POLR2H

POLR2H
التراكيب المتوفرة بنك بيانات البروتين Ortholog search: PDBe RCSB قائمة رموز معرفات بنك بيانات البروتين 2F3I, 5FLM, 5IY9, 5IYA, 5IYC, 5IYB, 5IY7, 5IY8, 5IYD, 5IY6
المعرفات
الأسماء المستعارة	POLR2H, RPABC3, RPB17, RPB8, polymerase (RNA) II subunit H, RNA polymerase II subunit H, RNA polymerase II, I and III subunit H
معرفات خارجية	الوراثة المندلية البشرية عبر الإنترنت 606023 MGI: MGI:2384309 HomoloGene: 4540 GeneCards: 5437
علم الوجود الجيني الوظيفة الجزيئية • DNA-directed 5'-3' RNA polymerase activity • ربط دي إن إي • RNA polymerase I activity • RNA polymerase II activity • RNA polymerase III activity • single-stranded DNA binding المكونات الخلوية • نوية • بوليميراز الرنا II • بلازم نووي • عصارة خلوية • نواة • DNA-directed RNA polymerase III complex • DNA-directed RNA polymerase I complex • protein-DNA complex العمليات الحيوية • 7-methylguanosine mRNA capping • transcription elongation from RNA polymerase II promoter • transcription initiation from RNA polymerase I promoter • mRNA splicing, via spliceosome • positive regulation of gene expression, epigenetic • transcription-coupled nucleotide-excision repair • termination of RNA polymerase I transcription • transcription initiation from RNA polymerase II promoter • transcription from RNA polymerase II promoter • snRNA transcription from RNA polymerase II promoter • fibroblast growth factor receptor signaling pathway • transcription from RNA polymerase III promoter • RNA metabolic process • regulation of gene silencing by miRNA • نسخ الدنا • transcription elongation from RNA polymerase I promoter • positive regulation of type I interferon production • somatic stem cell population maintenance • positive regulation of viral transcription المصادر:Amigo / QuickGO
نمط التعبير عن الحمض النووي الريبوزي
المزيد من بيانات التعبير المرجعية
أورثولوج
الأنواع	الإنسان	الفأر
أنتريه	5437	245841
Ensembl	ENSG00000163882	ENSMUSG00000021018
يونيبروت	P52434	Q923G2
RefSeq (مرسال ر.ن.ا.)	‏NM_001278699، ‏NM_001278700، ‏NM_001278714، ‏NM_001278715، ‏NM_006232، ‏XM_006713666، ‏XM_006713667، ‏XM_017006636، ‏XM_017006637، ‏NM_001346879، ‏XM_024453602 NM_001278698، ‏NM_001278699، ‏NM_001278700، ‏NM_001278714، ‏NM_001278715، ‏NM_006232، ‏XM_006713666، ‏XM_006713667، ‏XM_017006636، ‏XM_017006637، ‏NM_001346879، ‏XM_024453602	‏NM_001356423، ‏XM_030249115 NM_145632، ‏NM_001356423، ‏XM_030249115
RefSeq (بروتين)	‏NP_001265628، ‏NP_001265629، ‏NP_001265643، ‏NP_001265644، ‏NP_001333808، ‏NP_006223، ‏XP_006713729، ‏XP_006713730، ‏XP_016862125، ‏XP_016862126، ‏XP_024309370 NP_001265627، ‏NP_001265628، ‏NP_001265629، ‏NP_001265643، ‏NP_001265644، ‏NP_001333808، ‏NP_006223، ‏XP_006713729، ‏XP_006713730، ‏XP_016862125، ‏XP_016862126، ‏XP_024309370	‏XP_006522200، ‏NP_001343352 NP_663607، ‏XP_006522200، ‏NP_001343352
الموقع (UCSC	n/a	Chr 16: 20.72 – 20.72 Mb
بحث ببمد	[1]	[2]
ويكي بيانات
اعرض/عدّل إنسان اعرض/عدّل فأر

POLR2H‏ (RNA polymerase II subunit H) هوَ بروتين يُشَفر بواسطة جين POLR2H في الإنسان.

الوظيفة

هذا القسم فارغ أو غير مكتمل، ساهم بتحريره.

الأهمية السريرية

هذا القسم فارغ أو غير مكتمل، ساهم بتحريره.

