SERPINE2

SERPINE2
التراكيب المتوفرة بنك بيانات البروتين Ortholog search: PDBe RCSB قائمة رموز معرفات بنك بيانات البروتين 4DY0, 4DY7
المعرفات
الأسماء المستعارة	SERPINE2, GDN, GDNPF, PI-7, PI7, PN-1, PN1, PNI, serpin family E member 2
معرفات خارجية	الوراثة المندلية البشرية عبر الإنترنت 177010 MGI: MGI:101780 HomoloGene: 21247 GeneCards: 5270
علم الوجود الجيني الوظيفة الجزيئية • ‏GO:0001948 ربط بروتيني • glycosaminoglycan binding • peptidase inhibitor activity • heparin binding • serine-type endopeptidase inhibitor activity • receptor binding المكونات الخلوية • extracellular vesicle • extrinsic component of external side of plasma membrane • platelet alpha granule • نسيج خارج الخلية • عصارة خلوية • موصل عصبي عضلي • منطقة خارج الخلية • خارج خلوي • collagen-containing extracellular matrix العمليات الحيوية • negative regulation of phosphatidylinositol 3-kinase signaling • negative regulation of cell growth • seminal vesicle epithelium development • secretory granule organization • تعصب • mating plug formation • نماء عصبي • detection of mechanical stimulus involved in sensory perception • نمو متعدد الخلايا • regulation of cell migration • long-term synaptic potentiation • regulation of timing of cell differentiation • تمايز خلوي • negative regulation of proteolysis • negative regulation of protein catabolic process • negative regulation of plasminogen activation • cerebellar granular layer morphogenesis • negative regulation of cell proliferation • secretion by cell • negative regulation of sodium ion transport • negative regulation of smoothened signaling pathway • negative regulation of protein processing • positive regulation of astrocyte differentiation • negative regulation of platelet activation • response to wounding • regulation of synaptic transmission, glutamatergic • negative regulation of peptidase activity • negative regulation of blood coagulation • تجلط الدم • negative regulation of platelet aggregation • negative regulation of endopeptidase activity المصادر:Amigo / QuickGO
نمط التعبير عن الحمض النووي الريبوزي
المزيد من بيانات التعبير المرجعية
أورثولوج
الأنواع	الإنسان	الفأر
أنتريه	5270	20720
Ensembl	ENSG00000135919	ENSMUSG00000026249
يونيبروت	P07093 C9K031	Q07235
RefSeq (مرسال ر.ن.ا.)	‏NM_001136530، ‏NM_006216، ‏NR_073116، ‏XM_005246641، ‏XM_017004330، ‏XM_017004332 NM_001136528، ‏NM_001136530، ‏NM_006216، ‏NR_073116، ‏XM_005246641، ‏XM_017004330، ‏XM_017004332	‏XM_006496459 NM_009255، ‏XM_006496459
RefSeq (بروتين)	‏NP_001130002، ‏NP_006207، ‏XP_005246698، ‏XP_016859819، ‏XP_016859821 NP_001130000، ‏NP_001130002، ‏NP_006207، ‏XP_005246698، ‏XP_016859819، ‏XP_016859821	‏XP_006496522 NP_033281، ‏XP_006496522
الموقع (UCSC	n/a	Chr 1: 79.79 – 79.86 Mb
بحث ببمد	[1]	[2]
ويكي بيانات
اعرض/عدّل إنسان اعرض/عدّل فأر

SERPINE2‏ (Serpin family E member 2) هوَ بروتين يُشَفر بواسطة جين SERPINE2 في الإنسان.

الوظيفة

هذا القسم فارغ أو غير مكتمل، ساهم بتحريره.

الأهمية السريرية

هذا القسم فارغ أو غير مكتمل، ساهم بتحريره.

قراءة متعمقة

• Naldini L, Tamagnone L, Vigna E, et al. (1993). "Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor/scatter factor". EMBO J. 11 (13): 4825–33. PMC 556958. PMID 1334458.
• Gloor S, Odink K, Guenther J, et al. (1987). "A glia-derived neurite promoting factor with protease inhibitory activity belongs to the protease nexins". Cell. 47 (5): 687–93. doi:10.1016/0092-8674(86)90511-8. PMID 2877744.
• Sommer J, Gloor SM, Rovelli GF, et al. (1988). "cDNA sequence coding for a rat glia-derived nexin and its homology to members of the serpin superfamily". Biochemistry. 26 (20): 6407–10. doi:10.1021/bi00394a016. PMID 3427015.
• Scott RW, Bergman BL, Bajpai A, et al. (1985). "Protease nexin. Properties and a modified purification procedure". J. Biol. Chem. 260 (11): 7029–34. PMID 3997857.
• Magnaldo T, Bernerd F, Darmon M (1995). "Galectin-7, a human 14-kDa S-lectin, specifically expressed in keratinocytes and sensitive to retinoic acid". Dev. Biol. 168 (2): 259–71. doi:10.1006/dbio.1995.1078. PMID 7729568.
• Donovan FM, Vaughan PJ, Cunningham DD (1994). "Regulation of protease nexin-1 target protease specificity by collagen type IV". J. Biol. Chem. 269 (25): 17199–205. PMID 8006028.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Nykjaer A, Conese M, Christensen EI, et al. (1997). "Recycling of the urokinase receptor upon internalization of the uPA:serpin complexes". EMBO J. 16 (10): 2610–20. doi:10.1093/emboj/16.10.2610. PMC 1169872. PMID 9184208.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Li Y, Lu YY (2002). "Applying a highly specific and reproducible cDNA RDA method to clone garlic up-regulated genes in human gastric cancer cells". World J. Gastroenterol. 8 (2): 213–6. PMID 11925594.
• Grabham PW, Monard D, Gallimore PH, Grand RJ (1991). "Modulation of Human Neurite Outgrowth by Serine Proteases: A Comparison of the Interaction of Thrombin and Prothrombin with Glia-Derived Nexin". The European Journal of Neuroscience. 3 (7): 663–668. doi:10.1111/j.1460-9568.1991.tb00852.x. PMID 12106474.
• Crisp RJ, Knauer MF, Knauer DJ (2003). "Protease nexin 1 is a potent urinary plasminogen activator inhibitor in the presence of collagen type IV". J. Biol. Chem. 277 (49): 47285–91. doi:10.1074/jbc.M204813200. PMID 12356769.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Petrovic D, Milanez T, Kobal J, et al. (2003). "Prothrombotic gene polymorphisms and atherothrombotic cerebral infarction". Acta Neurol. Scand. 108 (2): 109–13. doi:10.1034/j.1600-0404.2003.00126.x. PMID 12859287.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kim JA, Tran ND, Li Z, et al. (2006). "Brain endothelial hemostasis regulation by pericytes". J. Cereb. Blood Flow Metab. 26 (2): 209–17. doi:10.1038/sj.jcbfm.9600181. PMID 16015279.
• Navaneetham D, Jin L, Pandey P, et al. (2006). "Structural and mutational analyses of the molecular interactions between the catalytic domain of factor XIa and the Kunitz protease inhibitor domain of protease nexin 2". J. Biol. Chem. 280 (43): 36165–75. doi:10.1074/jbc.M504990200. PMID 16085935.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

هذه بذرة مقالة عن جين على كروموسوم 2 بحاجة للتوسيع. شارك في تحريرها.