DCTN1
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هذا القسم فارغ أو غير مكتمل، ساهم بتحريره.
هذا القسم فارغ أو غير مكتمل، ساهم بتحريره.
DCTN1 (Dynactin subunit 1) هوَ بروتين يُشَفر بواسطة جين DCTN1 في الإنسان.[1]
الوظيفة[عدل]

الأهمية السريرية[عدل]

المراجع[عدل]
- ^ Holzbaur EL، Hammarback JA، Paschal BM، Kravit NG، Pfister KK، Vallee RB (June 1991). "Homology of a 150K cytoplasmic dynein-associated polypeptide with the Drosophila gene Glued". Nature. 351 (6327): 579–83. PMID 1828535. doi:10.1038/351579a0.
قراءة متعمقة[عدل]
- Waterman-Storer CM، Karki S، Holzbaur EL (February 1995). "The p150Glued component of the dynactin complex binds to both microtubules and the actin-related protein centractin (Arp-1)". Proceedings of the National Academy of Sciences of the United States of America. 92 (5): 1634–8. PMC 42574
. PMID 7878030. doi:10.1073/pnas.92.5.1634.
- Paschal BM، Holzbaur EL، Pfister KK، Clark S، Meyer DI، Vallee RB (July 1993). "Characterization of a 50-kDa polypeptide in cytoplasmic dynein preparations reveals a complex with p150GLUED and a novel actin". The Journal of Biological Chemistry. 268 (20): 15318–23. PMID 8325901.
- Vaughan KT، Vallee RB (December 1995). "Cytoplasmic dynein binds dynactin through a direct interaction between the intermediate chains and p150Glued". The Journal of Cell Biology. 131 (6 Pt 1): 1507–16. PMC 2120689
. PMID 8522607. doi:10.1083/jcb.131.6.1507.
- Holzbaur EL، Tokito MK (February 1996). "Localization of the DCTN1 gene encoding p150Glued to human chromosome 2p13 by fluorescence in situ hybridization". Genomics. 31 (3): 398–9. PMID 8838327. doi:10.1006/geno.1996.0068.
- Tokito MK، Howland DS، Lee VM، Holzbaur EL (August 1996). "Functionally distinct isoforms of dynactin are expressed in human neurons". Molecular Biology of the Cell. 7 (8): 1167–80. PMC 275970
. PMID 8856662. doi:10.1091/mbc.7.8.1167.
- Sahni M، Zhou XM، Bakiri L، Schlessinger J، Baron R، Levy JB (December 1996). "Identification of a novel 135-kDa Grb2-binding protein in osteoclasts". The Journal of Biological Chemistry. 271 (51): 33141–7. PMID 8955163. doi:10.1074/jbc.271.51.33141.
- Blangy A، Arnaud L، Nigg EA (August 1997). "Phosphorylation by p34cdc2 protein kinase regulates binding of the kinesin-related motor HsEg5 to the dynactin subunit p150". The Journal of Biological Chemistry. 272 (31): 19418–24. PMID 9235942. doi:10.1074/jbc.272.31.19418.
- Korthaus D، Wedemeyer N، Lengeling A، Ronsiek M، Jockusch H، Schmitt-John T (July 1997). "Integrated radiation hybrid map of human chromosome 2p13: possible involvement of dynactin in neuromuscular diseases". Genomics. 43 (2): 242–4. PMID 9244444. doi:10.1006/geno.1997.4789.
- Waterman-Storer CM، Karki SB، Kuznetsov SA، Tabb JS، Weiss DG، Langford GM، Holzbaur EL (October 1997). "The interaction between cytoplasmic dynein and dynactin is required for fast axonal transport". Proceedings of the National Academy of Sciences of the United States of America. 94 (22): 12180–5. PMC 23743
. PMID 9342383. doi:10.1073/pnas.94.22.12180.
- Engelender S، Sharp AH، Colomer V، Tokito MK، Lanahan A، Worley P، Holzbaur EL، Ross CA (December 1997). "Huntingtin-associated protein 1 (HAP1) interacts with the p150Glued subunit of dynactin". Human Molecular Genetics. 6 (13): 2205–12. PMID 9361024. doi:10.1093/hmg/6.13.2205.
- Li SH، Gutekunst CA، Hersch SM، Li XJ (February 1998). "Interaction of huntingtin-associated protein with dynactin P150Glued". The Journal of Neuroscience. 18 (4): 1261–9. PMID 9454836.
- Karki S، LaMonte B، Holzbaur EL (August 1998). "Characterization of the p22 subunit of dynactin reveals the localization of cytoplasmic dynein and dynactin to the midbody of dividing cells". The Journal of Cell Biology. 142 (4): 1023–34. PMC 2132867
. PMID 9722614. doi:10.1083/jcb.142.4.1023.
- Collin GB، Nishina PM، Marshall JD، Naggert JK (November 1998). "Human DCTN1: genomic structure and evaluation as a candidate for Alström syndrome". Genomics. 53 (3): 359–64. PMID 9799602. doi:10.1006/geno.1998.5542.
- Tokito MK، Holzbaur EL (November 1998). "The genomic structure of DCTN1, a candidate gene for limb-girdle muscular dystrophy (LGMD2B)". Biochimica et Biophysica Acta. 1442 (2-3): 432–6. PMID 9805007. doi:10.1016/S0167-4781(98)00195-X.
- Bingham JB، Schroer TA (February 1999). "Self-regulated polymerization of the actin-related protein Arp1". Current Biology. 9 (4): 223–6. PMID 10074429. doi:10.1016/S0960-9822(99)80095-5.
- Heimann K، Percival JM، Weinberger R، Gunning P، Stow JL (April 1999). "Specific isoforms of actin-binding proteins on distinct populations of Golgi-derived vesicles". The Journal of Biological Chemistry. 274 (16): 10743–50. PMID 10196146. doi:10.1074/jbc.274.16.10743.
- Eckley DM، Gill SR، Melkonian KA، Bingham JB، Goodson HV، Heuser JE، Schroer TA (October 1999). "Analysis of dynactin subcomplexes reveals a novel actin-related protein associated with the arp1 minifilament pointed end". The Journal of Cell Biology. 147 (2): 307–20. PMC 2174220
. PMID 10525537. doi:10.1083/jcb.147.2.307.
- Karki S، Tokito MK، Holzbaur EL (February 2000). "A dynactin subunit with a highly conserved cysteine-rich motif interacts directly with Arp1". The Journal of Biological Chemistry. 275 (7): 4834–9. PMID 10671518. doi:10.1074/jbc.275.7.4834.
- Vancoillie G، Lambert J، Haeghen YV، Westbroek W، Mulder A، Koerten HK، Mommaas AM، Van Oostveldt P، Naeyaert JM (December 2000). "Colocalization of dynactin subunits P150Glued and P50 with melanosomes in normal human melanocytes". Pigment Cell Research. 13 (6): 449–57. PMID 11153697. doi:10.1034/j.1600-0749.2000.130607.x.
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