IGFBP5

IGFBP5
التراكيب المتوفرة بنك بيانات البروتين Ortholog search: PDBe RCSB قائمة رموز معرفات بنك بيانات البروتين 1BOE, 1H59
المعرفات
الأسماء المستعارة	IGFBP5, IBP5, insulin like growth factor binding protein 5
معرفات خارجية	الوراثة المندلية البشرية عبر الإنترنت 146734 MGI: MGI:96440 HomoloGene: 56489 GeneCards: 3488
علم الوجود الجيني الوظيفة الجزيئية • fibronectin binding • insulin-like growth factor binding • growth factor binding • insulin-like growth factor I binding • insulin-like growth factor II binding • ‏GO:0001948 ربط بروتيني المكونات الخلوية • insulin-like growth factor ternary complex • منطقة خارج الخلية • insulin-like growth factor binding protein complex • endoplasmic reticulum lumen • خارج خلوي العمليات الحيوية • عملية التمثيل الغذائي للبروتين الخلوي • negative regulation of smooth muscle cell proliferation • negative regulation of translation • positive regulation of protein kinase B signaling • ‏GO:0007243 intracellular signal transduction • negative regulation of growth • glucose homeostasis • حمل أنثوي • cellular response to organic cyclic compound • negative regulation of smooth muscle cell migration • negative regulation of osteoblast differentiation • regulation of glucose metabolic process • negative regulation of cell migration • positive regulation of insulin-like growth factor receptor signaling pathway • regulation of cell growth • osteoblast differentiation • response to growth hormone • glucose metabolic process • negative regulation of insulin-like growth factor receptor signaling pathway • hair follicle morphogenesis • regulation of growth • negative regulation of muscle tissue development • striated muscle cell differentiation • lung alveolus development • negative regulation of skeletal muscle hypertrophy • type B pancreatic cell proliferation • cellular response to cAMP • توصيل الإشارة • mammary gland involution • شيخوخة • تعديل ما بعد الترجمة • positive regulation of vascular associated smooth muscle cell proliferation • positive regulation of vascular associated smooth muscle cell migration • regulation of insulin-like growth factor receptor signaling pathway المصادر:Amigo / QuickGO
نمط التعبير عن الحمض النووي الريبوزي
المزيد من بيانات التعبير المرجعية
أورثولوج
الأنواع	الإنسان	الفأر
أنتريه	3488	16011
Ensembl	ENSG00000115461	ENSMUSG00000026185
يونيبروت	P24593	Q07079
RefSeq (مرسال ر.ن.ا.)	NM_000599	NM_010518
RefSeq (بروتين)	NP_000590	NP_034648
الموقع (UCSC	n/a	Chr 1: 72.86 – 72.87 Mb
بحث ببمد	[1]	[2]
ويكي بيانات
اعرض/عدّل إنسان اعرض/عدّل فأر

IGFBP5‏ (Insulin like growth factor binding protein 5) هوَ بروتين يُشَفر بواسطة جين IGFBP5 في الإنسان.

الوظيفة

هذا القسم فارغ أو غير مكتمل، ساهم بتحريره.

الأهمية السريرية

هذا القسم فارغ أو غير مكتمل، ساهم بتحريره.

قراءة متعمقة

• "Age-related changes in IGFBP-4 and IGFBP-5 levels in human serum and bone: implications for bone loss with aging". Prog. Growth Factor Res. 6 (2–4): 465–73. 1996. doi:10.1016/0955-2235(95)00027-5. PMID 8817691.
• "IGF-binding protein-5: flexible player in the IGF system and effector on its own". J. Endocrinol. 172 (3): 423–40. 2002. doi:10.1677/joe.0.1720423. PMID 11874691.
• "Cellular actions of the insulin-like growth factor binding proteins". Endocr. Rev. 23 (6): 824–54. 2003. doi:10.1210/er.2001-0033. PMID 12466191.
• "Identification of five different insulin-like growth factor binding proteins (IGFBPs) from adult rat serum and molecular cloning of a novel IGFBP-5 in rat and human". J. Biol. Chem. 266 (16): 10646–53. 1991. PMID 1709938.
• "Structure and localization of the human insulin-like growth factor-binding protein 2 gene". Biochem. Biophys. Res. Commun. 176 (3): 1250–5. 1991. doi:10.1016/0006-291X(91)90420-C. PMID 1710112.
• "A novel human insulin-like growth factor binding protein secreted by osteoblast-like cells". Biochem. Biophys. Res. Commun. 176 (1): 213–8. 1991. doi:10.1016/0006-291X(91)90911-P. PMID 1850257.
• "Molecular cloning of a new human insulin-like growth factor binding protein". Biochem. Biophys. Res. Commun. 176 (1): 219–25. 1991. doi:10.1016/0006-291X(91)90912-Q. PMID 1850258.
• "Insulin-like growth factor binding proteins in the human adrenal gland". Mol. Cell. Endocrinol. 97 (1–2): 71–9. 1994. doi:10.1016/0303-7207(93)90212-3. PMID 7511544.
• "Identification of two clusters of mouse insulin-like growth factor binding protein genes on chromosomes 1 and 11". Genomics. 21 (3): 653–5. 1994. doi:10.1006/geno.1994.1329. PMID 7525452.
• "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. 1996. doi:10.1006/abio.1996.0138. PMID 8619474.
• "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. 1997. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• "Insulin-like growth factor binding protein-5 binds to plasminogen activator inhibitor-I". Endocrinology. 138 (7): 2972–8. 1997. doi:10.1210/en.138.7.2972. PMID 9202242.
• "Insulin-like growth factor (IGF)-binding protein 5 forms an alternative ternary complex with IGFs and the acid-labile subunit". J. Biol. Chem. 273 (11): 6074–9. 1998. doi:10.1074/jbc.273.11.6074. PMID 9497324.
• "Insulin-like growth factor-binding protein-5 is cleaved by physiological concentrations of thrombin". Endocrinology. 139 (4): 1708–14. 1998. doi:10.1210/en.139.4.1708. PMID 9528953.
• "Insulin-like growth factor-binding protein 5 complexes with the acid-labile subunit. Role of the carboxyl-terminal domain". J. Biol. Chem. 273 (44): 28791–8. 1998. doi:10.1074/jbc.273.44.28791. PMID 9786878.
• "Structure of the IGF-binding domain of the insulin-like growth factor-binding protein-5 (IGFBP-5): implications for IGF and IGF-I receptor interactions". EMBO J. 17 (22): 6558–72. 1999. doi:10.1093/emboj/17.22.6558. PMC 1171003. PMID 9822601.
• "Isolation and characterization of circulating 13-kDa C-terminal fragments of human insulin-like growth factor binding protein-5". FEBS Lett. 441 (2): 281–6. 1999. doi:10.1016/S0014-5793(98)01497-5. PMID 9883900.
• "Characterization of the insulin-like growth factor axis in the human thymus". J. Neuroendocrinol. 11 (6): 435–40. 1999. doi:10.1046/j.1365-2826.1999.00343.x. PMID 10336724.

هذه بذرة مقالة عن جين على كروموسوم 2 بحاجة للتوسيع. شارك في تحريرها.

IGFBP5 في المشاريع الشقيقة

---

• صور وملفات صوتية من كومنز