LRP6
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هذا القسم فارغ أو غير مكتمل، ساهم بتحريره.
هذا القسم فارغ أو غير مكتمل، ساهم بتحريره.
LRP6 (LDL receptor related protein 6) هوَ بروتين يُشَفر بواسطة جين LRP6 في الإنسان.[1][2]
الوظيفة[عدل]

الأهمية السريرية[عدل]

المراجع[عدل]
- ^ "Entrez Gene: LRP6 low density lipoprotein receptor-related protein 6".
- ^ Brown SD، Twells RC، Hey PJ، Cox RD، Levy ER، Soderman AR، Metzker ML، Caskey CT، Todd JA، Hess JF (1998). "Isolation and characterization of LRP6, a novel member of the low density lipoprotein receptor gene family". Biochem. Biophys. Res. Commun. 248 (3): 879–88. PMID 9704021. doi:10.1006/bbrc.1998.9061.
قراءة متعمقة[عدل]
- He X، Semenov M، Tamai K، Zeng X (2004). "LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: arrows point the way.". Development. 131 (8): 1663–77. PMID 15084453. doi:10.1242/dev.01117.
- Hillier LD، Lennon G، Becker M، وآخرون. (1997). "Generation and analysis of 280,000 human expressed sequence tags.". Genome Res. 6 (9): 807–28. PMID 8889549. doi:10.1101/gr.6.9.807.
- Baens M، Wlodarska I، Corveleyn A، وآخرون. (1999). "A physical, transcript, and deletion map of chromosome region 12p12.3 flanked by ETV6 and CDKN1B: hypermethylation of the LRP6 CpG island in two leukemia patients with hemizygous del(12p).". Genomics. 56 (1): 40–50. PMID 10036184. doi:10.1006/geno.1998.5685.
- Tamai K، Semenov M، Kato Y، وآخرون. (2000). "LDL-receptor-related proteins in Wnt signal transduction.". Nature. 407 (6803): 530–5. PMID 11029007. doi:10.1038/35035117.
- Mao B، Wu W، Li Y، وآخرون. (2001). "LDL-receptor-related protein 6 is a receptor for Dickkopf proteins.". Nature. 411 (6835): 321–5. PMID 11357136. doi:10.1038/35077108.
- Semënov MV، Tamai K، Brott BK، وآخرون. (2001). "Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6.". Curr. Biol. 11 (12): 951–61. PMID 11448771. doi:10.1016/S0960-9822(01)00290-1.
- Li L، Mao J، Sun L، وآخرون. (2002). "Second cysteine-rich domain of Dickkopf-2 activates canonical Wnt signaling pathway via LRP-6 independently of dishevelled.". J. Biol. Chem. 277 (8): 5977–81. PMID 11742004. doi:10.1074/jbc.M111131200.
- Strausberg RL، Feingold EA، Grouse LH، وآخرون. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241
. PMID 12477932. doi:10.1073/pnas.242603899.
- Caricasole A، Ferraro T، Iacovelli L، وآخرون. (2003). "Functional characterization of WNT7A signaling in PC12 cells: interaction with A FZD5 x LRP6 receptor complex and modulation by Dickkopf proteins.". J. Biol. Chem. 278 (39): 37024–31. PMID 12857724. doi:10.1074/jbc.M300191200.
- Liu G، Bafico A، Harris VK، Aaronson SA (2003). "A novel mechanism for Wnt activation of canonical signaling through the LRP6 receptor.". Mol. Cell. Biol. 23 (16): 5825–35. PMC 166321
. PMID 12897152. doi:10.1128/MCB.23.16.5825-5835.2003.
- Zilberberg A، Yaniv A، Gazit A (2004). "The low density lipoprotein receptor-1, LRP1, interacts with the human frizzled-1 (HFz1) and down-regulates the canonical Wnt signaling pathway.". J. Biol. Chem. 279 (17): 17535–42. PMID 14739301. doi:10.1074/jbc.M311292200.
- Wang X، Adhikari N، Li Q، Hall JL (2005). "LDL receptor-related protein LRP6 regulates proliferation and survival through the Wnt cascade in vascular smooth muscle cells.". Am. J. Physiol. Heart Circ. Physiol. 287 (6): H2376–83. PMID 15271658. doi:10.1152/ajpheart.01173.2003.
- Suzuki Y، Yamashita R، Shirota M، وآخرون. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711–8. PMC 515316
. PMID 15342556. doi:10.1101/gr.2435604.
- Gerhard DS، Wagner L، Feingold EA، وآخرون. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. PMC 528928
. PMID 15489334. doi:10.1101/gr.2596504.
- Li Y، Lu W، He X، وآخرون. (2005). "LRP6 expression promotes cancer cell proliferation and tumorigenesis by altering beta-catenin subcellular distribution.". Oncogene. 23 (56): 9129–35. PMID 15516984. doi:10.1038/sj.onc.1208123.
- Semënov M، Tamai K، He X (2005). "SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor.". J. Biol. Chem. 280 (29): 26770–5. PMID 15908424. doi:10.1074/jbc.M504308200.
- Li Y، Chen J، Lu W، وآخرون. (2006). "Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding.". J. Cell Sci. 118 (Pt 22): 5305–14. PMID 16263759. doi:10.1242/jcs.02651.
- Mi K، Dolan PJ، Johnson GV (2006). "The low density lipoprotein receptor-related protein 6 interacts with glycogen synthase kinase 3 and attenuates activity.". J. Biol. Chem. 281 (8): 4787–94. PMID 16365045. doi:10.1074/jbc.M508657200.
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