HES5

HES5
المعرفات
الأسماء المستعارة	HES5, bHLHb38, hes family bHLH transcription factor 5
معرفات خارجية	الوراثة المندلية البشرية عبر الإنترنت 607348 MGI: MGI:104876 HomoloGene: 7755 GeneCards: 388585
علم الوجود الجيني الوظيفة الجزيئية • ربط دي إن إي • protein dimerization activity • transcription factor binding • chromatin binding • ‏GO:0001078، ‏GO:0001214، ‏GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • double-stranded DNA binding • ‏GO:0001200، ‏GO:0001133، ‏GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • RNA polymerase II regulatory region sequence-specific DNA binding • ‏GO:0001106 transcription corepressor activity • sequence-specific DNA binding • sequence-specific double-stranded DNA binding المكونات الخلوية • بلازم نووي • نواة • مكون خلوي العمليات الحيوية • Notch signaling pathway • auditory receptor cell fate determination • establishment of epithelial cell polarity • تمايز خلوي • negative regulation of astrocyte differentiation • regulation of auditory receptor cell differentiation • regulation of transcription, DNA-templated • negative regulation of neuron differentiation • inner ear receptor stereocilium organization • comma-shaped body morphogenesis • metanephric nephron tubule morphogenesis • chondrocyte differentiation • central nervous system myelination • negative regulation of transcription from RNA polymerase II promoter • cell maturation • negative regulation of forebrain neuron differentiation • transcription, DNA-templated • nervous system development • negative regulation of stem cell differentiation • neuronal stem cell population maintenance • positive regulation of transcription, DNA-templated • multicellular organism development • glial cell fate commitment • telencephalon development • brain development • auditory receptor cell differentiation • التصاق الخلايا • astrocyte differentiation • cartilage development • forebrain radial glial cell differentiation • regulation of myelination • negative regulation of oligodendrocyte differentiation • S-shaped body morphogenesis • neural tube development • neuron differentiation • positive regulation of cell proliferation • positive regulation of BMP signaling pathway • negative regulation of pro-B cell differentiation • regulation of cell differentiation • smoothened signaling pathway • oligodendrocyte development • camera-type eye development • specification of loop of Henle identity • regulation of epithelial cell proliferation • negative regulation of transcription, DNA-templated • negative regulation of inner ear receptor cell differentiation • regulation of neurogenesis • positive regulation of JAK-STAT cascade • positive regulation of Notch signaling pathway • positive regulation of transcription from RNA polymerase II promoter • positive regulation of smooth muscle cell proliferation • positive regulation of tyrosine phosphorylation of STAT protein • macromolecular complex assembly • تكون الجسيدات • central nervous system development • anterior/posterior pattern specification • negative regulation of auditory receptor cell differentiation المصادر:Amigo / QuickGO
أورثولوج
الأنواع	الإنسان	الفأر
أنتريه	388585	15208
Ensembl	‏ENSG00000197921;db=core ENSG00000273529، ‏ENSG00000197921	ENSMUSG00000048001
يونيبروت	Q5TA89	P70120
RefSeq (مرسال ر.ن.ا.)	‏XM_005244751 NM_001010926، ‏XM_005244751	‏XM_006538562، ‏NM_001370755 NM_010419، ‏XM_006538562، ‏NM_001370755
RefSeq (بروتين)	‏XP_005244808 NP_001010926، ‏XP_005244808	‏XP_006538625، ‏NP_001357684 NP_034549، ‏XP_006538625، ‏NP_001357684
الموقع (UCSC	n/a	Chr 4: 154.96 – 154.96 Mb
بحث ببمد	[1]	[2]
ويكي بيانات
اعرض/عدّل إنسان اعرض/عدّل فأر

HES5‏ (Hes family bHLH transcription factor 5) هوَ بروتين يُشَفر بواسطة جين HES5 في الإنسان.

الوظيفة

هذا القسم فارغ أو غير مكتمل، ساهم بتحريره.

الأهمية السريرية

هذا القسم فارغ أو غير مكتمل، ساهم بتحريره.

قراءة متعمقة

• Strausberg RL، Feingold EA، Grouse LH، et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241. PMID 12477932. doi:10.1073/pnas.242603899. 
• Gazit R، Krizhanovsky V، Ben-Arie N (2004). "Math1 controls cerebellar granule cell differentiation by regulating multiple components of the Notch signaling pathway.". Development. 131 (4): 903–13. PMID 14757642. doi:10.1242/dev.00982. 
• Nakatani T، Mizuhara E، Minaki Y، et al. (2004). "Helt, a novel basic-helix-loop-helix transcriptional repressor expressed in the developing central nervous system.". J. Biol. Chem. 279 (16): 16356–67. PMID 14764602. doi:10.1074/jbc.M311740200. 
• Kamakura S، Oishi K، Yoshimatsu T، et al. (2004). "Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling.". Nat. Cell Biol. 6 (6): 547–54. PMID 15156153. doi:10.1038/ncb1138. 
• Katoh M، Katoh M (2005). "Identification and characterization of human HES2, HES3, and HES5 genes in silico.". Int. J. Oncol. 25 (2): 529–34. PMID 15254753. doi:10.3892/ijo.25.2.529. 
• Ohtsuka T، Imayoshi I، Shimojo H، et al. (2006). "Visualization of embryonic neural stem cells using Hes promoters in transgenic mice.". Mol. Cell. Neurosci. 31 (1): 109–22. PMID 16214363. doi:10.1016/j.mcn.2005.09.006. 
• Ong CT، Cheng HT، Chang LW، et al. (2006). "Target selectivity of vertebrate notch proteins. Collaboration between discrete domains and CSL-binding site architecture determines activation probability.". J. Biol. Chem. 281 (8): 5106–19. PMID 16365048. doi:10.1074/jbc.M506108200. 
• Gregory SG، Barlow KF، McLay KE، et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature. 441 (7091): 315–21. PMID 16710414. doi:10.1038/nature04727. 
• Karlsson C، Brantsing C، Svensson T، et al. (2007). "Differentiation of human mesenchymal stem cells and articular chondrocytes: analysis of chondrogenic potential and expression pattern of differentiation-related transcription factors.". J. Orthop. Res. 25 (2): 152–63. PMID 17072841. doi:10.1002/jor.20287. 
• Karlsson C، Jonsson M، Asp J، et al. (2007). "Notch and HES5 are regulated during human cartilage differentiation.". Cell Tissue Res. 327 (3): 539–51. PMID 17093926. doi:10.1007/s00441-006-0307-0. 

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