PRKRA
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هذا القسم فارغ أو غير مكتمل، ساهم بتحريره.
هذا القسم فارغ أو غير مكتمل، ساهم بتحريره.
PRKRA (Protein activator of interferon induced protein kinase EIF2AK2) هوَ بروتين يُشَفر بواسطة جين PRKRA في الإنسان.[1][1][2][3][4][5]
الوظيفة[عدل]

الأهمية السريرية[عدل]

المراجع[عدل]
- ↑ أ ب Patel RC, Sen GC (August 1998). "PACT, a protein activator of the interferon-induced protein kinase, PKR". EMBO J. 17 (15): 4379–90. doi:10.1093/emboj/17.15.4379. PMC 1170771. PMID 9687506. الوسيط
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تم تجاهله (مساعدة) - ^ Camargos S, Scholz S, Simón-Sánchez J, Paisán-Ruiz C, Lewis P, Hernandez D, Ding J, Gibbs JR, Cookson MR, Bras J, Guerreiro R, Oliveira CR, Lees A, Hardy J, Cardoso F, Singleton AB (March 2008). "DYT16, a novel young-onset dystonia-parkinsonism disorder: identification of a segregating mutation in the stress-response protein PRKRA". Lancet Neurology. 7 (3): 207–215. doi:10.1016/S1474-4422(08)70022-X. PMID 18243799. الوسيط
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تم تجاهله (مساعدة) - ^ Huang X, Hutchins B, Patel RC (August 2002). "The C-terminal, third conserved motif of the protein activator PACT plays an essential role in the activation of double-stranded-RNA-dependent protein kinase (PKR)". Biochem. J. 366 (Pt 1): 175–86. doi:10.1042/BJ20020204. PMC 1222748. PMID 11985496. الوسيط
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تم تجاهله (مساعدة) - ^ Ito T, Yang M, May WS (May 1999). "RAX, a cellular activator for double-stranded RNA-dependent protein kinase during stress signaling". J. Biol. Chem. 274 (22): 15427–32. doi:10.1074/jbc.274.22.15427. PMID 10336432. الوسيط
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تم تجاهله (مساعدة) - ^ "Entrez Gene: PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator". مؤرشف من الأصل في 05 ديسمبر 2010. الوسيط
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تم تجاهله (مساعدة)
قراءة متعمقة[عدل]
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. الوسيط
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تم تجاهله (مساعدة) - Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. الوسيط
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تم تجاهله (مساعدة) - Peters GA, Hartmann R, Qin J, et al. (2001). "Modular structure of PACT: distinct domains for binding and activating PKR". Mol Cell Biol. 21 (6): 1908–20. doi:10.1128/MCB.21.6.1908-1920.2001. PMC 86773. PMID 11238927. الوسيط
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تم تجاهله (مساعدة) - Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166. الوسيط
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تم تجاهله (مساعدة) - Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614. الوسيط
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تم تجاهله (مساعدة) - Horng T, Barton GM, Medzhitov R (2001). "TIRAP: an adapter molecule in the Toll signaling pathway". Nat. Immunol. 2 (9): 835–41. doi:10.1038/ni0901-835. PMID 11526399. الوسيط
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تم تجاهله (مساعدة) - Huang X, Hutchins B, Patel RC (2002). "The C-terminal, third conserved motif of the protein activator PACT plays an essential role in the activation of double-stranded-RNA-dependent protein kinase (PKR)". Biochem. J. 366 (Pt 1): 175–86. doi:10.1042/BJ20020204. PMC 1222748. PMID 11985496. الوسيط
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تم تجاهله (مساعدة) - Peters GA, Khoo D, Mohr I, Sen GC (2002). "Inhibition of PACT-mediated activation of PKR by the herpes simplex virus type 1 Us11 protein". J. Virol. 76 (21): 11054–64. doi:10.1128/JVI.76.21.11054-11064.2002. PMC 136652. PMID 12368348. الوسيط
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تم تجاهله (مساعدة) - Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. الوسيط
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تم تجاهله (مساعدة) - Yang M, Ito T, May WS (2003). "A novel role for RAX, the cellular activator of PKR, in synergistically stimulating SV40 large T antigen-dependent gene expression". J. Biol. Chem. 278 (40): 38325–32. doi:10.1074/jbc.M303420200. PMID 12874289. الوسيط
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تم تجاهله (مساعدة) - Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. الوسيط
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تم تجاهله (مساعدة) - Bennett RL, Blalock WL, May WS (2004). "Serine 18 phosphorylation of RAX, the PKR activator, is required for PKR activation and consequent translation inhibition". J. Biol. Chem. 279 (41): 42687–93. doi:10.1074/jbc.M403321200. PMID 15299031. الوسيط
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تم تجاهله (مساعدة) - Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. الوسيط
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تم تجاهله (مساعدة) - Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621. الوسيط
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تم تجاهله (مساعدة) - Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070. الوسيط
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تم تجاهله (مساعدة) - Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. الوسيط
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تم تجاهله (مساعدة) - Peters GA, Li S, Sen GC (2006). "Phosphorylation of specific serine residues in the PKR-activation domain of PACT is essential for its ability to mediate apoptosis". J Biol Chem. 281 (46): 35129–36. doi:10.1074/jbc.M607714200. PMID 16982605. الوسيط
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تم تجاهله (مساعدة) - Rowe TM, Rizzi M, Hirose K, Peters GA, et al. (2006). "A role of the double-stranded RNA-binding protein PACT in mouse ear development and hearing". Proc Natl Acad Sci USA. 103 (15): 5823–8. doi:10.1073/pnas.0601287103. PMC 1458657. PMID 16571658. الوسيط
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تم تجاهله (مساعدة) - Li S, Peters GA, Ding K, et al. (2006). "Molecular basis for PKR activation by PACT or dsRNA". Proc Natl Acad Sci USA. 103 (26): 10005–10. doi:10.1073/pnas.0602317103. PMC 1502496. PMID 16785445. الوسيط
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تم تجاهله (مساعدة) - Lee Y, Hur I, Park SY, et al. (2006). "The role of PACT in the RNA silencing pathway". EMBO J. 25 (3): 522–32. doi:10.1038/sj.emboj.7600942. PMC 1383527. PMID 16424907. الوسيط
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تم تجاهله (مساعدة) - Bennett RL, Blalock WL, Abtahi DM, et al. (2006). "RAX, the PKR activator, sensitizes cells to inflammatory cytokines, serum withdrawal, chemotherapy, and viral infection". Blood. 108 (3): 821–9. doi:10.1182/blood-2005-11-006817. PMC 1617065. PMID 16861340. الوسيط
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تم تجاهله (مساعدة) - Peters GA, Seachrist DD, Keri RA, et al. (2009). "The double-stranded RNA-binding protein, PACT, is required for postnatal anterior pituitary proliferation". Proc Natl Acad Sci USA. 106 (26): 10696–701. doi:10.1073/pnas.0900735106. PMC 2705576. PMID 19541653. الوسيط
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