FCGR2A

Fc fragment of IgG receptor IIa
المعرفات
الأسماء المستعارة	Fc-gamma RII-a, low affinity immunoglobulin gamma Fc region receptor II-a, Fc gamma receptor RIIa3, FCGR2A, igG Fc receptor II-a, fcRII-a, Immunoglobulin G Fc receptor II, fc-gamma-RIIa, CDw32, Fc fragment of IgG, low affinity IIa, receptor (CD32)
معرفات خارجية
أورثولوج
	n/a
	n/a
	n/a
	n/a
	n/a
	n/a
	ويكي بيانات
اعرض/عدّل إنسان

FCGR2A‏ (Fc fragment of IgG receptor IIa) هوَ بروتين يُشَفر بواسطة جين FCGR2A في الإنسان.^[1]^[2]

الوظيفة[عدل]

الأهمية السريرية[عدل]

المراجع[عدل]

^ "Entrez Gene: FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)". مؤرشف من الأصل في 2009-05-10.
^ Qiu WQ، de Bruin D، Brownstein BH، Pearse R، Ravetch JV (يونيو 1990). "Organization of the human and mouse low-affinity Fc gamma R genes: duplication and recombination". Science. ج. 248 ع. 4956: 732–5. Bibcode:1990Sci...248..732Q. DOI:10.1126/science.2139735. PMID:2139735.

قراءة متعمقة[عدل]

McKenzie SE (2002). "Humanized mouse models of FcR clearance in immune platelet disorders". Blood Rev. ج. 16 ع. 1: 3–5. DOI:10.1054/blre.2001.0170. PMID:11913983.
Ernst LK، van de Winkel JG، Chiu IM، Anderson CL (1992). "Three genes for the human high affinity Fc receptor for IgG (Fc gamma RI) encode four distinct transcription products". J. Biol. Chem. ج. 267 ع. 22: 15692–700. PMID:1379234.
Seki T (1989). "Identification of multiple isoforms of the low-affinity human IgG Fc receptor". Immunogenetics. ج. 30 ع. 1: 5–12. DOI:10.1007/BF02421463. PMID:2526077.
Hessian PA، Highton J، Palmer DG (1989). "Quantification of macrophage cell surface molecules in rheumatoid arthritis". Clin. Exp. Immunol. ج. 77 ع. 1: 47–51. PMC:1541930. PMID:2527651.
Brooks DG، Qiu WQ، Luster AD، Ravetch JV (1989). "Structure and expression of human IgG FcRII(CD32). Functional heterogeneity is encoded by the alternatively spliced products of multiple genes". J. Exp. Med. ج. 170 ع. 4: 1369–85. DOI:10.1084/jem.170.4.1369. PMC:2189488. PMID:2529342.
Lanier LL، Cwirla S، Yu G، وآخرون (1990). "Membrane anchoring of a human IgG Fc receptor (CD16) determined by a single amino acid". Science. ج. 246 ع. 4937: 1611–3. Bibcode:1989Sci...246.1611L. DOI:10.1126/science.2531919. PMID:2531919.
Stuart SG، Trounstine ML، Vaux DJ، وآخرون (1987). "Isolation and expression of cDNA clones encoding a human receptor for IgG (Fc gamma RII)". J. Exp. Med. ج. 166 ع. 6: 1668–84. DOI:10.1084/jem.166.6.1668. PMC:2188792. PMID:2824655.
Hibbs ML، Bonadonna L، Scott BM، وآخرون (1988). "Molecular cloning of a human immunoglobulin G Fc receptor". Proc. Natl. Acad. Sci. U.S.A. ج. 85 ع. 7: 2240–4. Bibcode:1988PNAS...85.2240H. DOI:10.1073/pnas.85.7.2240. PMC:279966. PMID:2965389.
Huizinga TW، van der Schoot CE، Jost C، وآخرون (1988). "The PI-linked receptor FcRIII is released on stimulation of neutrophils". Nature. ج. 333 ع. 6174: 667–9. Bibcode:1988Natur.333..667H. DOI:10.1038/333667a0. PMID:2967437.
Sammartino L، Webber LM، Hogarth PM، وآخرون (1988). "Assignment of the gene coding for human FcRII (CD32) to bands q23q24 on chromosome 1". Immunogenetics. ج. 28 ع. 5: 380–1. DOI:10.1007/BF00364238. PMID:2971615.
Stengelin S، Stamenkovic I، Seed B (1988). "Isolation of cDNAs for two distinct human Fc receptors by ligand affinity cloning". EMBO J. ج. 7 ع. 4: 1053–9. PMC:454434. PMID:3402431.
Maruyama K، Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. ج. 138 ع. 1–2: 171–4. DOI:10.1016/0378-1119(94)90802-8. PMID:8125298.
Chacko GW، Brandt JT، Coggeshall KM، Anderson CL (1996). "Phosphoinositide 3-kinase and p72syk noncovalently associate with the low affinity Fc gamma receptor on human platelets through an immunoreceptor tyrosine-based activation motif. Reconstitution with synthetic phosphopeptides". J. Biol. Chem. ج. 271 ع. 18: 10775–81. DOI:10.1074/jbc.271.18.10775. PMID:8631888.
Salmon JE، Millard S، Schachter LA، وآخرون (1996). "Fc gamma RIIA alleles are heritable risk factors for lupus nephritis in African Americans". J. Clin. Invest. ج. 97 ع. 5: 1348–54. DOI:10.1172/JCI118552. PMC:507190. PMID:8636449.
Bewarder N، Weinrich V، Budde P، وآخرون (1996). "In vivo and in vitro specificity of protein tyrosine kinases for immunoglobulin G receptor (FcgammaRII) phosphorylation". Mol. Cell. Biol. ج. 16 ع. 9: 4735–43. PMC:231474. PMID:8756631.
Sármay G، Koncz G، Gergely J (1997). "Human type II Fcgamma receptors inhibit B cell activation by interacting with the p21(ras)-dependent pathway". J. Biol. Chem. ج. 271 ع. 48: 30499–504. DOI:10.1074/jbc.271.48.30499. PMID:8940017.
Ibarrola I، Vossebeld PJ، Homburg CH، وآخرون (1997). "Influence of tyrosine phosphorylation on protein interaction with FcgammaRIIa". Biochim. Biophys. Acta. ج. 1357 ع. 3: 348–58. DOI:10.1016/S0167-4889(97)00034-7. PMID:9268059.
Suzuki Y، Yoshitomo-Nakagawa K، Maruyama K، وآخرون (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. ج. 200 ع. 1–2: 149–56. DOI:10.1016/S0378-1119(97)00411-3. PMID:9373149.
De SK، Venkateshan CN، Seth P، وآخرون (1998). "Adenovirus-mediated human immunodeficiency virus-1 Nef expression in human monocytes/macrophages and effect of Nef on downmodulation of Fcgamma receptors and expression of monokines". Blood. ج. 91 ع. 6: 2108–17. PMID:9490697.

هذه بذرة مقالة عن جين على كروموسوم 1 بحاجة للتوسيع. فضلًا شارك في تحريرها.

[1] "Entrez Gene: FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)". مؤرشف من الأصل في 2009-05-10.

[pmid2139735-2] Qiu WQ، de Bruin D، Brownstein BH، Pearse R، Ravetch JV (يونيو 1990). "Organization of the human and mouse low-affinity Fc gamma R genes: duplication and recombination". Science. ج. 248 ع. 4956: 732–5. Bibcode:1990Sci...248..732Q. DOI:10.1126/science.2139735. PMID:2139735.

[1]

[2]