ATF6

ATF6
المعرفات
الأسماء المستعارة	ATF6, A, ACHM7, activating transcription factor 6
معرفات خارجية	الوراثة المندلية البشرية عبر الإنترنت 605537 MGI: MGI:1926157 HomoloGene: 32015 GeneCards: 22926
علم الوجود الجيني الوظيفة الجزيئية • ربط دي إن إي • RNA polymerase II regulatory region sequence-specific DNA binding • transcription factor activity, sequence-specific DNA binding • transcription coactivator activity • transcription regulatory region sequence-specific DNA binding • ربط بروتيني • identical protein binding • protein heterodimerization activity • ubiquitin protein ligase binding • cAMP response element binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding • sequence-specific DNA binding • RNA polymerase II transcription factor activity, sequence-specific DNA binding المكونات الخلوية • مكون تكاملي للغشاء • جهاز غولجي • nuclear envelope • غشاء • endoplasmic reticulum membrane • Golgi membrane • بلازم نووي • integral component of endoplasmic reticulum membrane • شبكة إندوبلازمية • نواة • عصارة خلوية العمليات الحيوية • eye development • regulation of transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress • regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • endoplasmic reticulum unfolded protein response • ATF6-mediated unfolded protein response • response to unfolded protein • طي البروتين • توصيل الإشارة • حاسة البصر • positive regulation of apoptotic process • transcription from RNA polymerase II promoter • positive regulation of transcription from RNA polymerase II promoter • positive regulation of ATF6-mediated unfolded protein response المصادر:Amigo / QuickGO
نمط التعبير عن الحمض النووي الريبوزي
المزيد من بيانات التعبير المرجعية
أورثولوج
الأنواع	الإنسان	الفأر
أنتريه	22926	226641
Ensembl	ENSG00000118217	ENSMUSG00000026663
يونيبروت	P18850	F6VAN0
RefSeq (مرسال ر.ن.ا.)	‏NM_007348، ‏XM_006711224، ‏XM_011509308، ‏XM_011509309 XM_011509310، ‏NM_007348، ‏XM_006711224، ‏XM_011509308، ‏XM_011509309	‏XM_006496792، ‏XM_011238796، ‏XM_030253420 NM_001081304، ‏XM_006496792، ‏XM_011238796، ‏XM_030253420
RefSeq (بروتين)	‏XP_006711287، ‏XP_011507610، ‏XP_011507611، ‏XP_011507612 NP_031374، ‏XP_006711287، ‏XP_011507610، ‏XP_011507611، ‏XP_011507612	‏XP_006496855، ‏XP_011237098، ‏XP_030109280 NP_001074773، ‏XP_006496855، ‏XP_011237098، ‏XP_030109280
الموقع (UCSC	n/a	Chr 1: 170.7 – 170.87 Mb
بحث ببمد	[1]	[2]
ويكي بيانات
اعرض/عدّل إنسان اعرض/عدّل فأر

ATF6‏ (Activating transcription factor 6) هوَ بروتين يُشَفر بواسطة جين ATF6 في الإنسان.

الوظيفة

هذا القسم فارغ أو غير مكتمل، ساهم بتحريره.

الأهمية السريرية

هذا القسم فارغ أو غير مكتمل، ساهم بتحريره.

