S100A6

S100A6
التراكيب المتوفرة بنك بيانات البروتين Ortholog search: PDBe RCSB قائمة رموز معرفات بنك بيانات البروتين 1K8U, 1K96, 1K9K, 1K9P, 2M1K, 4YBH
المعرفات
الأسماء المستعارة	S100A6, 2A9, 5B10, CABP, CACY, PRA, S100 calcium binding protein A6, S10A6
معرفات خارجية	الوراثة المندلية البشرية عبر الإنترنت 114110 MGI: MGI:1339467 HomoloGene: 7925 GeneCards: 6277
علم الوجود الجيني الوظيفة الجزيئية • ربط أيون الكالسيوم • S100 protein binding • protein homodimerization activity • ion transmembrane transporter activity • ربط أيون الزنك • ربط أيون فلزي • calcium-dependent protein binding • ‏GO:0001948 ربط بروتيني • tropomyosin binding المكونات الخلوية • سيتوبلازم • عصارة خلوية • nuclear envelope • غشاء • ruffle • extrinsic component of cytoplasmic side of plasma membrane • غشاء خلوي • perinuclear region of cytoplasm • extracellular exosome • نواة • منطقة خارج الخلية • collagen-containing extracellular matrix العمليات الحيوية • axonogenesis • positive regulation of fibroblast proliferation • ion transmembrane transport • توصيل الإشارة المصادر:Amigo / QuickGO
أورثولوج
الأنواع	الإنسان	الفأر
أنتريه	6277	20200
Ensembl	ENSG00000197956	ENSMUSG00000001025
يونيبروت	P06703	P14069
RefSeq (مرسال ر.ن.ا.)	‏XM_017002033 NM_014624، ‏XM_017002033	NM_011313
RefSeq (بروتين)	‏XP_016857522 NP_055439، ‏XP_016857522	NP_035443
الموقع (UCSC	n/a	Chr 3: 90.61 – 90.62 Mb
بحث ببمد	[1]	[2]
ويكي بيانات
اعرض/عدّل إنسان اعرض/عدّل فأر

S100A6‏ (S100 calcium binding protein A6) هوَ بروتين يُشَفر بواسطة جين S100A6 في الإنسان.

الوظيفة

هذا القسم فارغ أو غير مكتمل، ساهم بتحريره.

الأهمية السريرية

هذا القسم فارغ أو غير مكتمل، ساهم بتحريره.

