REG3A
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هذا القسم فارغ أو غير مكتمل، ساهم بتحريره.
هذا القسم فارغ أو غير مكتمل، ساهم بتحريره.
REG3A (Regenerating family member 3 alpha) هوَ بروتين يُشَفر بواسطة جين REG3A في الإنسان.[1][2][3][3][4][5]
الوظيفة[عدل]

الأهمية السريرية[عدل]

المراجع[عدل]
- ^ Vaishnava، Shipra؛ Yamamoto، Miwako؛ Severson، Kari M.؛ Ruhn، Kelly A.؛ Yu، Xiaofei؛ Koren، Omry؛ Ley، Ruth؛ Wakeland، Edward K.؛ Hooper، Lora V. (2011-10-14). "The antibacterial lectin RegIIIγ promotes the spatial segregation of microbiota and host in the intestine". Science. 334 (6053): 255–258. ISSN 0036-8075. PMC 3321924
. PMID 21998396. doi:10.1126/science.1209791.
- ^ Cash، Heather L.؛ Whitham، Cecilia V.؛ Behrendt، Cassie L.؛ Hooper، Lora V. (2006-08-25). "Symbiotic bacteria direct expression of an intestinal bactericidal lectin". Science. 313 (5790): 1126–1130. ISSN 1095-9203. PMC 2716667
. PMID 16931762. doi:10.1126/science.1127119.
- ↑ أ ب "Entrez Gene: REG3A regenerating islet-derived 3 alpha". مؤرشف من الأصل في 05 ديسمبر 2010.
- ^ Dusetti NJ، Frigerio JM، Fox MF، Swallow DM، Dagorn JC، Iovanna JL (Jun 1994). "Molecular cloning, genomic organization, and chromosomal localization of the human pancreatitis-associated protein (PAP) gene". Genomics. 19 (1): 108–14. PMID 8188210. doi:10.1006/geno.1994.1019.
- ^ Chakraborty C، Sharma S، Katsumata N، Murphy LJ، Schroedter IC، Robertson MC، Shiu RP، Friesen HG (Jun 1995). "Plasma clearance, tissue uptake and expression of pituitary peptide 23/pancreatitis-associated protein in the rat.". Journal of Endocrinology. PMID 7636430.
قراءة متعمقة[عدل]
- Lasserre C، Christa L، Simon MT، وآخرون. (1992). "A novel gene (HIP) activated in human primary liver cancer". Cancer Res. 52 (18): 5089–95. PMID 1325291.
- Orelle B، Keim V، Masciotra L، وآخرون. (1993). "Human pancreatitis-associated protein. Messenger RNA cloning and expression in pancreatic diseases". J. Clin. Invest. 90 (6): 2284–91. PMC 443380
. PMID 1469087. doi:10.1172/JCI116115.
- Itoh T، Teraoka H (1993). "Cloning and tissue-specific expression of cDNAs for the human and mouse homologues of rat pancreatitis-associated protein (PAP)". Biochim. Biophys. Acta. 1172 (1–2): 184–6. PMID 7679928. doi:10.1016/0167-4781(93)90290-t.
- Itoh T، Sawabu N، Motoo Y، وآخرون. (1995). "The human pancreatitis-associated protein (PAP)-encoding gene generates multiple transcripts through alternative use of 5' exons". Gene. 155 (2): 283–7. PMID 7721106. doi:10.1016/0378-1119(94)00799-X.
- Lasserre C، Simon MT، Ishikawa H، وآخرون. (1994). "Structural organization and chromosomal localization of a human gene (HIP/PAP) encoding a C-type lectin overexpressed in primary liver cancer". Eur. J. Biochem. 224 (1): 29–38. PMID 8076648. doi:10.1111/j.1432-1033.1994.tb19991.x.
- Christa L، Carnot F، Simon MT، وآخرون. (1997). "HIP/PAP is an adhesive protein expressed in hepatocarcinoma, normal Paneth, and pancreatic cells". Am. J. Physiol. 271 (6 Pt 1): G993–1002. PMID 8997243.
- Rafaeloff R، Pittenger GL، Barlow SW، وآخرون. (1997). "Cloning and sequencing of the pancreatic islet neogenesis associated protein (INGAP) gene and its expression in islet neogenesis in hamsters". J. Clin. Invest. 99 (9): 2100–9. PMC 508040
. PMID 9151782. doi:10.1172/JCI119383.
- Bödeker H، Keim V، Fiedler F، وآخرون. (2000). "PAP I interacts with itself, PAP II, PAP III, and lithostathine/regIalpha". Mol. Cell Biol. Res. Commun. 2 (3): 150–4. PMID 10662590. doi:10.1006/mcbr.1999.0166.
- Graf R، Schiesser M، Scheele GA، وآخرون. (2001). "A family of 16-kDa pancreatic secretory stress proteins form highly organized fibrillar structures upon tryptic activation". J. Biol. Chem. 276 (24): 21028–38. PMID 11278730. doi:10.1074/jbc.M010717200.
- Strausberg RL، Feingold EA، Grouse LH، وآخرون. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241
. PMID 12477932. doi:10.1073/pnas.242603899.
- Simon MT، Pauloin A، Normand G، وآخرون. (2003). "HIP/PAP stimulates liver regeneration after partial hepatectomy and combines mitogenic and anti-apoptotic functions through the PKA signaling pathway". FASEB J. 17 (11): 1441–50. PMID 12890698. doi:10.1096/fj.02-1013com.
- Gerhard DS، Wagner L، Feingold EA، وآخرون. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. PMC 528928
. PMID 15489334. doi:10.1101/gr.2596504.
- Lieu HT، Batteux F، Simon MT، وآخرون. (2005). "HIP/PAP accelerates liver regeneration and protects against acetaminophen injury in mice". Hepatology. 42 (3): 618–26. PMID 16116631. doi:10.1002/hep.20845.
- Rual JF، Venkatesan K، Hao T، وآخرون. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. PMID 16189514. doi:10.1038/nature04209.
- Cash HL، Whitham CV، Behrendt CL، Hooper LV (2006). "Symbiotic Bacteria Direct Expression of an Intestinal Bactericidal Lectin". Science. 313 (5790): 1126–30. PMC 2716667
. PMID 16931762. doi:10.1126/science.1127119.
- Ho MR، Lou YC، Lin WC، وآخرون. (2006). "Human pancreatitis-associated protein forms fibrillar aggregates with a native-like conformation". J. Biol. Chem. 281 (44): 33566–76. PMID 16963458. doi:10.1074/jbc.M604513200.
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