemmons DR (1997). "Insulin-like growth factor binding protein-5 binds to plasminogen activator inhibitor-I". Endocrinology. ج. 138 ع. 7: 2972–8. DOI:10.1210/en.138.7.2972. PMID:9202242.
• Twigg SM، Baxter RC (1998). "Insulin-like growth factor (IGF)-binding protein 5 forms an alternative ternary complex with IGFs and the acid-labile subunit". J. Biol. Chem. ج. 273 ع. 11: 6074–9. DOI:10.1074/jbc.273.11.6074. PMID:9497324.
• Zheng B، Clarke JB، Busby WH، وآخرون (1998). "Insulin-like growth factor-binding protein-5 is cleaved by physiological concentrations of thrombin". Endocrinology. ج. 139 ع. 4: 1708–14. DOI:10.1210/en.139.4.1708. PMID:9528953.
• Twigg SM، Kiefer MC، Zapf J، Baxter RC (1998). "Insulin-like growth factor-binding protein 5 complexes with the acid-labile subunit. Role of the carboxyl-terminal domain". J. Biol. Chem. ج. 273 ع. 44: 28791–8. DOI:10.1074/jbc.273.44.28791. PMID:9786878.
• Kalus W، Zweckstetter M، Renner C، وآخرون (1999). "Structure of the IGF-binding domain of the insulin-like growth factor-binding protein-5 (IGFBP-5): implications for IGF and IGF-I receptor interactions". EMBO J. ج. 17 ع. 22: 6558–72. DOI:10.1093/emboj/17.22.6558. PMC:1171003. PMID:9822601.
• Ständker L، Wobst P، Mark S، Forssmann WG (1999). "Isolation and characterization of circulating 13-kDa C-terminal fragments of human insulin-like growth factor binding protein-5". FEBS Lett. ج. 441 ع. 2: 281–6. DOI:10.1016/S0014-5793(98)01497-5. PMID:9883900.
• Kecha O، Martens H، Franchimont N، وآخرون (1999). "Characterization of the insulin-like growth factor axis in the human thymus". J. Neuroendocrinol. ج. 11 ع. 6: 435–40. DOI:10.1046/j.1365-2826.1999.00343.x. PMID:10336724.