ARF1

ARF1
التراكيب المتوفرة بنك بيانات البروتين Ortholog search: PDBe RCSB قائمة رموز معرفات بنك بيانات البروتين 1HUR, 1RE0, 1U81, 3O47, 4HMY, 1R8Q, 1RRG, 1RRF
المعرفات
الأسماء المستعارة	ARF1, ADP ribosylation factor 1, PVNH8
معرفات خارجية	الوراثة المندلية البشرية عبر الإنترنت 103180 MGI: MGI:99431 HomoloGene: 133930 GeneCards: 375
علم الوجود الجيني الوظيفة الجزيئية • phospholipase D activator activity • nucleotide binding • GTP binding • ربط أيون المغنسيوم • GTPase activity • GDP binding • ‏GO:0001948 ربط بروتيني • RNA binding • protein domain specific binding • protein heterodimerization activity المكونات الخلوية • extracellular exosome • late endosome • سيتوبلازم • تشابك عصبي • trans-Golgi network • جهاز غولجي • موصل خلوي • نظام غشائي داخلي • peroxisomal membrane • cell leading edge • إسقاط عصبون • ‏GO:0097483، ‏GO:0097481 كثافة بعد المشبكي • postsynaptic membrane • غشاء • focal adhesion • داخل خلوي • perinuclear region of cytoplasm • ساركومير • COPI-coated vesicle • عصارة خلوية • Golgi membrane • غشاء خلوي • macromolecular complex • glutamatergic synapse العمليات الحيوية • positive regulation of endocytosis • positive regulation of protein secretion • very-low-density lipoprotein particle assembly • regulation of defense response to virus by virus • positive regulation of calcium ion-dependent exocytosis • regulation of receptor internalization • synaptic vesicle budding • small GTPase mediated signal transduction • cellular copper ion homeostasis • long term synaptic depression • antigen processing and presentation of exogenous peptide antigen via MHC class II • Golgi to transport vesicle transport • post-Golgi vesicle-mediated transport • actin filament organization • lysosomal membrane organization • positive regulation of ER to Golgi vesicle-mediated transport • dendritic spine organization • regulation of phospholipid metabolic process • regulation of Arp2/3 complex-mediated actin nucleation • positive regulation of late endosome to lysosome transport • protein transport • phosphatidylinositol biosynthetic process • positive regulation of sodium ion transmembrane transport • vesicle-mediated transport • ‏GO:0048554 positive regulation of catalytic activity • positive regulation of dendritic spine development • mitotic cleavage furrow ingression • interleukin-12-mediated signaling pathway • نقل • intracellular protein transport • Golgi to plasma membrane transport • postsynaptic actin cytoskeleton organization المصادر:Amigo / QuickGO
نمط التعبير عن الحمض النووي الريبوزي
المزيد من بيانات التعبير المرجعية
أورثولوج
الأنواع	الإنسان	الفأر
أنتريه	375	11840
Ensembl	ENSG00000143761	ENSMUSG00000048076
يونيبروت	P84077	P84078
RefSeq (مرسال ر.ن.ا.)	‏NM_001024226، ‏NM_001024227، ‏NM_001024228، ‏XM_017001233 NM_001658، ‏NM_001024226، ‏NM_001024227، ‏NM_001024228، ‏XM_017001233	‏NM_007476 NM_001130408، ‏NM_007476
RefSeq (بروتين)	‏NP_001019398، ‏NP_001019399، ‏NP_001649، ‏XP_016856722 NP_001019397، ‏NP_001019398، ‏NP_001019399، ‏NP_001649، ‏XP_016856722	‏NP_031502 NP_001123880، ‏NP_031502
الموقع (UCSC	n/a	Chr 11: 59.21 – 59.23 Mb
بحث ببمد	[1]	[2]
ويكي بيانات
اعرض/عدّل إنسان اعرض/عدّل فأر

ARF1‏ (ADP ribosylation factor 1) هوَ بروتين يُشَفر بواسطة جين ARF1 في الإنسان.

الوظيفة

هذا القسم فارغ أو غير مكتمل، ساهم بتحريره.

الأهمية السريرية

هذا القسم فارغ أو غير مكتمل، ساهم بتحريره.

