C1QA

C1QA
التراكيب المتوفرة بنك بيانات البروتين Ortholog search: PDBe RCSB قائمة رموز معرفات بنك بيانات البروتين 1PK6, 2JG8, 2JG9, 2WNU, 2WNV, 5HZF, 5HKJ
المعرفات
الأسماء المستعارة	C1QA, complement C1q A chain
معرفات خارجية	الوراثة المندلية البشرية عبر الإنترنت 120550 MGI: MGI:88223 HomoloGene: 7249 GeneCards: 712
علم الوجود الجيني الوظيفة الجزيئية • ‏GO:0001948 ربط بروتيني • serine-type endopeptidase activity • amyloid-beta binding المكونات الخلوية • منطقة خارج الخلية • كولاجين • complement component C1 complex • collagen-containing extracellular matrix • تشابك عصبي • postsynapse • amyloid-beta complex العمليات الحيوية • immune system process • complement activation • cell-cell signaling • سبيل تقليدي متمم • response to iron ion • مناعة فطرية • تحلل بروتيني • regulation of complement activation • شيخوخة • neuron remodeling • synapse organization • positive regulation of astrocyte activation • synapse disassembly • complement-mediated synapse pruning • vertebrate eye-specific patterning • positive regulation of neuron death • positive regulation of microglial cell activation المصادر:Amigo / QuickGO
نمط التعبير عن الحمض النووي الريبوزي
المزيد من بيانات التعبير المرجعية
أورثولوج
الأنواع	الإنسان	الفأر
أنتريه	712	12259
Ensembl	ENSG00000173372	ENSMUSG00000036887
يونيبروت	P02745	P98086
RefSeq (مرسال ر.ن.ا.)	‏NM_001347465، ‏NM_001347466 NM_015991، ‏NM_001347465، ‏NM_001347466	NM_007572
RefSeq (بروتين)	‏NP_001334395، ‏NP_057075 NP_001334394، ‏NP_001334395، ‏NP_057075	NP_031598
الموقع (UCSC	n/a	Chr 4: 136.9 – 136.9 Mb
بحث ببمد	[1]	[2]
ويكي بيانات
اعرض/عدّل إنسان اعرض/عدّل فأر

C1QA‏ (Complement C1q A chain) هوَ بروتين يُشَفر بواسطة جين C1QA في الإنسان.

الوظيفة

هذا القسم فارغ أو غير مكتمل، ساهم بتحريره.

الأهمية السريرية

هذا القسم فارغ أو غير مكتمل، ساهم بتحريره.

