HES5

HES5
المعرفات
الأسماء المستعارة	HES5, bHLHb38, hes family bHLH transcription factor 5
معرفات خارجية	الوراثة المندلية البشرية عبر الإنترنت 607348 MGI: MGI:104876 HomoloGene: 7755 GeneCards: 388585
علم الوجود الجيني الوظيفة الجزيئية • ربط دي إن إي • protein dimerization activity • transcription factor binding • chromatin binding • ‏GO:0001078، ‏GO:0001214، ‏GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • double-stranded DNA binding • ‏GO:0001200، ‏GO:0001133، ‏GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • RNA polymerase II transcription regulatory region sequence-specific DNA binding • ‏GO:0001106 transcription corepressor activity • sequence-specific DNA binding • sequence-specific double-stranded DNA binding المكونات الخلوية • بلازم نووي • نواة • مكون خلوي العمليات الحيوية • Notch signaling pathway • auditory receptor cell fate determination • establishment of epithelial cell polarity • تمايز خلوي • negative regulation of astrocyte differentiation • regulation of inner ear auditory receptor cell differentiation • ضبط نسخ الدنا • negative regulation of neuron differentiation • inner ear receptor cell stereocilium organization • comma-shaped body morphogenesis • metanephric nephron tubule morphogenesis • chondrocyte differentiation • central nervous system myelination • negative regulation of transcription by RNA polymerase II • cell maturation • negative regulation of forebrain neuron differentiation • نسخ الدنا • نماء عصبي • negative regulation of stem cell differentiation • neuronal stem cell population maintenance • positive regulation of transcription, DNA-templated • نمو متعدد الخلايا • glial cell fate commitment • telencephalon development • brain development • inner ear auditory receptor cell differentiation • التصاق الخلايا • astrocyte differentiation • تَكوّن الغُضروف • forebrain radial glial cell differentiation • regulation of myelination • negative regulation of oligodendrocyte differentiation • S-shaped body morphogenesis • neural tube development • neuron differentiation • ضبط زيادي للتكاثر الخلوي • positive regulation of BMP signaling pathway • negative regulation of pro-B cell differentiation • regulation of cell differentiation • smoothened signaling pathway • oligodendrocyte development • camera-type eye development • specification of loop of Henle identity • regulation of epithelial cell proliferation • negative regulation of transcription, DNA-templated • negative regulation of inner ear receptor cell differentiation • regulation of neurogenesis • positive regulation of receptor signaling pathway via JAK-STAT • positive regulation of Notch signaling pathway • ضبط زيادي للنسخ انطلاقا من محفز بوليميراز الرنا الثاني • positive regulation of smooth muscle cell proliferation • positive regulation of tyrosine phosphorylation of STAT protein • protein-containing complex assembly • تكون الجسيدات • central nervous system development • نقل شاردة الكالسيوم • negative regulation of inner ear auditory receptor cell differentiation المصادر:Amigo / QuickGO
أورثولوج
الأنواع	الإنسان	الفأر
أنتريه	388585	15208
Ensembl	‏ENSG00000197921;db=core ENSG00000273529، ‏ENSG00000197921	ENSMUSG00000048001
يونيبروت	Q5TA89	P70120
RefSeq (مرسال ر.ن.ا.)	‏XM_005244751 NM_001010926، ‏XM_005244751	‏XM_006538562، ‏NM_001370755 NM_010419، ‏XM_006538562، ‏NM_001370755
RefSeq (بروتين)	‏XP_005244808 NP_001010926، ‏XP_005244808	‏XP_006538625، ‏NP_001357684 NP_034549، ‏XP_006538625، ‏NP_001357684
الموقع (UCSC	n/a	Chr 4: 155.05 – 155.05 Mb
بحث ببمد	[1]	[2]
ويكي بيانات
اعرض/عدّل إنسان اعرض/عدّل فأر

HES5‏ (Hes family bHLH transcription factor 5) هوَ بروتين يُشَفر بواسطة جين HES5 في الإنسان.

قراءة متعمقة

• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences."، Proc. Natl. Acad. Sci. U.S.A.، 99 (26): 16899–903، 2003، doi:10.1073/pnas.242603899، PMC 139241، PMID 12477932.
• "Math1 controls cerebellar granule cell differentiation by regulating multiple components of the Notch signaling pathway."، Development، 131 (4): 903–13، 2004، doi:10.1242/dev.00982، PMID 14757642.
• "Helt, a novel basic-helix-loop-helix transcriptional repressor expressed in the developing central nervous system."، J. Biol. Chem.، 279 (16): 16356–67، 2004، doi:10.1074/jbc.M311740200، PMID 14764602.
• "Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling."، Nat. Cell Biol.، 6 (6): 547–54، 2004، doi:10.1038/ncb1138، PMID 15156153.
• "Identification and characterization of human HES2, HES3, and HES5 genes in silico."، Int. J. Oncol.، 25 (2): 529–34، 2005، doi:10.3892/ijo.25.2.529، PMID 15254753.
• "Visualization of embryonic neural stem cells using Hes promoters in transgenic mice."، Mol. Cell. Neurosci.، 31 (1): 109–22، 2006، doi:10.1016/j.mcn.2005.09.006، PMID 16214363.
• "Target selectivity of vertebrate notch proteins. Collaboration between discrete domains and CSL-binding site architecture determines activation probability."، J. Biol. Chem.، 281 (8): 5106–19، 2006، doi:10.1074/jbc.M506108200، PMID 16365048.
• "The DNA sequence and biological annotation of human chromosome 1."، Nature، 441 (7091): 315–21، 2006، doi:10.1038/nature04727، PMID 16710414.
• "Differentiation of human mesenchymal stem cells and articular chondrocytes: analysis of chondrogenic potential and expression pattern of differentiation-related transcription factors."، J. Orthop. Res.، 25 (2): 152–63، 2007، doi:10.1002/jor.20287، PMID 17072841.
• "Notch and HES5 are regulated during human cartilage differentiation."، Cell Tissue Res.، 327 (3): 539–51، 2007، doi:10.1007/s00441-006-0307-0، PMID 17093926.