GZMA
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هذا القسم فارغ أو غير مكتمل، ساهم بتحريره.
هذا القسم فارغ أو غير مكتمل، ساهم بتحريره.
GZMA (Granzyme A) هوَ بروتين يُشَفر بواسطة جين GZMA في الإنسان.[1][2][3]
الوظيفة[عدل]
هذا القسم فارغ أو غير مكتمل، ساهم بتحريره.الأهمية السريرية[عدل]
هذا القسم فارغ أو غير مكتمل، ساهم بتحريره.المراجع[عدل]
- ^ Masson D، Zamai M، Tschopp J (Dec 1986). "Identification of granzyme A isolated from cytotoxic T-lymphocyte-granules as one of the proteases encoded by CTL-specific genes". FEBS Lett. 208 (1): 84–8. PMID 3533635. doi:10.1016/0014-5793(86)81537-X.
- ^ "Entrez Gene: GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)". مؤرشف من الأصل في 05 ديسمبر 2010.
- ^ Hameed A، Lowrey DM، Lichtenheld M، Podack ER (Nov 1988). "Characterization of three serine esterases isolated from human IL-2 activated killer cells". J Immunol. 141 (9): 3142–7. PMID 3262682.
قراءة متعمقة[عدل]
- Pasternack MS، Bleier KJ، McInerney TN (1991). "Granzyme A binding to target cell proteins. Granzyme A binds to and cleaves nucleolin in vitro". J. Biol. Chem. 266 (22): 14703–8. PMID 1860869.
- Poe M، Bennett CD، Biddison WE، et al. (1988). "Human cytotoxic lymphocyte tryptase. Its purification from granules and the characterization of inhibitor and substrate specificity". J. Biol. Chem. 263 (26): 13215–22. PMID 3047119.
- Murphy ME، Moult J، Bleackley RC، et al. (1989). "Comparative molecular model building of two serine proteinases from cytotoxic T lymphocytes". Proteins. 4 (3): 190–204. PMID 3237717. doi:10.1002/prot.340040306.
- Gershenfeld HK، Hershberger RJ، Shows TB، Weissman IL (1988). "Cloning and chromosomal assignment of a human cDNA encoding a T cell- and natural killer cell-specific trypsin-like serine protease". Proc. Natl. Acad. Sci. U.S.A. 85 (4): 1184–8. PMC 279731
. PMID 3257574. doi:10.1073/pnas.85.4.1184. - Krähenbühl O، Rey C، Jenne D، et al. (1988). "Characterization of granzymes A and B isolated from granules of cloned human cytotoxic T lymphocytes". J. Immunol. 141 (10): 3471–7. PMID 3263427.
- Baetz K، Isaaz S، Griffiths GM (1995). "Loss of cytotoxic T lymphocyte function in Chediak-Higashi syndrome arises from a secretory defect that prevents lytic granule exocytosis". J. Immunol. 154 (11): 6122–31. PMID 7751653.
- Inoue M، Hoshino T، Fukuma T، et al. (1994). "Close co-localization of CD4 and a serine esterase tryptase TL2 on the cell-surface of human monocytoid and CD4+ lymphoid cells". Biochem. Biophys. Res. Commun. 201 (3): 1390–5. PMID 7912927. doi:10.1006/bbrc.1994.1857.
- Fink TM، Lichter P، Wekerle H، et al. (1994). "The human granzyme A (HFSP, CTLA3) gene maps to 5q11-q12 and defines a new locus of the serine protease superfamily". Genomics. 18 (2): 401–3. PMID 8288245. doi:10.1006/geno.1993.1483.
- Beresford PJ، Kam CM، Powers JC، Lieberman J (1997). "Recombinant human granzyme A binds to two putative HLA-associated proteins and cleaves one of them". Proc. Natl. Acad. Sci. U.S.A. 94 (17): 9285–90. PMC 23158. PMID 9256474. doi:10.1073/pnas.94.17.9285.
- Spaeny-Dekking EH، Hanna WL، Wolbink AM، et al. (1998). "Extracellular granzymes A and B in humans: detection of native species during CTL responses in vitro and in vivo". J. Immunol. 160 (7): 3610–6. PMID 9531325.
- Zhang D، Beresford PJ، Greenberg AH، Lieberman J (2001). "Granzymes A and B directly cleave lamins and disrupt the nuclear lamina during granule-mediated cytolysis". Proc. Natl. Acad. Sci. U.S.A. 98 (10): 5746–51. PMC 33284. PMID 11331782. doi:10.1073/pnas.101329598.
- Beresford PJ، Zhang D، Oh DY، et al. (2001). "Granzyme A activates an endoplasmic reticulum-associated caspase-independent nuclease to induce single-stranded DNA nicks". J. Biol. Chem. 276 (46): 43285–93. PMID 11555662. doi:10.1074/jbc.M108137200.
- Fan Z، Beresford PJ، Zhang D، Lieberman J (2002). "HMG2 Interacts with the Nucleosome Assembly Protein SET and Is a Target of the Cytotoxic T-Lymphocyte Protease Granzyme A". Mol. Cell. Biol. 22 (8): 2810–20. PMC 133744. PMID 11909973. doi:10.1128/MCB.22.8.2810-2820.2002.
- Strausberg RL، Feingold EA، Grouse LH، et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241. PMID 12477932. doi:10.1073/pnas.242603899.
- Fan Z، Beresford PJ، Zhang D، et al. (2003). "Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A". Nat. Immunol. 4 (2): 145–53. PMID 12524539. doi:10.1038/ni885.
- Pinkoski MJ، Green DR (2003). "Granzyme A: the road less traveled". Nat. Immunol. 4 (2): 106–8. PMID 12555094. doi:10.1038/ni0203-106.
- Saito S، Iida A، Sekine A، et al. (2003). "Catalog of 680 variations among eight cytochrome p450 ( CYP) genes, nine esterase genes, and two other genes in the Japanese population". J. Hum. Genet. 48 (5): 249–70. PMID 12721789. doi:10.1007/s10038-003-0021-7.
- Bell JK، Goetz DH، Mahrus S، et al. (2003). "The oligomeric structure of human granzyme A is a determinant of its extended substrate specificity". Nat. Struct. Biol. 10 (7): 527–34. PMID 12819769. doi:10.1038/nsb944.
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