HES5

HES5
المعرفات
الأسماء المستعارة	HES5, bHLHb38, hes family bHLH transcription factor 5
معرفات خارجية	الوراثة المندلية البشرية عبر الإنترنت 607348 MGI: MGI:104876 HomoloGene: 7755 GeneCards: 388585
علم الوجود الجيني
الوظيفة الجزيئية	• ربط دي إن إي; • protein dimerization activity; • transcription factor binding; • chromatin binding; • ‏GO:0001078، ‏GO:0001214، ‏GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific; • double-stranded DNA binding; • ‏GO:0001200، ‏GO:0001133، ‏GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • RNA polymerase II regulatory region sequence-specific DNA binding; • ‏GO:0001106 transcription corepressor activity; • sequence-specific DNA binding; • sequence-specific double-stranded DNA binding;
المكونات الخلوية	• بلازم نووي; • نواة; • مكون خلوي;
العمليات الحيوية	• Notch signaling pathway; • auditory receptor cell fate determination; • establishment of epithelial cell polarity; • تمايز خلوي; • negative regulation of astrocyte differentiation; • regulation of auditory receptor cell differentiation; • ضبط نسخ الدنا; • negative regulation of neuron differentiation; • inner ear receptor stereocilium organization; • comma-shaped body morphogenesis; • metanephric nephron tubule morphogenesis; • chondrocyte differentiation; • central nervous system myelination; • negative regulation of transcription from RNA polymerase II promoter; • cell maturation; • negative regulation of forebrain neuron differentiation; • نسخ الدنا; • نماء عصبي; • negative regulation of stem cell differentiation; • neuronal stem cell population maintenance; • positive regulation of transcription, DNA-templated; • نمو متعدد الخلايا; • glial cell fate commitment; • telencephalon development; • brain development; • auditory receptor cell differentiation; • التصاق الخلايا; • astrocyte differentiation; • نمو الغضروف; • forebrain radial glial cell differentiation; • regulation of myelination; • negative regulation of oligodendrocyte differentiation; • S-shaped body morphogenesis; • neural tube development; • neuron differentiation; • ضبط زيادي للتكاثر الخلوي; • positive regulation of BMP signaling pathway; • negative regulation of pro-B cell differentiation; • regulation of cell differentiation; • smoothened signaling pathway; • oligodendrocyte development; • camera-type eye development; • specification of loop of Henle identity; • regulation of epithelial cell proliferation; • negative regulation of transcription, DNA-templated; • negative regulation of inner ear receptor cell differentiation; • regulation of neurogenesis; • positive regulation of JAK-STAT cascade; • positive regulation of Notch signaling pathway; • ضبط زيادي للنسخ انطلاقا من محفز بوليميراز الرنا الثاني; • positive regulation of smooth muscle cell proliferation; • positive regulation of tyrosine phosphorylation of STAT protein; • macromolecular complex assembly; • تكون الجسيدات; • central nervous system development; • نقل شاردة الكالسيوم; • negative regulation of auditory receptor cell differentiation;
	المصادر:Amigo / QuickGO
أورثولوج
	Q5TA89
	P70120
	‏XM_005244751 NM_001010926، ‏XM_005244751
	‏XM_006538562، ‏NM_001370755 NM_010419، ‏XM_006538562، ‏NM_001370755
	‏XP_005244808 NP_001010926، ‏XP_005244808
	‏XP_006538625، ‏NP_001357684 NP_034549، ‏XP_006538625، ‏NP_001357684
	ويكي بيانات
اعرض/عدّل إنسان	اعرض/عدّل فأر

HES5‏ (Hes family bHLH transcription factor 5) هوَ بروتين يُشَفر بواسطة جين HES5 في الإنسان.^[1]^[2]^[3]^[4]^[5]

الوظيفة[عدل]

هذا القسم فارغ أو غير مكتمل، ساهم بتحريره.

الأهمية السريرية[عدل]

هذا القسم فارغ أو غير مكتمل، ساهم بتحريره.

المراجع[عدل]

^ Takebayashi K, Akazawa C, Nakanishi S, Kageyama R (Feb 1995). "Structure and promoter analysis of the gene encoding the mouse helix-loop-helix factor HES-5. Identification of the neural precursor cell-specific promoter element". J Biol Chem. 270 (3): 1342–9. doi:10.1074/jbc.270.3.1342. PMID 7836401. الوسيط |CitationClass= تم تجاهله (مساعدة)
^ Hatakeyama J, Bessho Y, Katoh K, Ookawara S, Fujioka M, Guillemot F, Kageyama R (November 2004). "Hes genes regulate size, shape and histogenesis of the nervous system by control of the timing of neural stem cell differentiation". Development. 131 (22): 5539–50. doi:10.1242/dev.01436. PMID 15496443. الوسيط |CitationClass= تم تجاهله (مساعدة)
^ Liu J, Ye F, Chen H, Lü W, Zhou C, Xie X (2007). "Expression of differentiation associated protein Hes1 and Hes5 in cervical squamous carcinoma and its precursors". Int. J. Gynecol. Cancer. 17 (6): 1293–9. doi:10.1111/j.1525-1438.2007.00930.x. PMID 17388915. الوسيط |CitationClass= تم تجاهله (مساعدة)
^ "Entrez Gene: HES5 hairy and enhancer of split 5 (Drosophila)". مؤرشف من الأصل في 05 ديسمبر 2010. الوسيط |CitationClass= تم تجاهله (مساعدة)
^ Karlsson C, Jonsson M, Asp J, Brantsing C, Kageyama R, Lindahl A (March 2007). "Notch and HES5 are regulated during human cartilage differentiation". Cell Tissue Res. 327 (3): 539–51. doi:10.1007/s00441-006-0307-0. PMID 17093926. الوسيط |CitationClass= تم تجاهله (مساعدة)

