ISG15
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هذا القسم فارغ أو غير مكتمل، ساهم بتحريره.
هذا القسم فارغ أو غير مكتمل، ساهم بتحريره.
ISG15 (ISG15 ubiquitin-like modifier) هوَ بروتين يُشَفر بواسطة جين ISG15 في الإنسان.[1][2][3]
الوظيفة[عدل]
هذا القسم فارغ أو غير مكتمل، ساهم بتحريره.الأهمية السريرية[عدل]
هذا القسم فارغ أو غير مكتمل، ساهم بتحريره.المراجع[عدل]
- ^ Morales، David J.؛ Lenschow، Deborah J. (December 2013). "The Antiviral Activities of ISG15". Journal of Molecular Biology. 425 (24): 4995–5008. PMC 4090058
. doi:10.1016/j.jmb.2013.09.041.
- ^ Blomstrom DC، Fahey D، Kutny R، Korant BD، Knight E Jr (Aug 1986). "Molecular characterization of the interferon-induced 15-kDa protein. Molecular cloning and nucleotide and amino acid sequence". J Biol Chem. 261 (19): 8811–6. PMID 3087979.
- ^ "Entrez Gene: ISG15 ISG15 ubiquitin-like modifier".
قراءة متعمقة[عدل]
- Dastur A، Beaudenon S، Kelley M، Krug RM، Huibregtse JM (February 2006). "Herc5, an interferon-induced HECT E3 enzyme, is required for conjugation of ISG15 in human cells". J. Biol. Chem. 281 (7): 4334–8. PMID 16407192. doi:10.1074/jbc.M512830200.
- Bektas N، Noetzel E، Veeck J، وآخرون. (2008). "The ubiquitin-like molecule interferon-stimulated gene 15 (ISG15) is a potential prognostic marker in human breast cancer". Breast Cancer Res. 10 (4): R58. PMC 2575531. PMID 18627608. doi:10.1186/bcr2117.
- Andersen JB، Hassel BA (2007). "The interferon regulated ubiquitin-like protein, ISG15, in tumorigenesis: friend or foe?". Cytokine Growth Factor Rev. 17 (6): 411–21. PMID 17097911. doi:10.1016/j.cytogfr.2006.10.001.
- Loeb KR، Haas AL (1992). "The interferon-inducible 15-kDa ubiquitin homolog conjugates to intracellular proteins". J. Biol. Chem. 267 (11): 7806–13. PMID 1373138.
- Clauss IM، Wathelet MG، Szpirer J، وآخرون. (1990). "Chromosomal localization of two human genes inducible by interferons, double-stranded RNA, and viruses". Cytogenet. Cell Genet. 53 (2–3): 166–8. PMID 1695131. doi:10.1159/000132920.
- Knight E، Cordova B (1991). "IFN-induced 15-kDa protein is released from human lymphocytes and monocytes". J. Immunol. 146 (7): 2280–4. PMID 2005397.
- Haas AL، Ahrens P، Bright PM، Ankel H (1987). "Interferon induces a 15-kilodalton protein exhibiting marked homology to ubiquitin". J. Biol. Chem. 262 (23): 11315–23. PMID 2440890.
- Feltham N، Hillman M، Cordova B، وآخرون. (1989). "A 15-kD interferon-induced protein and its 17-kD precursor: expression in Escherichia coli, purification, and characterization". J. Interferon Res. 9 (5): 493–507. PMID 2477469. doi:10.1089/jir.1989.9.493.
- Knight E، Fahey D، Cordova B، وآخرون. (1988). "A 15-kDa interferon-induced protein is derived by COOH-terminal processing of a 17-kDa precursor". J. Biol. Chem. 263 (10): 4520–2. PMID 3350799.
- Reich N، Evans B، Levy D، وآخرون. (1987). "Interferon-induced transcription of a gene encoding a 15-kDa protein depends on an upstream enhancer element". Proc. Natl. Acad. Sci. U.S.A. 84 (18): 6394–8. PMC 299082. PMID 3476954. doi:10.1073/pnas.84.18.6394.
- Lowe J، McDermott H، Loeb K، وآخرون. (1996). "Immunohistochemical localization of ubiquitin cross-reactive protein in human tissues". J. Pathol. 177 (2): 163–9. PMID 7490683. doi:10.1002/path.1711770210.
- Loeb KR، Haas AL (1994). "Conjugates of ubiquitin cross-reactive protein distribute in a cytoskeletal pattern". Mol. Cell. Biol. 14 (12): 8408–19. PMC 359380. PMID 7526157.
- Narasimhan J، Potter JL، Haas AL (1996). "Conjugation of the 15-kDa interferon-induced ubiquitin homolog is distinct from that of ubiquitin". J. Biol. Chem. 271 (1): 324–30. PMID 8550581. doi:10.1074/jbc.271.1.324.
- D'Cunha J، Ramanujam S، Wagner RJ، وآخرون. (1996). "In vitro and in vivo secretion of human ISG15, an IFN-induced immunomodulatory cytokine". J. Immunol. 157 (9): 4100–8. PMID 8892645.
- Smith JK، Siddiqui AA، Krishnaswamy GA، وآخرون. (1999). "Oral use of interferon-alpha stimulates ISG-15 transcription and production by human buccal epithelial cells". J. Interferon Cytokine Res. 19 (8): 923–8. PMID 10476939. doi:10.1089/107999099313460.
- Bebington C، Doherty FJ، Fleming SD (1999). "Ubiquitin cross-reactive protein gene expression is increased in decidualized endometrial stromal cells at the initiation of pregnancy". Mol. Hum. Reprod. 5 (10): 966–72. PMID 10508226. doi:10.1093/molehr/5.10.966.
- Nyman TA، Matikainen S، Sareneva T، وآخرون. (2000). "Proteome analysis reveals ubiquitin-conjugating enzymes to be a new family of interferon-alpha-regulated genes". Eur. J. Biochem. 267 (13): 4011–9. PMID 10866800. doi:10.1046/j.1432-1327.2000.01433.x.
- Yuan W، Krug RM (2001). "Influenza B virus NS1 protein inhibits conjugation of the interferon (IFN)-induced ubiquitin-like ISG15 protein". EMBO J. 20 (3): 362–71. PMC 133459. PMID 11157743. doi:10.1093/emboj/20.3.362.
- Malakhov MP، Malakhova OA، Kim KI، وآخرون. (2002). "UBP43 (USP18) specifically removes ISG15 from conjugated proteins". J. Biol. Chem. 277 (12): 9976–81. PMID 11788588. doi:10.1074/jbc.M109078200.
- Meraro D، Gleit-Kielmanowicz M، Hauser H، Levi BZ (2002). "IFN-stimulated gene 15 is synergistically activated through interactions between the myelocyte/lymphocyte-specific transcription factors, PU.1, IFN regulatory factor-8/IFN consensus sequence binding protein, and IFN regulatory factor-4: characterization of a new subtype of IFN-stimulated response element". J. Immunol. 168 (12): 6224–31. PMID 12055236. doi:10.4049/jimmunol.168.12.6224.
- Padovan E، Terracciano L، Certa U، وآخرون. (2002). "Interferon stimulated gene 15 constitutively produced by melanoma cells induces e-cadherin expression on human dendritic cells". Cancer Res. 62 (12): 3453–8. PMID 12067988.
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