EBF1
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هذا القسم فارغ أو غير مكتمل، ساهم بتحريره.
هذا القسم فارغ أو غير مكتمل، ساهم بتحريره.
EBF1 (Early B cell factor 1) هوَ بروتين يُشَفر بواسطة جين EBF1 في الإنسان.[1][2][3][4][5][6]
الوظيفة[عدل]

الأهمية السريرية[عدل]

المراجع[عدل]
- ^ "Symbol Report: EBF1". HUGO Gene Nomenclature Committee. مؤرشف من الأصل في 3 يناير 2018.
- ^ Milatovich A، Qiu RG، Grosschedl R، Francke U (Jul 1994). "Gene for a tissue-specific transcriptional activator (EBF or Olf-1), expressed in early B lymphocytes, adipocytes, and olfactory neurons, is located on human chromosome 5, band q34, and proximal mouse chromosome 11". Mamm. Genome. 5 (4): 211–5. PMID 8012110. doi:10.1007/BF00360547.
- ^ Hagman، James؛ Ramírez، Julita؛ Lukin، Kara (2012-01-01). "B lymphocyte lineage specification, commitment and epigenetic control of transcription by early B cell factor 1". Current Topics in Microbiology and Immunology. 356: 17–38. ISSN 0070-217X. PMC 3925327
. PMID 21735360. doi:10.1007/82_2011_139.
- ^ Treiber، Thomas؛ Mandel، Elizabeth M.؛ Pott، Sebastian؛ Györy، Ildiko؛ Firner، Sonja؛ Liu، Edison T.؛ Grosschedl، Rudolf. "Early B Cell Factor 1 Regulates B Cell Gene Networks by Activation, Repression, and Transcription- Independent Poising of Chromatin". Immunity. 32 (5): 714–725. doi:10.1016/j.immuni.2010.04.013. مؤرشف من الأصل في 05 يونيو 2018.
- ^ "Entrez Gene: EBF1 early B-cell factor 1". مؤرشف من الأصل في 05 ديسمبر 2010.
- ^ Schwartz، Anton M.؛ Putlyaeva، Lidia V.؛ Covich، Milica؛ Klepikova، Anna V.؛ Akulich، Kseniya A.؛ Vorontsov، Ilya E.؛ Korneev، Kirill V.؛ Dmitriev، Sergey E.؛ Polanovsky، Oleg L. (2016-10-01). "Early B-cell factor 1 (EBF1) is critical for transcriptional control of SLAMF1 gene in human B cells". Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1859 (10): 1259–1268. doi:10.1016/j.bbagrm.2016.07.004. مؤرشف من الأصل في 07 ديسمبر 2019.
قراءة متعمقة[عدل]
- Liberg D، Sigvardsson M، Akerblad P (2002). "The EBF/Olf/Collier family of transcription factors: regulators of differentiation in cells originating from all three embryonal germ layers". Mol. Cell. Biol. 22 (24): 8389–97. PMC 139877
. PMID 12446759. doi:10.1128/MCB.22.24.8389-8397.2002.
- Hagman J، Gutch MJ، Lin H، Grosschedl R (1995). "EBF contains a novel zinc coordination motif and multiple dimerization and transcriptional activation domains". EMBO J. 14 (12): 2907–16. PMC 398409
. PMID 7796816.
- Wang MM، Reed RR (1993). "Molecular cloning of the olfactory neuronal transcription factor Olf-1 by genetic selection in yeast". Nature. 364 (6433): 121–6. PMID 8321284. doi:10.1038/364121a0.
- Hagman J، Belanger C، Travis A، Turck CW، Grosschedl R (1993). "Cloning and functional characterization of early B-cell factor, a regulator of lymphocyte-specific gene expression". Genes Dev. 7 (5): 760–73. PMID 8491377. doi:10.1101/gad.7.5.760.
