ANGPTL3

ANGPTL3
المعرفات
الأسماء المستعارة	ANGPTL3, ANG-5, ANGPT5, ANL3, FHBL2, angiopoietin like 3
معرفات خارجية	الوراثة المندلية البشرية عبر الإنترنت 604774 MGI: MGI:1353627 HomoloGene: 8499 GeneCards: 27329
علم الوجود الجيني الوظيفة الجزيئية • phospholipase inhibitor activity • ‏GO:0048551 enzyme inhibitor activity • integrin binding • growth factor activity • heparin binding المكونات الخلوية • جهاز غولجي • cell surface • early endosome • إسقاط خلية • lamellipodium • منطقة خارج الخلية • خارج خلوي العمليات الحيوية • phospholipid homeostasis • positive regulation of cell migration • positive regulation of lipid catabolic process • lipid storage • cholesterol metabolic process • أيض الحموض الدهنية • positive regulation of angiogenesis • artery morphogenesis • lipid homeostasis • phospholipid catabolic process • integrin-mediated signaling pathway • negative regulation of lipoprotein lipase activity • response to hormone • phospholipid metabolic process • cholesterol homeostasis • acylglycerol homeostasis • cell-matrix adhesion • glycerol metabolic process • negative regulation of phospholipase activity • triglyceride homeostasis • ‏GO:0072468 توصيل الإشارة • أيض الليبيدات • التصاق الخلايا • توليد الأوعية • regulation of lipoprotein lipase activity • regulation of signaling receptor activity المصادر:Amigo / QuickGO
نمط التعبير عن الحمض النووي الريبوزي
المزيد من بيانات التعبير المرجعية
أورثولوج
الأنواع	الإنسان	الفأر
أنتريه	27329	30924
Ensembl	ENSG00000132855	ENSMUSG00000028553
يونيبروت	Q9Y5C1	Q9R182
RefSeq (مرسال ر.ن.ا.)	NM_014495	NM_013913
RefSeq (بروتين)	NP_055310	NP_038941
الموقع (UCSC	n/a	Chr 4: 98.92 – 98.93 Mb
بحث ببمد	[1]	[2]
ويكي بيانات
اعرض/عدّل إنسان اعرض/عدّل فأر

ANGPTL3‏ (Angiopoietin like 3) هوَ بروتين يُشَفر بواسطة جين ANGPTL3 في الإنسان.

قراءة متعمقة

• "Probucol markedly reduces HDL phospholipids and elevated prebeta1-HDL without delayed conversion into alpha-migrating HDL: putative role of angiopoietin-like protein 3 in probucol-induced HDL remodeling". Atherosclerosis. 200 (2): 329–35. أكتوبر 2008. doi:10.1016/j.atherosclerosis.2007.12.031. PMID 18279878.
• "Higher frequency of abnormal serum angiopoietin-like protein 3 than abnormal cholesteryl ester transfer protein in Japanese hyperalphalipoproteinemic subjects". Clin. Chim. Acta. 398 (1–2): 99–104. ديسمبر 2008. doi:10.1016/j.cca.2008.08.021. PMID 18804459.
• Li C (2007). "Genetics and regulation of angiopoietin-like proteins 3 and 4". Curr. Opin. Lipidol. 17 (2): 152–6. doi:10.1097/01.mol.0000217896.67444.05. PMID 16531751.
• "ANGPTL3 stimulates endothelial cell adhesion and migration via integrin alpha vbeta 3 and induces blood vessel formation in vivo". J. Biol. Chem. 277 (19): 17281–90. 2002. doi:10.1074/jbc.M109768200. PMID 11877390.
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• "Regulation of the angiopoietin-like protein 3 gene by LXR". J. Lipid Res. 44 (1): 136–43. 2003. doi:10.1194/jlr.M200367-JLR200. PMID 12518032.
• "Angiopoietin-like protein 3, a hepatic secretory factor, activates lipolysis in adipocytes". Biochem. Biophys. Res. Commun. 301 (2): 604–9. 2003. doi:10.1016/S0006-291X(02)03058-9. PMID 12565906.
• "Identification of a novel human angiopoietin-like gene expressed mainly in heart". J. Hum. Genet. 48 (3): 159–62. 2003. doi:10.1007/s100380300025. PMID 12624729.
• "Protein region important for regulation of lipid metabolism in angiopoietin-like 3 (ANGPTL3): ANGPTL3 is cleaved and activated in vivo". J. Biol. Chem. 278 (43): 41804–9. 2004. doi:10.1074/jbc.M302861200. PMID 12909640.
• "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. 2003. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. 2005. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
• "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". J. Proteome Res. 4 (6): 2070–80. 2006. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
• "Angiopoietin-like protein3 regulates plasma HDL cholesterol through suppression of endothelial lipase". Arterioscler. Thromb. Vasc. Biol. 27 (2): 366–72. 2007. doi:10.1161/01.ATV.0000252827.51626.89. PMID 17110602.