قراءة متعمقة

• Jeang KT (1998). "Tat, Tat-associated kinase, and transcription". J. Biomed. Sci. 5 (1): 24–7. doi:10.1007/BF02253352. PMID 9570510.
• Yankulov K, Bentley D (1998). "Transcriptional control: Tat cofactors and transcriptional elongation". Curr. Biol. 8 (13): R447–9. doi:10.1016/S0960-9822(98)70289-1. PMID 9651670.
• Romano G, Kasten M, De Falco G, et al. (2000). "Regulatory functions of Cdk9 and of cyclin T1 in HIV tat transactivation pathway gene expression". J. Cell. Biochem. 75 (3): 357–68. doi:10.1002/(SICI)1097-4644(19991201)75:3<357::AID-JCB1>3.0.CO;2-K. PMID 10536359.
• Marcello A, Zoppé M, Giacca M (2002). "Multiple modes of transcriptional regulation by the HIV-1 Tat transactivator". IUBMB Life. 51 (3): 175–81. doi:10.1080/152165401753544241. PMID 11547919.
• Stevens M, De Clercq E, Balzarini J (2007). "The regulation of HIV-1 transcription: molecular targets for chemotherapeutic intervention". Med Res Rev. 26 (5): 595–625. doi:10.1002/med.20081. PMID 16838299.
• Harrich D, McMillan N, Munoz L, et al. (2007). "Will diverse Tat interactions lead to novel antiretroviral drug targets?". Current drug targets. 7 (12): 1595–606. doi:10.2174/138945006779025338. PMID 17168834.
• Jang KL, Collins MK, Latchman DS (1992). "The human immunodeficiency virus tat protein increases the transcription of human Alu repeated sequences by increasing the activity of the cellular transcription factor TFIIIC". J. Acquir. Immune Defic. Syndr. 5 (11): 1142–7. PMID 1403646.
• Kato H, Sumimoto H, Pognonec P, et al. (1992). "HIV-1 Tat acts as a processivity factor in vitro in conjunction with cellular elongation factors". Genes Dev. 6 (4): 655–66. doi:10.1101/gad.6.4.655. PMID 1559613.
• Southgate C, Zapp ML, Green MR (1990). "Activation of transcription by HIV-1 Tat protein tethered to nascent RNA through another protein". Nature. 345 (6276): 640–2. Bibcode:1990Natur.345..640S. doi:10.1038/345640a0. PMID 2190099.
• Freund E, McGuire PM (1986). "Characterization of RNA polymerase type II from human term placenta". J. Cell. Physiol. 127 (3): 432–8. doi:10.1002/jcp.1041270312. PMID 3754875.
• Wu-Baer F, Sigman D, Gaynor RB (1995). "Specific binding of RNA polymerase II to the human immunodeficiency virus trans-activating region RNA is regulated by cellular cofactors and Tat". Proc. Natl. Acad. Sci. U.S.A. 92 (16): 7153–7. Bibcode:1995PNAS...92.7153W. doi:10.1073/pnas.92.16.7153. PMC 41297. PMID 7638159.
• Shpakovski GV, Acker J, Wintzerith M, et al. (1995). "Four subunits that are shared by the three classes of RNA polymerase are functionally interchangeable between Homo sapiens and Saccharomyces cerevisiae". Mol. Cell. Biol. 15 (9): 4702–10. PMC 230713. PMID 7651387.
• Herrmann CH, Rice AP (1995). "Lentivirus Tat proteins specifically associate with a cellular protein kinase, TAK, that hyperphosphorylates the carboxyl-terminal domain of the large subunit of RNA polymerase II: candidate for a Tat cofactor". J. Virol. 69 (3): 1612–20. PMC 188757. PMID 7853496.
• McKune K, Moore PA, Hull MW, Woychik NA (1996). "Six human RNA polymerase subunits functionally substitute for their yeast counterparts". Mol. Cell. Biol. 15 (12): 6895–900. PMC 230944. PMID 8524256.
• Keen NJ, Gait MJ, Karn J (1996). "Human immunodeficiency virus type-1 Tat is an integral component of the activated transcription-elongation complex". Proc. Natl. Acad. Sci. U.S.A. 93 (6): 2505–10. Bibcode:1996PNAS...93.2505K. doi:10.1073/pnas.93.6.2505. PMC 39827. PMID 8637904.
• Yang X, Herrmann CH, Rice AP (1996). "The human immunodeficiency virus Tat proteins specifically associate with TAK in vivo and require the carboxyl-terminal domain of RNA polymerase II for function". J. Virol. 70 (7): 4576–84. PMC 190394. PMID 8676484.
• Agostini I, Navarro JM, Rey F, et al. (1996). "The human immunodeficiency virus type 1 Vpr transactivator: cooperation with promoter-bound activator domains and binding to TFIIB". J. Mol. Biol. 261 (5): 599–606. doi:10.1006/jmbi.1996.0485. PMID 8800208.
• Zhou Q, Sharp PA (1996). "Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat". Science. 274 (5287): 605–10. Bibcode:1996Sci...274..605Z. doi:10.1126/science.274.5287.605. PMID 8849451.
• Okamoto H, Sheline CT, Corden JL, et al. (1996). "Trans-activation by human immunodeficiency virus Tat protein requires the C-terminal domain of RNA polymerase II". Proc. Natl. Acad. Sci. U.S.A. 93 (21): 11575–9. Bibcode:1996PNAS...9311575O. doi:10.1073/pnas.93.21.11575. PMC 38099. PMID 8876177.
• Chun RF, Jeang KT (1996). "Requirements for RNA polymerase II carboxyl-terminal domain for activated transcription of human retroviruses human T-cell lymphotropic virus I and HIV-1". J. Biol. Chem. 271 (44): 27888–94. doi:10.1074/jbc.271.44.27888. PMID 8910388.

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