قراءة متعمقة

• Petry F (1999). "Molecular basis of hereditary C1q deficiency". Immunobiology. 199 (2): 286–94. doi:10.1016/s0171-2985(98)80033-8. PMID 9777412.
• Thielens NM, Tacnet-Delorme P, Arlaud GJ (2003). "Interaction of C1q and mannan-binding lectin with viruses". Immunobiology. 205 (4–5): 563–74. doi:10.1078/0171-2985-00155. PMID 12396016.
• Reid KB (1976). "Isolation, by partial pepsin digestion, of the three collagen-like regions present in subcomponent Clq of the first component of human complement". Biochem. J. 155 (1): 5–17. PMC 1172796. PMID 7240.
• Reid KB (1979). "Complete amino acid sequences of the three collagen-like regions present in subcomponent C1q of the first component of human complement". Biochem. J. 179 (2): 367–71. PMC 1186634. PMID 486087.
• Krumdieck R, Höök M, Rosenberg LC, Volanakis JE (1992). "The proteoglycan decorin binds C1q and inhibits the activity of the C1 complex". J. Immunol. 149 (11): 3695–701. PMID 1431141.
• Sellar GC, Blake DJ, Reid KB (1991). "Characterization and organization of the genes encoding the A-, B- and C-chains of human complement subcomponent C1q. The complete derived amino acid sequence of human C1q". Biochem. J. 274 (2): 481–90. PMC 1150164. PMID 1706597.
• Ebenbichler CF, Thielens NM, Vornhagen R, et al. (1992). "Human immunodeficiency virus type 1 activates the classical pathway of complement by direct C1 binding through specific sites in the transmembrane glycoprotein gp41". J. Exp. Med. 174 (6): 1417–24. doi:10.1084/jem.174.6.1417. PMC 2119058. PMID 1744579.
• Su H, Boackle RJ (1991). "Interaction of the envelope glycoprotein of human immunodeficiency virus with C1q and fibronectin under conditions present in human saliva". Mol. Immunol. 28 (8): 811–7. doi:10.1016/0161-5890(91)90044-K. PMID 1875953.
• Busby TF, Ingham KC (1990). "NH2-terminal calcium-binding domain of human complement C1s- mediates the interaction of C1r- with C1q". Biochemistry. 29 (19): 4613–8. doi:10.1021/bi00471a016. PMID 2372546.
• Bing DH, Almeda S, Isliker H, et al. (1982). "Fibronectin binds to the C1q component of complement". Proc. Natl. Acad. Sci. U.S.A. 79 (13): 4198–201. doi:10.1073/pnas.79.13.4198. PMC 346605. PMID 6981115.
• Reid KB, Gagnon J, Frampton J (1982). "Completion of the amino acid sequences of the A and B chains of subcomponent C1q of the first component of human complement". Biochem. J. 203 (3): 559–69. PMC 1158269. PMID 6981411.
• Stoiber H, Thielens NM, Ebenbichler C, et al. (1994). "The envelope glycoprotein of HIV-1 gp120 and human complement protein C1q bind to the same peptides derived from three different regions of gp41, the transmembrane glycoprotein of HIV-1, and share antigenic homology". Eur. J. Immunol. 24 (2): 294–300. doi:10.1002/eji.1830240203. PMID 7507842.
• Prohászka Z, Hidvégi T, Ujhelyi E, et al. (1995). "Interaction of complement and specific antibodies with the external glycoprotein 120 of HIV-1". Immunology. 85 (2): 184–9. PMC 1383879. PMID 7642209.
• Stoiber H, Ebenbichler CF, Thielens NM, et al. (1995). "HIV-1 rsgp41 depends on calcium for binding of human c1q but not for binding of gp120". Mol. Immunol. 32 (5): 371–4. doi:10.1016/0161-5890(94)00156-U. PMID 7739575.
• Gulati P, Guc D, Lemercier C, et al. (1994). "Expression of the components and regulatory proteins of the classical pathway of complement in normal and diseased synovium". Rheumatol. Int. 14 (1): 13–9. doi:10.1007/BF00302666. PMID 7939135.
• Gulati P, Lemercier C, Guc D, et al. (1994). "Regulation of the synthesis of C1 subcomponents and C1-inhibitor". Behring Inst. Mitt. (93): 196–203. PMID 8172568.
• Ghebrehiwet B, Lim BL, Peerschke EI, et al. (1994). "Isolation, cDNA cloning, and overexpression of a 33-kD cell surface glycoprotein that binds to the globular "heads" of C1q". J. Exp. Med. 179 (6): 1809–21. doi:10.1084/jem.179.6.1809. PMC 2191527. PMID 8195709.
• Thielens NM, Bally IM, Ebenbichler CF, et al. (1994). "Further characterization of the interaction between the C1q subcomponent of human C1 and the transmembrane envelope glycoprotein gp41 of HIV-1". J. Immunol. 151 (11): 6583–92. PMID 8245486.
• Hidvégi T, Prohászka Z, Ujhelyi E, et al. (1994). "Studies on the mechanism of complement-mediated inhibition of antibody binding to HIV gp41". Clin. Exp. Immunol. 94 (3): 490–3. doi:10.1111/j.1365-2249.1993.tb08223.x. PMC 1534428. PMID 8252810.

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