قراءة متعمقة

• Schäfer BW, Heizmann CW (1996). "The S100 family of EF-hand calcium-binding proteins: functions and pathology". Trends Biochem. Sci. 21 (4): 134–40. doi:10.1016/S0968-0004(96)80167-8. PMID 8701470.
• Minami H, Tokumitsu H, Mizutani A, Watanabe Y, Watanabe M, Hidaka H (1992). "Specific binding of CAP-50 to calcyclin". FEBS Lett. 305 (3): 217–9. doi:10.1016/0014-5793(92)80671-3. PMID 1299619.
• Engelkamp D, Schäfer BW, Erne P, Heizmann CW (1992). "S100 alpha, CAPL, and CACY: molecular cloning and expression analysis of three calcium-binding proteins from human heart". Biochemistry. 31 (42): 10258–64. doi:10.1021/bi00157a012. PMID 1384693.
• Tomida Y, Terasawa M, Kobayashi R, Hidaka H (1992). "Calcyclin and calvasculin exist in human platelets". Biochem. Biophys. Res. Commun. 189 (3): 1310–6. doi:10.1016/0006-291X(92)90216-8. PMID 1482346.
• Filipek A, Gerke V, Weber K, Kuźnicki J (1991). "Characterization of the cell-cycle-regulated protein calcyclin from Ehrlich ascites tumor cells. Identification of two binding proteins obtained by Ca2(+)-dependent affinity chromatography". Eur. J. Biochem. 195 (3): 795–800. doi:10.1111/j.1432-1033.1991.tb15768.x. PMID 1999197.
• Murphy LC, Murphy LJ, Tsuyuki D, Duckworth ML, Shiu RP (1988). "Cloning and characterization of a cDNA encoding a highly conserved, putative calcium binding protein, identified by an anti-prolactin receptor antiserum". J. Biol. Chem. 263 (5): 2397–401. PMID 2448309.
• Gabius HJ, Bardosi A, Gabius S, Hellmann KP, Karas M, Kratzin H (1989). "Identification of a cell cycle-dependent gene product as a sialic acid-binding protein". Biochem. Biophys. Res. Commun. 163 (1): 506–12. doi:10.1016/0006-291X(89)92166-9. PMID 2775283.
• Ferrari S, Calabretta B, deRiel JK, Battini R, Ghezzo F, Lauret E, Griffin C, Emanuel BS, Gurrieri F, Baserga R (1987). "Structural and functional analysis of a growth-regulated gene, the human calcyclin". J. Biol. Chem. 262 (17): 8325–32. PMID 3036810.
• Calabretta B, Battini R, Kaczmarek L, de Riel JK, Baserga R (1986). "Molecular cloning of the cDNA for a growth factor-inducible gene with strong homology to S-100, a calcium-binding protein". J. Biol. Chem. 261 (27): 12628–32. PMID 3755724.
• Schäfer BW, Wicki R, Engelkamp D, Mattei MG, Heizmann CW (1995). "Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family". Genomics. 25 (3): 638–43. doi:10.1016/0888-7543(95)80005-7. PMID 7759097.
• Engelkamp D, Schäfer BW, Mattei MG, Erne P, Heizmann CW (1993). "Six S100 genes are clustered on human chromosome 1q21: identification of two genes coding for the two previously unreported calcium-binding proteins S100D and S100E". Proc. Natl. Acad. Sci. U.S.A. 90 (14): 6547–51. doi:10.1073/pnas.90.14.6547. PMC 46969. PMID 8341667.
• Filipek A, Wojda U (1996). "p30, a novel protein target of mouse calcyclin (S100A6)". Biochem. J. 320 ( Pt 2) (Pt 2): 585–7. PMC 1217969. PMID 8973570.
• Kordowska J, Stafford WF, Wang CL (1998). "Ca2+ and Zn2+ bind to different sites and induce different conformational changes in human calcyclin". Eur. J. Biochem. 253 (1): 57–66. doi:10.1046/j.1432-1327.1998.2530057.x. PMID 9578461.
• Yang Q, O'Hanlon D, Heizmann CW, Marks A (1999). "Demonstration of heterodimer formation between S100B and S100A6 in the yeast two-hybrid system and human melanoma". Exp. Cell Res. 246 (2): 501–9. doi:10.1006/excr.1998.4314. PMID 9925766.
• Sudo T, Hidaka H (1999). "Characterization of the calcyclin (S100A6) binding site of annexin XI-A by site-directed mutagenesis". FEBS Lett. 444 (1): 11–4. doi:10.1016/S0014-5793(99)00014-9. PMID 10037139.
• Deloulme JC, Assard N, Mbele GO, Mangin C, Kuwano R, Baudier J (2000). "S100A6 and S100A11 are specific targets of the calcium- and zinc-binding S100B protein in vivo". J. Biol. Chem. 275 (45): 35302–10. doi:10.1074/jbc.M003943200. PMID 10913138.
• Li Y, Yang L, Cui JT, Li WM, Guo RF, Lu YY (2002). "Construction of cDNA representational difference analysis based on two cDNA libraries and identification of garlic inducible expression genes in human gastric cancer cells". World J. Gastroenterol. 8 (2): 208–12. PMID 11925593.
• Otterbein LR, Kordowska J, Witte-Hoffmann C, Wang CL, Dominguez R (2002). "Crystal structures of S100A6 in the Ca(2+)-free and Ca(2+)-bound states: the calcium sensor mechanism of S100 proteins revealed at atomic resolution". Structure. 10 (4): 557–67. doi:10.1016/S0969-2126(02)00740-2. PMID 11937060.
• Filipek A, Jastrzebska B, Nowotny M, Kuznicki J (2002). "CacyBP/SIP, a calcyclin and Siah-1-interacting protein, binds EF-hand proteins of the S100 family". J. Biol. Chem. 277 (32): 28848–52. doi:10.1074/jbc.M203602200. PMID 12042313.

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