قراءة متعمقة

• Serafini T, Orci L, Amherdt M, et al. (1991). "ADP-ribosylation factor is a subunit of the coat of Golgi-derived COP-coated vesicles: a novel role for a GTP-binding protein". Cell. 67 (2): 239–53. doi:10.1016/0092-8674(91)90176-Y. PMID 1680566.
• Kahn RA, Kern FG, Clark J, et al. (1991). "Human ADP-ribosylation factors. A functionally conserved family of GTP-binding proteins". J. Biol. Chem. 266 (4): 2606–14. PMID 1899243.
• Stearns T, Willingham MC, Botstein D, Kahn RA (1990). "ADP-ribosylation factor is functionally and physically associated with the Golgi complex". Proc. Natl. Acad. Sci. U.S.A. 87 (3): 1238–42. doi:10.1073/pnas.87.3.1238. PMC 53446. PMID 2105501.
• Bobak DA, Nightingale MS, Murtagh JJ, et al. (1989). "Molecular cloning, characterization, and expression of human ADP-ribosylation factors: two guanine nucleotide-dependent activators of cholera toxin". Proc. Natl. Acad. Sci. U.S.A. 86 (16): 6101–5. doi:10.1073/pnas.86.16.6101. PMC 297783. PMID 2474826.
• Greasley SE, Jhoti H, Teahan C, et al. (1995). "The structure of rat ADP-ribosylation factor-1 (ARF-1) complexed to GDP determined from two different crystal forms". Nat. Struct. Biol. 2 (9): 797–806. doi:10.1038/nsb0995-797. PMID 7552752.
• Welsh CF, Moss J, Vaughan M (1995). "ADP-ribosylation factors: a family of approximately 20-kDa guanine nucleotide-binding proteins that activate cholera toxin". Mol. Cell. Biochem. 138 (1–2): 157–66. doi:10.1007/BF00928458. PMID 7898460.
• Greasley S, Jhoti H, Fensome AC, et al. (1995). "Crystallization and preliminary X-ray diffraction studies on ADP-ribosylation factor 1". J. Mol. Biol. 244 (5): 651–3. doi:10.1006/jmbi.1994.1759. PMID 7990146.
• Amor JC, Harrison DH, Kahn RA, Ringe D (1994). "Structure of the human ADP-ribosylation factor 1 complexed with GDP". Nature. 372 (6507): 704–8. doi:10.1038/372704a0. PMID 7990966.
• Dascher C, Balch WE (1994). "Dominant inhibitory mutants of ARF1 block endoplasmic reticulum to Golgi transport and trigger disassembly of the Golgi apparatus". J. Biol. Chem. 269 (2): 1437–48. PMID 8288610.
• Rümenapp U, Geiszt M, Wahn F, et al. (1996). "Evidence for ADP-ribosylation-factor-mediated activation of phospholipase D by m3 muscarinic acetylcholine receptor". Eur. J. Biochem. 234 (1): 240–4. doi:10.1111/j.1432-1033.1995.240_c.x. PMID 8529647.
• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Hirai M, Kusuda J, Hashimoto K (1997). "Assignment of human ADP ribosylation factor (ARF) genes ARF1 and ARF3 to chromosomes 1q42 and 12q13, respectively". Genomics. 34 (2): 263–5. doi:10.1006/geno.1996.0283. PMID 8661066.
• Kanoh H, Williger BT, Exton JH (1997). "Arfaptin 1, a putative cytosolic target protein of ADP-ribosylation factor, is recruited to Golgi membranes". J. Biol. Chem. 272 (9): 5421–9. doi:10.1074/jbc.272.9.5421. PMID 9038142.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Shome K, Vasudevan C, Romero G (1997). "ARF proteins mediate insulin-dependent activation of phospholipase D". Curr. Biol. 7 (6): 387–96. doi:10.1016/S0960-9822(06)00186-2. PMID 9197239.
• Frank S, Upender S, Hansen SH, Casanova JE (1998). "ARNO is a guanine nucleotide exchange factor for ADP-ribosylation factor 6". J. Biol. Chem. 273 (1): 23–7. doi:10.1074/jbc.273.1.23. PMID 9417041.
• Betz SF, Schnuchel A, Wang H, et al. (1998). "Solution structure of the cytohesin-1 (B2-1) Sec7 domain and its interaction with the GTPase ADP ribosylation factor 1". Proc. Natl. Acad. Sci. U.S.A. 95 (14): 7909–14. doi:10.1073/pnas.95.14.7909. PMC 20903. PMID 9653114.
• Kim JH, Lee SD, Han JM, et al. (1998). "Activation of phospholipase D1 by direct interaction with ADP-ribosylation factor 1 and RalA". FEBS Lett. 430 (3): 231–5. doi:10.1016/S0014-5793(98)00661-9. PMID 9688545.
• Huber I, Cukierman E, Rotman M, et al. (1998). "Requirement for both the amino-terminal catalytic domain and a noncatalytic domain for in vivo activity of ADP-ribosylation factor GTPase-activating protein". J. Biol. Chem. 273 (38): 24786–91. doi:10.1074/jbc.273.38.24786. PMID 9733781.

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