قراءة متعمقة[عدل]

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. الوسيط |CitationClass= تم تجاهله (مساعدة)
Gazit R, Krizhanovsky V, Ben-Arie N (2004). "Math1 controls cerebellar granule cell differentiation by regulating multiple components of the Notch signaling pathway". Development. 131 (4): 903–13. doi:10.1242/dev.00982. PMID 14757642. الوسيط |CitationClass= تم تجاهله (مساعدة)
Nakatani T, Mizuhara E, Minaki Y, et al. (2004). "Helt, a novel basic-helix-loop-helix transcriptional repressor expressed in the developing central nervous system". J. Biol. Chem. 279 (16): 16356–67. doi:10.1074/jbc.M311740200. PMID 14764602. الوسيط |CitationClass= تم تجاهله (مساعدة)
Kamakura S, Oishi K, Yoshimatsu T, et al. (2004). "Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling". Nat. Cell Biol. 6 (6): 547–54. doi:10.1038/ncb1138. PMID 15156153. الوسيط |CitationClass= تم تجاهله (مساعدة)
Katoh M, Katoh M (2005). "Identification and characterization of human HES2, HES3, and HES5 genes in silico". Int. J. Oncol. 25 (2): 529–34. doi:10.3892/ijo.25.2.529. PMID 15254753. الوسيط |CitationClass= تم تجاهله (مساعدة)
Ohtsuka T, Imayoshi I, Shimojo H, et al. (2006). "Visualization of embryonic neural stem cells using Hes promoters in transgenic mice". Mol. Cell. Neurosci. 31 (1): 109–22. doi:10.1016/j.mcn.2005.09.006. PMID 16214363. الوسيط |CitationClass= تم تجاهله (مساعدة)
Ong CT, Cheng HT, Chang LW, et al. (2006). "Target selectivity of vertebrate notch proteins. Collaboration between discrete domains and CSL-binding site architecture determines activation probability". J. Biol. Chem. 281 (8): 5106–19. doi:10.1074/jbc.M506108200. PMID 16365048. الوسيط |CitationClass= تم تجاهله (مساعدة)
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414. الوسيط |CitationClass= تم تجاهله (مساعدة)
Karlsson C, Brantsing C, Svensson T, et al. (2007). "Differentiation of human mesenchymal stem cells and articular chondrocytes: analysis of chondrogenic potential and expression pattern of differentiation-related transcription factors". J. Orthop. Res. 25 (2): 152–63. doi:10.1002/jor.20287. PMID 17072841. الوسيط |CitationClass= تم تجاهله (مساعدة)
Karlsson C, Jonsson M, Asp J, et al. (2007). "Notch and HES5 are regulated during human cartilage differentiation". Cell Tissue Res. 327 (3): 539–51. doi:10.1007/s00441-006-0307-0. PMID 17093926. الوسيط |CitationClass= تم تجاهله (مساعدة)

هذه بذرة مقالة عن جين على كروموسوم 1 بحاجة للتوسيع. شارك في تحريرها.

[pmid7836401-1] Takebayashi K, Akazawa C, Nakanishi S, Kageyama R (Feb 1995). "Structure and promoter analysis of the gene encoding the mouse helix-loop-helix factor HES-5. Identification of the neural precursor cell-specific promoter element". J Biol Chem. 270 (3): 1342–9. doi:10.1074/jbc.270.3.1342. PMID 7836401. الوسيط |CitationClass= تم تجاهله (مساعدة)

[pmid15496443-2] Hatakeyama J, Bessho Y, Katoh K, Ookawara S, Fujioka M, Guillemot F, Kageyama R (November 2004). "Hes genes regulate size, shape and histogenesis of the nervous system by control of the timing of neural stem cell differentiation". Development. 131 (22): 5539–50. doi:10.1242/dev.01436. PMID 15496443. الوسيط |CitationClass= تم تجاهله (مساعدة)

[pmid17388915-3] Liu J, Ye F, Chen H, Lü W, Zhou C, Xie X (2007). "Expression of differentiation associated protein Hes1 and Hes5 in cervical squamous carcinoma and its precursors". Int. J. Gynecol. Cancer. 17 (6): 1293–9. doi:10.1111/j.1525-1438.2007.00930.x. PMID 17388915. الوسيط |CitationClass= تم تجاهله (مساعدة)

[entrez-4] "Entrez Gene: HES5 hairy and enhancer of split 5 (Drosophila)". مؤرشف من الأصل في 05 ديسمبر 2010. الوسيط |CitationClass= تم تجاهله (مساعدة)

[pmid17093926-5] Karlsson C, Jonsson M, Asp J, Brantsing C, Kageyama R, Lindahl A (March 2007). "Notch and HES5 are regulated during human cartilage differentiation". Cell Tissue Res. 327 (3): 539–51. doi:10.1007/s00441-006-0307-0. PMID 17093926. الوسيط |CitationClass= تم تجاهله (مساعدة)

[1]

[2]

[3]

[4]

[5]

HES5

محتويات

الوظيفة[عدل]

الأهمية السريرية[عدل]

المراجع[عدل]

قراءة متعمقة[عدل]

قائمة التصفح

بحث