قراءة متعمقة

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• Hai TW، Liu F، Coukos WJ، Green MR (1990). "Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers". Genes Dev. 3 (12B): 2083–90. PMID 2516827. doi:10.1101/gad.3.12b.2083. 
• Zhu C، Johansen FE، Prywes R (1997). "Interaction of ATF6 and serum response factor". Mol. Cell. Biol. 17 (9): 4957–66. PMC 232347. PMID 9271374. 
• Yoshida H، Haze K، Yanagi H، Yura T، Mori K (1999). "Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors". J. Biol. Chem. 273 (50): 33741–9. PMID 9837962. doi:10.1074/jbc.273.50.33741. 
• Haze K، Yoshida H، Yanagi H، Yura T، Mori K (1999). "Mammalian Transcription Factor ATF6 Is Synthesized as a Transmembrane Protein and Activated by Proteolysis in Response to Endoplasmic Reticulum Stress". Mol. Biol. Cell. 10 (11): 3787–99. PMC 25679. PMID 10564271. doi:10.1091/mbc.10.11.3787. 
• Li M، Baumeister P، Roy B، Phan T، Foti D، Luo S، Lee AS (2000). "ATF6 as a Transcription Activator of the Endoplasmic Reticulum Stress Element: Thapsigargin Stress-Induced Changes and Synergistic Interactions with NF-Y and YY1". Mol. Cell. Biol. 20 (14): 5096–106. PMC 85959. PMID 10866666. doi:10.1128/MCB.20.14.5096-5106.2000. 
• Yoshida H، Okada T، Haze K، Yanagi H، Yura T، Negishi M، Mori K (2001). "Endoplasmic Reticulum Stress-Induced Formation of Transcription Factor Complex ERSF Including NF-Y (CBF) and Activating Transcription Factors 6α and 6β That Activates the Mammalian Unfolded Protein Response". Mol. Cell. Biol. 21 (4): 1239–48. PMC 99577. PMID 11158310. doi:10.1128/MCB.21.4.1239-1248.2001. 
• Ye J، Rawson RB، Komuro R، Chen X، Davé UP، Prywes R، Brown MS، Goldstein JL (2001). "ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs". Mol. Cell. 6 (6): 1355–64. PMID 11163209. doi:10.1016/S1097-2765(00)00133-7. 
• Parker R، Phan T، Baumeister P، Roy B، Cheriyath V، Roy AL، Lee AS (2001). "Identification of TFII-I as the Endoplasmic Reticulum Stress Response Element Binding Factor ERSF: Its Autoregulation by Stress and Interaction with ATF6". Mol. Cell. Biol. 21 (9): 3220–33. PMC 86961. PMID 11287625. doi:10.1128/MCB.21.9.3220-3233.2001. 
• Gotoh T، Oyadomari S، Mori K، Mori M (2002). "Nitric oxide-induced apoptosis in RAW 264.7 macrophages is mediated by endoplasmic reticulum stress pathway involving ATF6 and CHOP". J. Biol. Chem. 277 (14): 12343–50. PMID 11805088. doi:10.1074/jbc.M107988200. 
• Chen X، Shen J، Prywes R (2002). "The luminal domain of ATF6 senses endoplasmic reticulum (ER) stress and causes translocation of ATF6 from the ER to the Golgi". J. Biol. Chem. 277 (15): 13045–52. PMID 11821395. doi:10.1074/jbc.M110636200. 
• Thuerauf DJ، Morrison LE، Hoover H، Glembotski CC (2002). "Coordination of ATF6-mediated transcription and ATF6 degradation by a domain that is shared with the viral transcription factor, VP16". J. Biol. Chem. 277 (23): 20734–9. PMID 11909875. doi:10.1074/jbc.M201749200. 
• Okada T، Yoshida H، Akazawa R، Negishi M، Mori K (2002). "Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein response". Biochem. J. 366 (Pt 2): 585–94. PMC 1222788. PMID 12014989. doi:10.1042/BJ20020391. 
• Luo S، Lee AS (2002). "Requirement of the p38 mitogen-activated protein kinase signalling pathway for the induction of the 78 kDa glucose-regulated protein/immunoglobulin heavy-chain binding protein by azetidine stress: activating transcription factor 6 as a target for stress-induced phosphorylation". Biochem. J. 366 (Pt 3): 787–95. PMC 1222838. PMID 12076252. doi:10.1042/BJ20011802. 
• Tardif KD، Mori K، Siddiqui A (2002). "Hepatitis C Virus Subgenomic Replicons Induce Endoplasmic Reticulum Stress Activating an Intracellular Signaling Pathway". J. Virol. 76 (15): 7453–9. PMC 136367. PMID 12097557. doi:10.1128/JVI.76.15.7453-7459.2002. 
• Shuda M، Kondoh N، Imazeki N، Tanaka K، Okada T، Mori K، Hada A، Arai M، Wakatsuki T، Matsubara O، Yamamoto N، Yamamoto M (2004). "Activation of the ATF6, XBP1 and grp78 genes in human hepatocellular carcinoma: a possible involvement of the ER stress pathway in hepatocarcinogenesis". J. Hepatol. 38 (5): 605–14. PMID 12713871. doi:10.1016/S0168-8278(03)00029-1. 
• Okada T، Haze K، Nadanaka S، Yoshida H، Seidah NG، Hirano Y، Sato R، Negishi M، Mori K (2003). "A serine protease inhibitor prevents endoplasmic reticulum stress-induced cleavage but not transport of the membrane-bound transcription factor ATF6". J. Biol. Chem. 278 (33): 31024–32. PMID 12782636. doi:10.1074/jbc.M300923200. 
• Newman JR، Keating AE (2003). "Comprehensive identification of human bZIP interactions with coiled-coil arrays". Science. 300 (5628): 2097–101. PMID 12805554. doi:10.1126/science.1084648. 

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