- Travis A، Hagman J، Hwang L، Grosschedl R (1993). "Purification of early-B-cell factor and characterization of its DNA-binding specificity". Mol. Cell. Biol. 13 (6): 3392–400. PMC 359803
. PMID 8497258.
- Tsai RY، Reed RR (1997). "Cloning and functional characterization of Roaz, a zinc finger protein that interacts with O/E-1 to regulate gene expression: implications for olfactory neuronal development". J. Neurosci. 17 (11): 4159–69. PMID 9151733.
- Gisler R، Jacobsen SE، Sigvardsson M (2000). "Cloning of human early B-cell factor and identification of target genes suggest a conserved role in B-cell development in man and mouse". Blood. 96 (4): 1457–64. PMID 10942392.
- Gisler R، Sigvardsson M (2002). "The human V-preB promoter is a target for coordinated activation by early B cell factor and E47". J. Immunol. 168 (10): 5130–8. PMID 11994467. doi:10.4049/jimmunol.168.10.5130.
- Smith EM، Gisler R، Sigvardsson M (2002). "Cloning and characterization of a promoter flanking the early B cell factor (EBF) gene indicates roles for E-proteins and autoregulation in the control of EBF expression". J. Immunol. 169 (1): 261–70. PMID 12077253. doi:10.4049/jimmunol.169.1.261.
- Zhao F، McCarrick-Walmsley R، Akerblad P، Sigvardsson M، Kadesch T (2003). "Inhibition of p300/CBP by early B-cell factor". Mol. Cell. Biol. 23 (11): 3837–46. PMC 155219
. PMID 12748286. doi:10.1128/MCB.23.11.3837-3846.2003.
- Merluzzi S، Moretti M، Altamura S، Zwollo P، Sigvardsson M، Vitale G، Pucillo C (2004). "CD40 stimulation induces Pax5/BSAP and EBF activation through a APE/Ref-1-dependent redox mechanism". J. Biol. Chem. 279 (3): 1777–86. PMID 14594818. doi:10.1074/jbc.M305418200.
- Bond HM، Mesuraca M، Carbone E، Bonelli P، Agosti V، Amodio N، De Rosa G، Di Nicola M، Gianni AM، Moore MA، Hata A، Grieco M، Morrone G، Venuta S (2004). "Early hematopoietic zinc finger protein (EHZF), the human homolog to mouse Evi3, is highly expressed in primitive human hematopoietic cells". Blood. 103 (6): 2062–70. PMID 14630787. doi:10.1182/blood-2003-07-2388.
- Smith EM، Akerblad P، Kadesch T، Axelson H، Sigvardsson M (2005). "Inhibition of EBF function by active Notch signaling reveals a novel regulatory pathway in early B-cell development". Blood. 106 (6): 1995–2001. PMID 15920012. doi:10.1182/blood-2004-12-4744.
- Akerblad P، Månsson R، Lagergren A، Westerlund S، Basta B، Lind U، Thelin A، Gisler R، Liberg D، Nelander S، Bamberg K، Sigvardsson M (2005). "Gene expression analysis suggests that EBF-1 and PPARgamma2 induce adipogenesis of NIH-3T3 cells with similar efficiency and kinetics". Physiol. Genomics. 23 (2): 206–16. PMID 16106032. doi:10.1152/physiolgenomics.00015.2005.
- Martínez A، Mas A، de las Heras V، Arroyo R، Fernández-Arquero M، de la Concha EG، Urcelay E (2005). "Early B-cell Factor gene association with multiple sclerosis in the Spanish population". BMC Neurol. 5: 19. PMC 1291372
. PMID 16255771. doi:10.1186/1471-2377-5-19.
- Roessler S، Györy I، Imhof S، Spivakov M، Williams RR، Busslinger M، Fisher AG، Grosschedl R (2007). "Distinct promoters mediate the regulation of Ebf1 gene expression by interleukin-7 and Pax5". Mol. Cell. Biol. 27 (2): 579–94. PMC 1800812
. PMID 17101802. doi:10.1128/MCB.01192-06.
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