C1QA

C1QA
التراكيب المتوفرة بنك بيانات البروتين Ortholog search: PDBe RCSB قائمة رموز معرفات بنك بيانات البروتين 1PK6, 2JG8, 2JG9, 2WNU, 2WNV, 5HZF, 5HKJ
المعرفات
الأسماء المستعارة	C1QA, complement C1q A chain
معرفات خارجية	الوراثة المندلية البشرية عبر الإنترنت 120550 MGI: MGI:88223 HomoloGene: 7249 GeneCards: 712
علم الوجود الجيني الوظيفة الجزيئية • ‏GO:0001948 ربط بروتيني • serine-type endopeptidase activity • amyloid-beta binding المكونات الخلوية • منطقة خارج الخلية • كولاجين • complement component C1 complex • collagen-containing extracellular matrix • تشابك عصبي • postsynapse • amyloid-beta complex العمليات الحيوية • immune system process • complement activation • cell-cell signaling • سبيل تقليدي متمم • response to iron ion • مناعة فطرية • تحلل بروتيني • regulation of complement activation • شيخوخة • neuron remodeling • synapse organization • positive regulation of astrocyte activation • synapse pruning • complement-mediated synapse pruning • vertebrate eye-specific patterning • positive regulation of neuron death • positive regulation of microglial cell activation المصادر:Amigo / QuickGO
نمط التعبير عن الحمض النووي الريبوزي
المزيد من بيانات التعبير المرجعية
أورثولوج
الأنواع	الإنسان	الفأر
أنتريه	712	12259
Ensembl	ENSG00000173372	ENSMUSG00000036887
يونيبروت	P02745	P98086
RefSeq (مرسال ر.ن.ا.)	‏NM_001347465، ‏NM_001347466 NM_015991، ‏NM_001347465، ‏NM_001347466	NM_007572
RefSeq (بروتين)	‏NP_001334395، ‏NP_057075 NP_001334394، ‏NP_001334395، ‏NP_057075	NP_031598
الموقع (UCSC	n/a	Chr 4: 136.9 – 136.9 Mb
بحث ببمد	[1]	[2]
ويكي بيانات
اعرض/عدّل إنسان اعرض/عدّل فأر

C1QA‏ (Complement C1q A chain) هوَ بروتين يُشَفر بواسطة جين C1QA في الإنسان.

الوظيفة

هذا القسم فارغ أو غير مكتمل، ساهم بتحريره.

الأهمية السريرية

هذا القسم فارغ أو غير مكتمل، ساهم بتحريره.

قراءة متعمقة

• Petry F (1999). "Molecular basis of hereditary C1q deficiency". Immunobiology. 199 (2): 286–94. doi:10.1016/s0171-2985(98)80033-8. PMID 9777412.
• "Interaction of C1q and mannan-binding lectin with viruses". Immunobiology. 205 (4–5): 563–74. 2003. doi:10.1078/0171-2985-00155. PMID 12396016.
• Reid KB (1976). "Isolation, by partial pepsin digestion, of the three collagen-like regions present in subcomponent Clq of the first component of human complement". Biochem. J. 155 (1): 5–17. PMC 1172796. PMID 7240.
• Reid KB (1979). "Complete amino acid sequences of the three collagen-like regions present in subcomponent C1q of the first component of human complement". Biochem. J. 179 (2): 367–71. PMC 1186634. PMID 486087.
• "The proteoglycan decorin binds C1q and inhibits the activity of the C1 complex". J. Immunol. 149 (11): 3695–701. 1992. PMID 1431141.
• "Characterization and organization of the genes encoding the A-, B- and C-chains of human complement subcomponent C1q. The complete derived amino acid sequence of human C1q". Biochem. J. 274 (2): 481–90. 1991. PMC 1150164. PMID 1706597.
• "Human immunodeficiency virus type 1 activates the classical pathway of complement by direct C1 binding through specific sites in the transmembrane glycoprotein gp41". J. Exp. Med. 174 (6): 1417–24. 1992. doi:10.1084/jem.174.6.1417. PMC 2119058. PMID 1744579.
• "Interaction of the envelope glycoprotein of human immunodeficiency virus with C1q and fibronectin under conditions present in human saliva". Mol. Immunol. 28 (8): 811–7. 1991. doi:10.1016/0161-5890(91)90044-K. PMID 1875953.
• "NH2-terminal calcium-binding domain of human complement C1s- mediates the interaction of C1r- with C1q". Biochemistry. 29 (19): 4613–8. 1990. doi:10.1021/bi00471a016. PMID 2372546.
• "Fibronectin binds to the C1q component of complement". Proc. Natl. Acad. Sci. U.S.A. 79 (13): 4198–201. 1982. doi:10.1073/pnas.79.13.4198. PMC 346605. PMID 6981115.
• "Completion of the amino acid sequences of the A and B chains of subcomponent C1q of the first component of human complement". Biochem. J. 203 (3): 559–69. 1982. PMC 1158269. PMID 6981411.
• "The envelope glycoprotein of HIV-1 gp120 and human complement protein C1q bind to the same peptides derived from three different regions of gp41, the transmembrane glycoprotein of HIV-1, and share antigenic homology". Eur. J. Immunol. 24 (2): 294–300. 1994. doi:10.1002/eji.1830240203. PMID 7507842.
• "Interaction of complement and specific antibodies with the external glycoprotein 120 of HIV-1". Immunology. 85 (2): 184–9. 1995. PMC 1383879. PMID 7642209.
• "HIV-1 rsgp41 depends on calcium for binding of human c1q but not for binding of gp120". Mol. Immunol. 32 (5): 371–4. 1995. doi:10.1016/0161-5890(94)00156-U. PMID 7739575.
• "Expression of the components and regulatory proteins of the classical pathway of complement in normal and diseased synovium". Rheumatol. Int. 14 (1): 13–9. 1994. doi:10.1007/BF00302666. PMID 7939135.
• "Regulation of the synthesis of C1 subcomponents and C1-inhibitor". Behring Inst. Mitt. (93): 196–203. 1994. PMID 8172568.
• "Isolation, cDNA cloning, and overexpression of a 33-kD cell surface glycoprotein that binds to the globular "heads" of C1q". J. Exp. Med. 179 (6): 1809–21. 1994. doi:10.1084/jem.179.6.1809. PMC 2191527. PMID 8195709.
• "Further characterization of the interaction between the C1q subcomponent of human C1 and the transmembrane envelope glycoprotein gp41 of HIV-1". J. Immunol. 151 (11): 6583–92. 1994. PMID 8245486.
• "Studies on the mechanism of complement-mediated inhibition of antibody binding to HIV gp41". Clin. Exp. Immunol. 94 (3): 490–3. 1994. doi:10.1111/j.1365-2249.1993.tb08223.x. PMC 1534428. PMID 8252810.

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