CTNNBIP1

CTNNBIP1
التراكيب المتوفرة بنك بيانات البروتين Ortholog search: PDBe RCSB قائمة رموز معرفات بنك بيانات البروتين 1M1E, 1T08
المعرفات
الأسماء المستعارة	CTNNBIP1, ICAT, catenin beta interacting protein 1
معرفات خارجية	الوراثة المندلية البشرية عبر الإنترنت 607758 MGI: MGI:1915756 HomoloGene: 10641 GeneCards: 56998
علم الوجود الجيني الوظيفة الجزيئية • beta-catenin binding • ‏GO:0001948 ربط بروتيني • armadillo repeat domain binding المكونات الخلوية • سيتوبلازم • عصارة خلوية • بلازم نووي • نواة • beta-catenin destruction complex العمليات الحيوية • negative regulation of smooth muscle cell proliferation • negative regulation of protein-containing complex assembly • negative regulation of DNA binding • negative regulation of Wnt signaling pathway • regulation of vascular permeability involved in acute inflammatory response • negative regulation of transcription by RNA polymerase II • بروتين دبيلو.أن.تي • negative regulation of protein binding • negative regulation of DNA-binding transcription factor activity • branching involved in ureteric bud morphogenesis • positive regulation of osteoblast differentiation • positive regulation of monocyte differentiation • negative regulation of transcription initiation from RNA polymerase II promoter • negative regulation of mesenchymal cell proliferation • نقل شاردة الكالسيوم المصادر:Amigo / QuickGO
أورثولوج
الأنواع	الإنسان	الفأر
أنتريه	56998	67087
Ensembl	ENSG00000178585	ENSMUSG00000028988
يونيبروت	Q9NSA3	Q9JJN6
RefSeq (مرسال ر.ن.ا.)	‏NM_001012329، ‏XM_017001853، ‏XM_017001854، ‏XM_017001855 NM_020248، ‏NM_001012329، ‏XM_017001853، ‏XM_017001854، ‏XM_017001855	‏NM_023465 NM_001141930، ‏NM_023465
RefSeq (بروتين)	‏NP_064633، ‏XP_016857342، ‏XP_016857343، ‏XP_016857344 NP_001012329، ‏NP_064633، ‏XP_016857342، ‏XP_016857343، ‏XP_016857344	‏NP_075954 NP_001135402، ‏NP_075954
الموقع (UCSC	n/a	Chr 4: 149.52 – 149.57 Mb
بحث ببمد	[1]	[2]
ويكي بيانات
اعرض/عدّل إنسان اعرض/عدّل فأر

CTNNBIP1‏ (Catenin beta interacting protein 1) هوَ بروتين يُشَفر بواسطة جين CTNNBIP1 في الإنسان.

الوظيفة

هذا القسم فارغ أو غير مكتمل، ساهم بتحريره.

الأهمية السريرية

هذا القسم فارغ أو غير مكتمل، ساهم بتحريره.

قراءة متعمقة

• "A genome-wide screen for beta-catenin binding sites identifies a downstream enhancer element that controls c-Myc gene expression". Mol. Cell. Biol. 28 (24): 7368–79. 2008. doi:10.1128/MCB.00744-08. PMC 2593444. PMID 18852287.
• "IQ-domain GTPase-activating protein 1 regulates beta-catenin at membrane ruffles and its role in macropinocytosis of N-cadherin and adenomatous polyposis coli". J. Biol. Chem. 282 (11): 8545–56. 2007. doi:10.1074/jbc.M610272200. PMID 17255093.
• "Clinicopathological significance of expression of p-c-Jun, TCF4 and beta-Catenin in colorectal tumors". BMC Cancer. 8: 328. 2008. doi:10.1186/1471-2407-8-328. PMC 2585585. PMID 18992165.
• "ICAT as a potential enhancer of monocytic differentiation: implications from the comparative proteome analysis of the HL60 cell line stimulated by all-trans retinoic acid and NSC67657". Cell Biochem. Funct. 27 (6): 329–37. 2009. doi:10.1002/cbf.1576. PMID 19569129.
• "Comparative proteomics analysis on differentiation of human promyelocytic leukemia HL-60 cells into granulocyte and monocyte lineages". Ai Zheng. 28 (2): 117–21. 2009. PMID 19550115.
• "E-cadherin but not beta-catenin expression is decreased in laryngeal biopsies from patients with laryngopharyngeal reflux". Eur Arch Otorhinolaryngol. 265 (8): 937–42. 2008. doi:10.1007/s00405-007-0568-6. PMID 18183411.
• "Relation between cell-to-cell adhesion and angiogenesis and clinico-morphological prognostic factors in patients with gastric cancer". Exp. Oncol. 30 (3): 235–9. 2008. PMID 18806748.
• "Beta-catenin degradation mediated by the CID domain of APC provides a model for the selection of APC mutations in colorectal, desmoid and duodenal tumours". Hum. Mol. Genet. 18 (2): 213–26. 2009. doi:10.1093/hmg/ddn338. PMID 18854359.
• "Axin-independent phosphorylation of APC controls beta-catenin signaling via cytoplasmic retention of beta-catenin". Biochem. Biophys. Res. Commun. 357 (1): 81–6. 2007. doi:10.1016/j.bbrc.2007.03.117. PMID 17418091.
• "MicroRNA profiling in hepatocellular tumors is associated with clinical features and oncogene/tumor suppressor gene mutations". Hepatology. 47 (6): 1955–63. 2008. doi:10.1002/hep.22256. PMID 18433021.
• "Wnt pathway is involved in advanced gastric carcinoma". Hepatogastroenterology. 55 (84): 1126–30. 2008. PMID 18705344.
• "Identification of WNT/beta-CATENIN signaling pathway components in human cumulus cells". Mol. Hum. Reprod. 15 (1): 11–7. 2009. doi:10.1093/molehr/gan070. PMID 19038973.
• "Correlation between beta-catenin widespread nuclear expression and matrix metalloproteinase-7 overexpression in sporadic desmoid tumors". Hum. Pathol. 39 (12): 1802–8. 2008. doi:10.1016/j.humpath.2008.05.005. PMID 18715618.
• "Ph+/VE-cadherin+ identifies a stem cell like population of acute lymphoblastic leukemia sustained by bone marrow niche cells". Blood. 110 (9): 3334–44. 2007. doi:10.1182/blood-2007-01-068122. PMC 2200915. PMID 17638851.
• "Familial medulloblastoma: case report of one family and review of the literature". Neurosurgery. 51 (1): 227–33, discussion 233. 2002. doi:10.1097/00006123-200207000-00035. PMID 12182422.
• "HINT1 inhibits beta-catenin/TCF4, USF2 and NFkappaB activity in human hepatoma cells". Int. J. Cancer. 124 (7): 1526–34. 2009. doi:10.1002/ijc.24072. PMC 2667231. PMID 19089909.
• "Amyloid precursor protein modulates beta-catenin degradation". Journal of Neuroinflammation. 4: 29. 2007. doi:10.1186/1742-2094-4-29. PMC 2231348. PMID 18070361.
• "Somatic mutations of adenomatous polyposis coli gene and nuclear b-catenin accumulation have prognostic significance in invasive urothelial carcinomas: evidence for Wnt pathway implication". Int. J. Cancer. 124 (1): 103–8. 2009. doi:10.1002/ijc.23917. PMID 18844223.
• "Clinicopathological and molecular analysis of endometrial carcinoma associated with tamoxifen". Mod. Pathol. 21 (8): 925–36. 2008. doi:10.1038/modpathol.2008.49. PMID 18500270.
• "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. 2007. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

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